MG1655
W3110
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Gene Report : barA
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)  
     Deletion LD3-18-1 (LD)  ,  DE(relA-argA)216  ,  OCL44,45-1 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  barA
Related strains
     Strains Search Search strains by gene name:  barA   Search strains by all related name:  barA airS b2786 ECK2780 gacC JW2757

General information  (Go to Linear View:)
 Gene Name barA  
 Alternative name airS,b2786,ECK2780,gacC,JW2757  
 Location, Length 2,913,079 - 2,915,835 (  +  ) ;   62.79 min ; 2757 (bp) ,   918 (aa) Go to Linear View
 Product hybrid sensory histidine kinase, in two-component regulatory system with UvrY  
 Operon Name barA  
 Note sensor-regulator, activates OmpR by phophorylation; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0006464 - protein modification process  
 Function enzyme; Global regulatory functions  
 Gene Ontology GO:0000155; two-component sensor activity ( barA )
GO:0000156; two-component response regulator activity ( barA )
GO:0000160; two-component signal transduction system (phosphorelay) ( barA )
GO:0004673; protein histidine kinase activity ( barA )
GO:0004871; signal transducer activity ( barA )
GO:0005524; ATP binding ( barA )
GO:0005886; plasma membrane ( barA )
GO:0006350; transcription ( barA )
GO:0006355; regulation of transcription, DNA-dependent ( barA )
GO:0007165; signal transduction ( barA )
GO:0016020; membrane ( barA )
GO:0016021; integral to membrane ( barA )
GO:0016301; kinase activity ( barA )
GO:0016310; phosphorylation ( barA )
GO:0016740; transferase activity ( barA )
GO:0016772; transferase activity, transferring phosphorus-containing groups ( barA )
GO:0018106; peptidyl-histidine phosphorylation ( barA )
 PID 1789149  
 EC number
  (KEGG Pathway)
 
 
SWISS-PROT  ( Show details )
  botton Entry name(Acc.no) BARA_ECOLI ( P26607 ; P77032 )
    -  Protein name Sensor protein barA  
    -  Synonyms EC 2.7.3.-  
    -  Gene name Name=barA; OrderedLocusNames=b2786, c3349, z4101, ECs3646;  

 Linear View (Whole Mode)
View Location
   2900.0  –  2925.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP barA (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Structure Of The Entire Cytoplasmic Portion Of A Sensor Histidine Kinase Protein  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Signal transduction histidine-protein kinase barA  
         PSI-BLAST Signal transduction histidine-protein kinase barA
    nr     (database updated : 2007.02.20 )
         BLAST sensor-regulator, activates OmpR by phophorylation [Escherichia coli O157:H7 EDL933]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    CAMP_PHOSPHO_SITE    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    AMIDATION     

Other Cross-Reference
    COG COG0642T 
    EcoCyc barA 

MMBR References
EMBO J. 1994;13:5195-5202
A novel device of bacterial signal transducers.
Ishige, K., S. Nagasawa, S. Tokishita, and T. Mizuno.
Mol Microbiol. 1992;6(6):799-807.
A novel sensor-regulator protein that belongs to the homologous family of signal-transduction proteins involved in adaptive responses in Escherichia coli.
Nagasawa S, Tokishita S, Aiba H, Mizuno T. ( 1574005 )

Sequences
Amino acid
FASTA format
0001 MTNYSLRARM MILILAPTVL IGLLLSIFFV VHRYNDLQRQ LEDAGASIIE PLAVSTEYGM SLQNRESIGQ 
0071 LISVLHRRHS DIVRAISVYD ENNRLFVTSN FHLDPSSMQL GSNVPFPRQL TVTRDGDIMI LRTPIISESY 
0141 SPDESPSSDA KNSQNMLGYI ALELDLKSVR LQQYKEIFIS SVMMLFCIGI ALIFGWRLMR DVTGPIRNMV 
0211 NTVDRIRRGQ LDSRVEGFML GELDMLKNGI NSMAMSLAAY HEEMQHNIDQ ATSDLRETLE QMEIQNVELD 
0281 LAKKRAQEAA RIKSEFLANM SHELRTPLNG VIGFTRLTLK TELTPTQRDH LNTIERSANN LLAIINDVLD 
0351 FSKLEAGKLI LESIPFPLRS TLDEVVTLLA HSSHDKGLEL TLNIKSDVPD NVIGDPLRLQ QIITNLVGNA 
0421 IKFTENGNID ILVEKRALSN TKVQIEVQIR DTGIGIPERD QSRLFQAFRQ ADASISRRHG GTGLGLVITQ 
0491 KLVNEMGGDI SFHSQPNRGS TFWFHINLDL NPNIIIEGPS TQCLAGKRLA YVEPNSAAAQ CTLDILSETP 
0561 LEVVYSPTFS ALPPAHYDMM LLGIAVTFRE PLTMQHERLA KAVSMTDFLM LALPCHAQVN AEKLKQDGIG 
0631 ACLLKPLTPT RLLPALTEFC HHKQNTLLPV TDESKLAMTV MAVDDNPANL KLIGALLEDM VQHVELCDSG 
0701 HQAVERAKQM PFDLILMDIQ MPDMDGIRAC ELIHQLPHQQ QTPVIAVTAH AMAGQKEKLL GAGMSDYLAK 
0771 PIEEERLHNL LLRYKPGSGI SSRVVTPEVN EIVVNPNATL DWQLALRQAA GKTDLARDML QMLLDFLPEV 
0841 RNKVEEQLVG ENPEGLVDLI HKLHGSCGYS GVPRMKNLCQ LIEQQLRSGT KEEDLEPELL ELLDEMDNVA 
0911 REASKILG

