MG1655
W3110
Search for
Japanese | English
Gene Report : srlE
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
J Bacteriol. 1975;124(1):26-38.
Mutations affecting transport of the hexitols D-mannitol, D-glucitol, and galactitol in Escherichia coli K-12: isolation and mapping.
Lengeler J. ( 1100602 )
     Deletion 21 (LD)  ,  DE(recA-srlR)300  ,  OCL47,48-1 (LD 21_CRS) (D)  ,  OCL47,48-2 (LD 21_P/O) (D)  ,  OCL48 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  srlE
Related strains
     Strains Search Search strains by gene name:  srlE   Search strains by all related name:  srlE b2703 ECK2698 gutA gutE JW5430 sbl srlA

General information  (Go to Linear View:)
 Gene Name srlE  
 Alternative name b2703,ECK2698,gutA,gutE,JW5430,sbl,srlA  
 Location, