MG1655
W3110
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Gene Report : mazE
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
     Deletion LD3-18-1 (LD)  ,  OCL45-4 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  mazE
Related strains
     Strains Search Search strains by gene name:  mazE   Search strains by all related name:  mazE b2783 chpAI chpR ECK2777 JW2754 mazE tasA

General information  (Go to Linear View:)
 Gene Name mazE  
 Alternative name b2783,chpAI,chpR,ECK2777,JW2754,mazE,tasA  
 Location, Length 2,909,113 - 2,909,361 (  -  ) ;   62.70 min ; 249 (bp) ,   82 (aa) Go to Linear View
 Product antitoxin of the ChpA-ChpR toxin-antitoxin system  
 Operon Name relA-chpRA-mazG  
 Note suppressor of inhibitory function of ChpA, PemI-like, autoregulated  
 Function phenotype; Not classified  
 Gene Ontology GO:0003677; DNA binding ( chpR )
 PID 1789146  
 EC number
  (KEGG Pathway)   		 
SWISS-PROT  ( Show details )
  botton Entry name(Acc.no) CHPR_ECOLI ( P18534 )
    -  Protein name PemI-like protein 1  
    -  Synonyms MazE protein  
    -  Gene name OrderedLocusNames=b2783, z4098, ECs3643;  

 Linear View (Whole Mode)
View Location
   2900.0  –  2925.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP chpR (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain C, Crystal Structure Of Mazef Complex  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST PemI-like protein 1 (Protein mazE)  
         PSI-BLAST PemI-like protein 1 (Protein mazE)
    nr     (database updated : 2007.02.20 )
         BLAST Chain C, Crystal Structure Of Mazef Complex  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL     

Other Cross-Reference
    COG COG2336T 
    EcoCyc mazE 

MMBR References
J Bacteriol. 1993;175:6850-6856
chpA and chpB, Escherichia coli chromosomal homologs of the pem locus responsible for stable maintenance of plasmid R100.
Masuda, Y., K. Miyakawa, Y. Nishimura, and E. Ohtsubo.
Proc Natl Acad Sci U S A. 1996;93:6059-6063
An Escherichia coli chromosomal "addiction module" regulated by 3',5'-bispyrophosphate: a model for programmed bacterial cell death.
Aizenman, E., H. Engelberg-Kulka, and G. Glaser.

Sequences
Amino acid
FASTA format 
0001 MIHSSVKRWG NSPAVRIPAT LMQALNLNID DEVKIDLVDG KLIIEPVRKE PVFTLAELVN DITPENLHEN 
0071 IDWGEPKDKE VW
Nucleotide
FASTA format

View sequence out neighbor 100bp 
-100                                             cgcgtcggtt gcacgggagt taggccgaaa 
-070 tttgctcgta tctacaatgt agattgatat atactgtatc tacatatgat agcggtttga ggaaagggtt 
0001 atgatccaca gtagcgtaaa gcgttgggga aattcaccgg cggtgcggat cccggctacg ttaatgcagg 
0071 cgctcaatct gaatattgat gatgaagtga agattgacct ggtggatggc aaattaatta ttgagccagt 
0141 gcgtaaagag cccgtattta cgcttgctga actggtcaac gacatcacgc cggaaaacct ccacgagaat 
0211 atcgactggg gagagccgaa agataaggaa gtctggtaat ggtaagccga tacgtacccg atatgggcga 
0281 tctgatttgg gttgattttg acccgacaaa aggtagcgag caagctggac atcgtccagc tgttgtcct