MG1655
W3110
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Gene Report : sdaB
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)  
     Deletion LD3-18-1 (LD)  ,  DE(relA-argA)216  ,  OCL44,45-1 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  sdaB
Related strains
     Strains Search Search strains by gene name:  sdaB   Search strains by all related name:  sdaB b2797 ECK2792 JW2768

General information  (Go to Linear View:)
 Gene Name sdaB  
 Alternative name b2797,ECK2792,JW2768  
 Location, Length 2,927,598 - 2,928,965 (  +  ) ;   63.10 min ; 1368 (bp) ,   455 (aa) Go to Linear View
 Product L-serine deaminase II  
 Operon Name sdaCB  
 Note L-serine dehydratase (deaminase), L-SD2; GO_process: GO:0019395 - fatty acid oxidation; GO_process: GO:0009063 - cellular amino acid catabolic process  
 Function enzyme; Degradation of small molecules: Amino acids  
 Gene Ontology GO:0003941; L-serine ammonia-lyase activity ( sdaB )
GO:0005506; iron ion binding ( sdaB )
GO:0005515; protein binding ( sdaB )
GO:0006094; gluconeogenesis ( sdaB )
GO:0016829; lyase activity ( sdaB )
GO:0046872; metal ion binding ( sdaB )
GO:0051536; iron-sulfur cluster binding ( sdaB )
GO:0051539; 4 iron, 4 sulfur cluster binding ( sdaB )
 PID 1789161  
 EC number
  (KEGG Pathway)
 
4.3.1.17  
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) SDHM_ECOLI ( P30744 ; Q59377 )
    -  Protein name L-serine dehydratase 2  
    -  Synonyms EC 4.3.1.17, L-serine deaminase 2, SDH 2, L-SD2  
    -  Gene name Name=sdaB; OrderedLocusNames=b2797;  

 Linear View (Whole Mode)
View Location
   2915.0  –  2940.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP sdaB (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, The Crystal Structure Of Iron, Sulfur-Dependent L-Serine Dehydratase From Legionella Pneumophila Subsp. Pneumophila  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST L-serine dehydratase 2  
         PSI-BLAST L-serine dehydratase 1
    nr     (database updated : 2007.02.20 )
         BLAST L-serine deaminase II [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    CAMP_PHOSPHO_SITE    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    TYR_PHOSPHO_SITE    MYRISTYL    PROKAR_LIPOPROTEIN     

Other Cross-Reference
    COG COG1760E 
    EcoCyc sdaB 

MMBR References
Eur J Biochem. 1994;222:901-907
Sequencing and characterization of the sdaC gene and identification of the sdaCB operon in Escherichia coli K12.
Shao, Z., R. T. Lin, and E. B. Newman.
J Bacteriol. 1991;173(8):2473-80.
A novel L-serine deaminase activity in Escherichia coli K-12.
Su H, Newman EB. ( 2013569 )

Sequences
Amino acid
FASTA format
0001 MISVFDIFKI GIGPSSSHTV GPMKAGKQFT DDLIARNLLK DVTRVVVDVY GSLSLTGKGH HTDIAIIMGL 
0071 AGNLPDTVDI DSIPSFIQDV NTHGRLMLAN GQHEVEFPVD QCMNFHADNL SLHENGMRIT ALAGDKVVYS 
0141 QTYYSIGGGF IVDEEHFGQQ DSAPVEVPYP YSSAADLQKH CQETGLSLSG LMMKNELALH SKEELEQHLA 
0211 NVWEVMRGGI ERGISTEGVL PGKLRVPRRA AALRRMLVSQ DKTTTDPMAV VDWINMFALA VNEENAAGGR 
0281 VVTAPTNGAC GIIPAVLAYY DKFIREVNAN SLARYLLVAS AIGSLYKMNA SISGAEVGCQ GEVGVACSMA 
0351 AAGLAELLGA SPAQVCIAAE IAMEHNLGLT CDPVAGQVQV PCIERNAIAA VKAVNAARMA LRRTSEPRVC 
0421 LDKVIETMYE TGKDMNAKYR ETSRGGLAMK IVACD

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             TCTGATTGCA ATCTCCGCAA TCTTCTACTC 
-070 TCTGTTCAGC TAAGTCCTTT CGCGCCGCTT TCGGGCGGCG CTTCCTCCGT TTTAACGCGA TGTATTTCCT 
0001 atgattagcg tattcgatat tttcaaaatc ggcattggcc cttccagttc tcataccgtt ggaccaatga 
0071 aagcgggtaa acaatttacc gacgatctga ttgcccgtaa cctgcttaaa gacgtgaccc gcgtggtggt 
0141 tgacgtgtac ggctcgctct ctctgaccgg taaaggccac cacactgata tcgccattat tatgggcctg 
0211 gcgggtaacc tgccggatac cgtggatatc gattccatcc ccagttttat tcaggatgtg aatactcatg 
0281 gtcgcctgat gctggcaaac ggtcagcatg aagtggagtt cccggttgat cagtgcatga acttccacgc 
0351 cgacaacctt tctctgcatg aaaacggtat gcgcattacc gcgctggcgg gcgataaagt cgtttacagc 
0421 cagacttact actctattgg cggtggcttt atcgttgatg aagagcattt tggccagcag gatagcgcac 
0491 cggttgaagt tccttatccg tacagttcag cagccgatct gcaaaaacat tgtcaggaaa ccgggctgtc 
0561 actctctggc ctgatgatga aaaacgagct ggcgctgcac agcaaagaag agctggaaca gcacctggcg 
0631 aacgtctggg aagtcatgcg cggcggtatt gagcgcggta tttccaccga aggcgtgttg cctggcaaac 
0701 tgcgcgttcc acgccgtgct gcggcactac gccggatgct ggtcagccag gataaaacca ccactgaccc 
0771 gatggcggtt gttgactgga tcaacatgtt tgcactggca gtgaacgaag agaacgctgc tggcggtcgc 
0841 gtggtgactg cgccgactaa cggtgcgtgc gggattatcc cggcagttct ggcgtactac gacaagttta 
0911 tccgcgaagt gaacgctaac tcactggctc gttacctgct ggtagccagc gccattggtt ctctttataa 
0981 gatgaacgcg tcgatttctg gtgctgaagt gggttgccag ggtgaagttg gcgtggcgtg ctcaatggcg 
1051 gcggctggtc tggcagaact attaggcgca agcccggcgc aggtgtgcat cgcggcggaa atcgccatgg 
1121 agcacaacct cggtctgacg tgtgacccgg tcgccggaca ggtacaggtg ccatgcatcg agcgtaacgc 
1191 cattgcggca gtaaaagcgg tgaacgccgc acgtatggcg ctgcgccgta ccagcgagcc gcgcgtctgc 
1261 ctcgataaag ttatcgaaac catgtacgaa acaggtaaag atatgaacgc caagtaccgc gaaacctctc 
1331 gcggcggcct ggcaatgaag atcgttgcct gcgattaaTC GCTCTCCAAA GGCCTCGTTT TGCGAGGCCT 
1401 CTTCCCGATT TCTCATCCAG CCGTAGCCTG TTCCGGCATC GAATGTTACC CTTATCGCCT GATCTTTA