|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
|
|
Deletion
|
DE(argA-thyA)232
,
OCL44,45-11
(D)
,
OCL44,45-15 (AK1-9 / BK2-9)
(D)
,
OCL44,45-3
(D)
|
|
Related gene (W3110 PEC)
|
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Gene Search
|
Search MG1655 PEC by gene name:
recC
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Related strains
|
|
Strains Search
|
Search strains by gene name:
recC
Search strains by all related name:
recC b2822 ECK2818 JW2790
|
General information (Go to Linear View: )
|
|
Gene Name
|
recC
|
|
Alternative name
|
b2822,ECK2818,JW2790
|
|
Location, Length
|
2,957,082 - 2,960,450
(
-
)
;
63.73
min
;
3369
(bp) ,
1122
(aa)
|
|
Product
|
exonuclease V (RecBCD complex), gamma chain
|
|
Operon Name
|
ppdAB-ygdB-ppdC-recC
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Note
|
DNA helicase, ATP-dependent dsDNA/ssDNA exonuclease V subunit, ssDNA endonuclease; GO_process: GO:0006308 - DNA catabolic process; GO_process: GO:0006310 - DNA recombination
|
|
Function
|
enzyme; Degradation of DNA
|
|
Gene Ontology
|
GO:0000166
;
nucleotide binding ( recC )
GO:0004386
;
helicase activity ( recC )
GO:0004518
;
nuclease activity ( recC )
GO:0004519
;
endonuclease activity ( recC )
GO:0004527
;
exonuclease activity ( recC )
GO:0005515
;
protein binding ( recC )
GO:0005524
;
ATP binding ( recC )
GO:0006281
;
DNA repair ( recC )
GO:0006974
;
response to DNA damage stimulus ( recC )
GO:0008854
;
exodeoxyribonuclease V activity ( recC )
GO:0009338
;
exodeoxyribonuclease V complex ( recC )
GO:0016787
;
hydrolase activity ( recC )
|
|
PID
|
1789186
|
EC number
(KEGG Pathway)
|
3.1.11.5
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
recC
(
EG10825
)
|
|
Number of removed
|
0 aa cleaved
|
|
SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
EX5C_ECOLI
(
P07648
)
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|
- Protein name
|
Exodeoxyribonuclease V gamma chain
|
|
- Synonyms
|
EC 3.1.11.5, Exodeoxyribonuclease V 125 kDa polypeptide
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|
- Gene name
|
Name=recC; OrderedLocusNames=b2822;
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Homology Analysis
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|
BLAST
|
|
Bacteria
|
|
GTOP
|
recC
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain C, Recbcd:dna Complex
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Exodeoxyribonuclease V gamma chain
|
|
PSI-BLAST
|
Exodeoxyribonuclease V gamma chain
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
exonuclease V (RecBCD complex), gamma chain [Escherichia coli K12]
|
|
Pfam 28.0
(database updated :
2015-05
)
|
|
Pfam
|
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PROSITE
|
|
PROSITE
|
ASN_GLYCOSYLATION
CAMP_PHOSPHO_SITE
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
TYR_PHOSPHO_SITE
MYRISTYL
RGD
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MMBR References
|
J Bacteriol. 1984;157(1):21-7.
Physical and biochemical analysis of the cloned recB and recC genes of Escherichia coli K-12.
Dykstra CC, Prasher D, Kushner SR.
(
6317651
)
|
Nucleic Acids Res. 1986;14:4437-4451
Complete nucleotide sequence of the Escherichia coli recC gene and of the thyA-recC intergenic region.
Finch, P. W., R. E. Wilson, K. Brown, I. D. Hickson, A. E. Tomlinson, and P. T. Emmerson.
|
J Bacteriol. 1983;156(3):1171-7.
Regulation of enterobactin iron transport in Escherichia coli: characterization of ent::Mu d(Apr lac) operon fusions.
Fleming TP, Nahlik MS, McIntosh MA.
(
6227609
)
|
Nature. 1981;294(5841):578-80.
Identification of the Escherichia coli recB and recC gene products.
Hickson ID, Emmerson PT.
(
6458768
)
|
Biochem Biophys Res Commun. 1982;109(2):414-22.
Fine structure of the recB and recC gene region of Escherichia coli.
Sasaki M, Fujiyoshi T, Shimada K, Takagi Y.
(
6295393
)
|
J Biol Chem. 1995;270:24451-24458
Monomeric RecBCD enzyme binds and unwinds DNA.
Taylor, A. F., and G. R. Smith.
|
J Biol Chem. 1971;246:6543-6555
The isolation and characterization of an adenosine triphosphate-dependent deoxyribonuclease directed by recB, C genes.
Wright, M., G. Bultin, and J. Hurwitz.
|
Mol Gen Genet. 1985;201(3):525-8.
Role of Escherichia coli RecBC enzyme in SOS induction.
Chaudhury AM, Smith GR.