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             TGACGCGTCG TCGTGCGTCG TTTTGCAGAG 
-070 TAGAATTGCG CCATTGGCGA GACTTTCTCA ATTTAACAGT GTGACCTTAA TTGTCCCATA ACGGAACTCC 
0001 atgaccaact acagcctgcg cgcacgcatg atgattctga tcctggcacc gaccgtcctt attggtttat 
0071 tgctgagtat ctttttcgtc gtgcatcgct ataacgactt gcagcgtcaa ctggaagatg ccggtgccag 
0141 cattattgag ccgcttgcag tttctactga atatggcatg agcctgcaaa atcgcgaatc tatcggtcag 
0211 ttaataagcg tactgcatcg tcgccattcc gatattgttc gcgcgatttc ggtttatgat gaaaataacc 
0281 gactctttgt cacctccaat tttcatcttg atccctcatc aatgcagctc ggcagcaacg tgccgtttcc 
0351 tcgccagctc actgtcactc gtgacggcga tattatgatc ctccgcacgc cgattatttc tgagagttac 
0421 tcccccgacg aatcgcccag tagcgatgcc aaaaatagtc aaaatatgtt gggatatatt gcgctggagc 
0491 tggatcttaa atcggttcgc ttgcagcaat ataaagagat ctttatttcc agcgtgatga tgctgttttg 
0561 tatcggtatt gcgcttattt ttggctggcg cttaatgcgc gatgtaaccg gtccgattcg caacatggtg 
0631 aataccgtcg accgcatccg tcgcgggcaa ctcgacagcc gggtggaagg atttatgctc ggcgagctgg 
0701 atatgctgaa aaacggtatc aactcgatgg caatgtcgct ggctgcttat cacgaagaga tgcagcacaa 
0771 tatcgaccag gcgacgtccg atctgcgtga aacgctggag cagatggaaa ttcagaacgt tgagttagat 
0841 ctggcgaaaa agcgcgccca ggaagcggcg cgtattaaat ccgagtttct ggcaaatatg tcacacgagc 
0911 tgcgtacacc actgaatggt gttattggct ttacccgcct gacgctgaaa acagaattaa caccaacgca 
0981 gcgcgatcac ctgaatacga ttgaacgttc ggcaaataat ttgctggcaa ttattaatga tgttctcgac 
1051 ttctcgaaac tggaagcagg taagctgatt ctggaaagta ttccattccc actacgcagc acgctggatg 
1121 aagtcgttac tctgctggca cattcttctc acgataaagg gttagaactg acgctcaata ttaaaagcga 
1191 cgtgcctgat aacgtgatcg gcgacccgct gcgattacag caaatcatca ctaacctggt ggggaatgca 
1261 attaaattca ccgagaatgg caacattgat attctggtag aaaaacgtgc gctgagtaat accaaagtgc 
1331 agattgaagt gcagattcgg gataccggca ttggtattcc tgaacgcgat caatcgcgct tattccaggc 
1401 cttccgacag gctgatgcca gtatttcccg ccgtcatggt ggcaccgggc tggggctggt gattacacaa 
1471 aaactggtta atgaaatggg cggcgatatt tcgttccata gccagccgaa tcgcggttca actttctggt 
1541 tccacattaa tctcgatctg aacccgaaca ttattatcga agggccatcc acccagtgcc tcgcaggtaa 
1611 gcgcctggcc tatgtcgaac caaactccgc agcagcgcaa tgcacgctgg atattttaag tgaaacgccg 
1681 ctggaagtgg tttatagccc aacgttctcc gcgctgcctc ccgcgcatta cgacatgatg ttgttaggca 
1751 tcgcggtgac cttccgcgag ccgctaacaa tgcaacatga gcgattagcg aaagcggtat cgatgaccga 
1821 tttcctgatg ctggcacttc cttgccatgc acaagtcaat gctgaaaaac tcaagcaaga tggtatcggc 
1891 gcgtgtctgc tgaaaccatt aacacctaca cgcctgttgc ctgccctgac ggaattttgt catcacaaac 
1961 aaaacacgct tttgcctgta accgatgaaa gtaagctggc aatgacagtc atggcggttg atgacaaccc 
2031 cgctaacctg aaacttatcg gcgcattgct ggaagatatg gtgcaacatg tggaactttg cgatagcggg 
2101 catcaggcgg ttgaacgggc gaaacagatg ccgttcgatt tgatcttaat ggatattcaa atgccggaca 
2171 tggatggcat tcgggcctgc gaactcatcc accaactccc gcatcagcaa caaacgccgg ttatcgcggt 
2241 aacggcgcat gcaatggccg ggcaaaaaga gaagctgctt ggcgcaggga tgagcgatta tctggcgaaa 
2311 ccgattgaag aagagcgatt gcataatttg ttgttgcgct acaagcctgg cagcggtatt tcctctcgcg 
2381 tcgtgacgcc cgaagtcaac gaaattgtgg tgaacccgaa tgcgaccctc gactggcaac tggcactacg 
2451 ccaggcagca ggaaaaaccg atttagcgcg cgatatgctg caaatgttac tcgatttcct gcctgaagtt 
2521 cgcaacaaag ttgaggaaca gctggttgga gaaaacccgg aaggcctggt tgatttgatt cataaactgc 
2591 atggcagttg cggctatagc ggtgtgccac gtatgaagaa tctctgccaa ctgatcgaac aacagctacg 
2661 tagcggtact aaagaagaag atttggaacc ggagctgctg gaactgttgg acgagatgga taatgtcgcg 
2731 cgcgaagcca gcaaaattct cgggtaaTGG ATGTCTTGTC GAGTAGCAAT CGGCTTTTTA TGACGCTGGT 
2801 TTCAGATTGG TGACAAAGTG CCTGTGTTTA TGCCGGATGC GGCGTTAACG CCTTATC