MG1655
W3110
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Gene Report : srlD
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)  
     Deletion 21 (LD)  ,  DE(recA-srlR)300  ,  OCL47,48-1 (LD 21_CRS) (D)  ,  OCL47,48-2 (LD 21_P/O) (D)  ,  OCL48 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  srlD
Related strains
     Strains Search Search strains by gene name:  srlD   Search strains by all related name:  srlD b2705 ECK2700 gutD JW2674

General information  (Go to Linear View:)
 Gene Name srlD  
 Alternative name b2705,ECK2700,gutD,JW2674  
 Location, Length 2,825,759 - 2,826,538 (  +  ) ;   60.90 min ; 780 (bp) ,   259 (aa) Go to Linear View
 Product sorbitol-6-phosphate dehydrogenase  
 Operon Name srlAEBD-gutM-srlR-gutQ  
 Note glucitol (sorbitol)-6-phosphate dehydrogenase; GO_process: GO:0016052 - carbohydrate catabolic process  
 Function enzyme; Degradation of small molecules: Carbon compounds  
 Gene Ontology GO:0003824 ; catalytic activity ( srlD )
GO:0005488 ; binding ( srlD )
GO:0008152 ; metabolic process ( srlD )
GO:0009010 ; sorbitol-6-phosphate 2-dehydrogenase activity ( srlD )
GO:0016491 ; oxidoreductase activity ( srlD )
 PID 1789057  
 EC number
  (KEGG Pathway)
 
1.1.1.140  
Verified Protein Starts (data compiled from literature and appropriate citations are available from EcoGene)
     EcoGene srlD ( EG10971 )  
    Number of removed 0 aa cleaved  
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) SRLD_ECOLI ( P05707 )
    -  Protein name Sorbitol-6-phosphate 2-dehydrogenase  
    -  Synonyms EC 1.1.1.140, Glucitol-6- phosphate dehydrogenase, Ketosephosphate reductase  
    -  Gene name Name=srlD; Synonyms=gutD; OrderedLocusNames=b2705;  

 Linear View (Whole Mode)
View Location
   2815.0  –  2840.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP srlD (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Oxoacyl-Acp Reductase Of Plasmodium Falciparum  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Sorbitol-6-phosphate 2-dehydrogenase  
         PSI-BLAST 3-oxoacyl-[acyl-carrier-protein] reductase
    nr     (database updated : 2007.02.20 )
         BLAST 3-ketoacyl-(acyl-carrier-protein) reductase [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    PKC_PHOSPHO_SITE    MYRISTYL    PROKAR_LIPOPROTEIN    ATP_GTP_A    ADH_SHORT     

Other Cross-Reference
    COG COG1028IQR 
    EcoCyc srlD 

MMBR References
Mol Gen Genet. 1981;183(3):497-504.
Physical mapping of the srl recA region of Escherichia coli: analysis of Tn10 generated insertions and deletions.
Willis DK, Uhlin BE, Amini KS, Clark AJ. ( 6278241 )
J Biol Chem. 1987;262:5455-5463
Glucitol-specific enzymes of the phosphotransferase system in Escherichia coli.
Yamada, M., and M. H. Saier.
J Bacteriol. 1987;169(7):2990-4.
Physical and genetic characterization of the glucitol operon in Escherichia coli.
Yamada M, Saier MH Jr. ( 3036766 )

Sequences
Amino acid
FASTA format
0001 MNQVAVVIGG GQTLGAFLCH GLAAEGYRVA VVDIQSDKAA NVAQEINAEY GESMAYGFGA DATSEQSVLA 
0071 LSRGVDEIFG RVDLLVYSAG IAKAAFISDF QLGDFDRSLQ VNLVGYFLCA REFSRLMIRD GIQGRIIQIN 
0141 SKSGKVGSKH NSGYSAAKFG GVGLTQSLAL DLAEYGITVH SLMLGNLLKS PMFQSLLPQY ATKLGIKPDQ 
0211 VEQYYIDKVP LKRGCDYQDV LNMLLFYASP KASYCTGQSI NVTGGQVMF

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             CGAAGCGGAA TTTCCGGGCA CTGTCCATGT 
-070 GGCAGGCCCT GTCCCCGACG ATATCGCGCC GGGATCGGTT TTGAAGTTTG AATCTGTTAA GGAGTAAAAA 
0001 atgaatcagg ttgccgttgt catcggtggt gggcaaacct taggcgcgtt cctgtgccac ggtctggctg 
0071 ccgaggggta tcgcgtcgcg gttgtcgata ttcagagcga caaagccgca aatgtggcac aagaaattaa 
0141 cgccgaatat ggtgaaagta tggcgtacgg ttttggtgct gacgccacta gcgagcaaag cgttctggcg 
0211 ctctctcgtg gggtagatga aatctttggt cgcgtggatt tgctggtcta cagcgccgga atagcaaaag 
0281 cagcctttat cagcgacttc cagctcggcg attttgaccg ttcgctacag gtgaatctgg tgggttattt 
0351 cctgtgtgcg cgtgaatttt cgcgtttgat gatccgcgac gggattcagg ggcgcattat tcagatcaac 
0421 tcgaaatccg gcaaagtggg cagcaaacac aactctggct acagcgcagc gaaatttggt ggcgtcgggc 
0491 tgactcaatc actggcgctg gatctggcgg agtacggcat tacggtgcat tcactgatgc tcggtaacct 
0561 gctgaaatcg ccgatgttcc agtcactgtt gccacaatac gcgaccaagc tgggtatcaa accggatcaa 
0631 gtcgagcagt attacatcga caaagtaccg ctcaaacgcg gctgcgatta tcaagatgtg ctgaatatgc 
0701 tgctgttcta cgccagtcct aaggcgtcgt actgcaccgg acagtcgatc aatgtcaccg gcggtcaggt 
0771 gatgttctga TCAACAGCGG AGATCCATTA AGGATCTCCG TGAGACTATA GAATGCCTGA TGCGCTACGC 
0841 TCATCAGGCA TACAGGACTT CCGCCACTAC ATTAAGGAAA