(
3911029
)
|
Biochimie. 1991;73(4):523-32.
rec genes and homologous recombination proteins in Escherichia coli.
Clark AJ.
(
1911953
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MLRVYHSNRL DVLEALMEFI VERERLDDPF EPEMILVQST GMAQWLQMTL SQKFGIAANI DFPLPASFIW
0071 DMFVRVLPEI PKESAFNKQS MSWKLMTLLP QLLEREDFTL LRHYLTDDSD KRKLFQLSSK AADLFDQYLV
0141 YRPDWLAQWE TGHLVEGLGE AQAWQAPLWK ALVEYTHQLG QPRWHRANLY QRFIETLESA TTCPPGLPSR
0211 VFICGISALP PVYLQALQAL GKHIEIHLLF TNPCRYYWGD IKDPAYLAKL LTRQRRHSFE DRELPLFRDS
0281 ENAGQLFNSD GEQDVGNPLL ASWGKLGRDY IYLLSDLESS QELDAFVDVT PDNLLHNIQS DILELENRAV
0351 AGVNIEEFSR SDNKRPLDPL DSSITFHVCH SPQREVEVLH DRLLAMLEED PTLTPRDIIV MVADIDSYSP
0421 FIQAVFGSAP ADRYLPYAIS DRRARQSHPV LEAFISLLSL PDSRFVSEDV LALLDVPVLA ARFDITEEGL
0491 RYLRQWVNES GIRWGIDDDN VRELELPATG QHTWRFGLTR MLLGYAMESA QGEWQSVLPY DESSGLIAEL
0561 VGHLASLLMQ LNIWRRGLAQ ERPLEEWLPV CRDMLNAFFL PDAETEAAMT LIEQQWQAII AEGLGAQYGD
0631 AVPLSLLRDE LAQRLDQERI SQRFLAGPVN ICTLMPMRSI PFKVVCLLGM NDGVYPRQLA PLGFDLMSQK
0701 PKRGDRSRRD DDRYLFLEAL ISAQQKLYIS YIGRSIQDNS ERFPSVLVQE LIDYIGQSHY LPGDEALNCD
0771 ESEARVKAHL TCLHTRMPFD PQNYQPGERQ SYAREWLPAA SQAGKAHSEF VQPLPFTLPE TVPLETLQRF
0841 WAHPVRAFFQ MRLQVNFRTE DSEIPDTEPF ILEGLSRYQI NQQLLNALVE QDDAERLFRR FRAAGDLPYG
0911 AFGEIFWETQ CQEMQQLADR VIACRQPGQS MEIDLACNGV QITGWLPQVQ PDGLLRWRPS LLSVAQGMQL
0981 WLEHLVYCAS GGNGESRLFL RKDGEWRFPP LAAEQALHYL SQLIEGYREG MSAPLLVLPE SGGAWLKTCY
1051 DAQNDAMLDD DSTLQKARTK FLQAYEGNMM VRGEGDDIWY QRLWRQLTPE TMEAIVEQSQ RFLLPLFRFN
1121 QS
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 gggatgtgtc agcatcagcg ttacgctagt
-070 ttcacccggg ggcagagaag gcgagatgac ccgcctgcat tgcccgaatc gtcagtagtc aggagccgct
0001 atgttaaggg tctaccattc caatcgtctg gacgtgctgg aagcgttgat ggagtttatt gtcgaacgcg
0071 aacggctgga cgatcctttc gaaccagaga tgattctggt gcaaagtacc ggtatggcac agtggctgca
0141 aatgaccctg tcgcaaaagt ttggtattgc ggcaaacatt gattttccgc tgccagcgag ctttatctgg
0211 gatatgttcg tccgggtgtt accggaaatc cccaaagaga gcgcctttaa caaacagagc atgagctgga
0281 aactgatgac tctgctgccg caattgctgg agcgcgaaga ctttaccctg ttgcggcatt atctgactga
0351 cgatagcgac aagcgaaaac tgttccagct ttcctcaaaa gcggcggacc tgtttgacca gtatctggtc
0421 tatcgtccgg actggctggc acagtgggaa acaggacatt tggttgaagg gctgggagaa gcacaggcct
0491 ggcaagcccc gttgtggaag gcgctggtgg aatataccca tcaactcggg caaccgcgct ggcaccgcgc
0561 caatctctat cagcgcttta tcgaaacgct ggagtccgcg acgacctgcc cgccggggtt accttcgcgc
0631 gtctttatat gcggtatttc cgcgttaccg cctgtttatc tccaggcgct acaggcgctg ggtaaacata
0701 ttgaaatcca tctcctgttt accaacccct gccgttatta ctggggcgat attaaagatc ctgcttatct
0771 ggcgaaactg ctgacccgtc agcgtcgaca cagttttgaa gatcgcgaat tgccgctatt tcgtgatagc
0841 gaaaatgccg ggcagctctt taacagcgat ggtgaacagg atgtcggcaa cccgctgctg gcttcatggg
0911 gtaagcttgg gcgcgactac atttatctcc tttctgacct ggagagcagc caggagctgg acgcctttgt
0981 cgatgtcacg ccagataacc tgctgcataa cattcagtct gacattctgg aactggaaaa ccgcgccgtt
