MG1655
W3110
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Gene Report : mazF
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
     Deletion LD3-18-1 (LD)  ,  OCL45-4 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  mazF
Related strains
     Strains Search Search strains by gene name:  mazF   Search strains by all related name:  mazF b2782 chpA chpAK ECK2776 JW2753 mazF

General information  (Go to Linear View:)
 Gene Name mazF  
 Alternative name b2782,chpA,chpAK,ECK2776,JW2753,mazF  
 Location, Length 2,908,778 - 2,909,113 (  -  ) ;   62.69 min ; 336 (bp) ,   111 (aa) Go to Linear View
 Product mRNA interferase toxin, antitoxin is MazE  
 Operon Name relA-chpRA-mazG  
 Note probable growth inhibitor, PemK-like, autoregulated  
 Function putative factor; Not classified  
 Gene Ontology GO:0003677; DNA binding ( chpA )
GO:0005515; protein binding ( chpA )
 PID 1789145  
 EC number
  (KEGG Pathway)
 
 
SWISS-PROT  ( Show details )
  botton Entry name(Acc.no) CHPA_ECOLI ( P33645 )
    -  Protein name PemK-like protein 1  
    -  Synonyms MazF protein  
    -  Gene name OrderedLocusNames=b2782, z4097, ECs3642;  

 Linear View (Whole Mode)
View Location
   2900.0  –  2925.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP chpA (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Crystal Structure Of Mazef Complex  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST PemK-like protein 1 (Protein mazF)  
         PSI-BLAST PemK-like protein 1 (Protein mazF)
    nr     (database updated : 2007.02.20 )
         BLAST probable growth inhibitor, PemK-like, autoregulated [Escherichia coli O157:H7 EDL933]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    CAMP_PHOSPHO_SITE    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL     

Other Cross-Reference
    COG COG2337T 
    EcoCyc mazF 

MMBR References
J Bacteriol. 1993;175:6850-6856
chpA and chpB, Escherichia coli chromosomal homologs of the pem locus responsible for stable maintenance of plasmid R100.
Masuda, Y., K. Miyakawa, Y. Nishimura, and E. Ohtsubo.
Proc Natl Acad Sci U S A. 1996;93:6059-6063
An Escherichia coli chromosomal "addiction module" regulated by 3',5'-bispyrophosphate: a model for programmed bacterial cell death.
Aizenman, E., H. Engelberg-Kulka, and G. Glaser.

Sequences
Amino acid
FASTA format
0001 MVSRYVPDMG DLIWVDFDPT KGSEQAGHRP AVVLSPFMYN NKTGMCLCVP CTTQSKGYPF EVVLSGQERD 
0071 GVALADQVKS IAWRARGATK KGTVAPEELQ LIKAKINVLI G

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             agcccgtatt tacgcttgct gaactggtca 
-070 acgacatcac gccggaaaac ctccacgaga atatcgactg gggagagccg aaagataagg aagtctggta 
0001 atggtaagcc gatacgtacc cgatatgggc gatctgattt gggttgattt tgacccgaca aaaggtagcg 
0071 agcaagctgg acatcgtcca gctgttgtcc tgagtccttt catgtacaac aacaaaacag gtatgtgtct 
0141 gtgtgttcct tgtacaacgc aatcaaaagg atatccgttc gaagttgttt tatccggtca ggaacgtgat 
0211 ggcgtagcgt tagctgatca ggtaaaaagt atcgcctggc gggcaagagg agcaacgaag aaaggaacag 
0281 ttgccccaga ggaattacaa ctcattaaag ccaaaattaa cgtactgatt gggtagtgtt actaactcac 
0351 ttctattctg gtcacaggtt tccacctgac agacccgcaa ttttcaggac aattcaatga atcaaatcga 
0421 ccgtttgctc actatt