1051 gctggtgtga acatcgaaga gttttcccgt agcgataaca aacgcccgct tgatccactg gatagcagta
1121 tcaccttcca cgtttgccat agcccgcagc gtgaagttga agttttacac gatcgcctgc tggcgatgct
1191 ggaggaagac ccgacactta ctccgcgcga catcatcgtg atggtggctg atatcgacag ctacagtccg
1261 tttattcagg ctgtgtttgg tagcgcacct gcggatcgtt acctacctta cgccatttcc gaccgtcgtg
1331 cgcggcagtc acatccggta ctggaagcgt ttatcagcct gttatcactg cctgacagtc gttttgtgtc
1401 agaggatgtg ctggcgttgc tggatgtgcc ggtgctggcg gcgcggtttg acatcaccga agaagggctg
1471 cgttatttac gccagtgggt caacgaatcc ggcattcgtt ggggcataga tgacgacaac gttcgcgagc
1541 tggaactccc cgccaccgga caacacacct ggcgatttgg cctgacgcgt atgttgttgg gctacgcgat
1611 ggagagcgcg cagggcgagt ggcaatcggt tctaccttat gatgaatcga gcggcttaat tgcagaactg
1681 gtggggcatc tggcttcact gctaatgcag ctaaacatct ggcgtcgcgg gctggcacag gagcgtccgc
1751 tggaagagtg gttgccggtt tgtcgcgata tgctcaacgc cttcttcctg ccggatgcgg aaaccgaagc
1821 ggcgatgacg ctgatcgaac aacaatggca ggcgattatc gccgaaggtt taggtgcgca gtatggcgac
1891 gcggtgccgc tgtcactatt gcgtgatgaa ctggcacagc gtctggatca agaacgtatc agccagcgtt
1961 ttctcgccgg accggttaac atttgtactc tgatgccaat gcgttcaatt ccgttcaaag tggtttgcct
2031 gctgggaatg aacgacggcg tttatccacg tcagcttgcg ccattgggct ttgacctgat gagccagaaa
2101 ccgaagcgtg gcgaccgtag ccgtcgcgat gacgaccgct atctgttcct ggaagcgtta atttccgcgc
2171 agcaaaaact ctatatcagc tatatcggtc gttccattca ggataacagt gagcgtttcc cgtcggtact
2241 ggtgcaggaa ctgatcgact acatcgggca aagtcattat ctaccgggcg atgaagcgct caactgtgat
2311 gaaagcgagg caagggtaaa agcgcatctt acttgcctcc atacccggat gccgtttgat ccacaaaact
2381 accagccagg cgaacgacaa agctatgctc gtgaatggct acctgcggcc agccaggctg gtaaagcaca
2451 ttctgaattt gttcagccgc tgccgtttac cttaccggaa accgtgccgc tggaaacgct acaacgattc
2521 tgggcacatc cggtgcgggc atttttccag atgcgtttgc aggtgaactt ccgtactgaa gacagcgaaa
2591 tccccgacac cgagccattt attctggaag gacttagccg ttatcaaatc aatcagcagt tattgaatgc
2661 actggttgag caggatgatg ccgaacgctt gttccgccgc ttccgagcgg caggggattt accgtatggc
2731 gcttttggtg aaattttctg ggaaacacag tgccaggaga tgcagcagct tgccgacaga gtcattgcct
2801 gtcgccagcc ggggcagagt atggaaattg atctcgcctg caacggtgtg cagataactg gctggttgcc
2871 gcaggtgcag ccggatggcc tgttgcgctg gcgtccctct ttattaagtg tggcccaggg aatgcaactt
2941 tggctggaac accttgtcta ctgtgccagc ggtggtaatg gtgaaagtcg cctttttcta cgcaaagacg
3011 gcgagtggcg ttttccgccg cttgcagccg aacaggcttt gcattacctc tcacaactga ttgaggggta
3081 tcgtgaagga atgtccgcgc cattgctggt gttacctgaa agtggcggcg cgtggctaaa aacctgttat
3151 gacgcgcaaa acgatgccat gctggatgac gattccacgt tgcaaaaagc ccgtacgaaa ttccttcagg
3221 cttacgaagg caacatgatg gtgcgtggcg aaggtgatga tatctggtat caaaggctct ggcggcaatt
3291 aacaccagag acaatggagg ccatcgttga acagtcgcaa cgtttcctgt taccgctgtt tcgctttaat
3361 cagtcatgag tgctgtataa aaattgcgca atctatccgc ttactttatg atgcgcacca gtcacggact
3431 gatggttata taaacatagg ctgactcgtg cagcacaag
|
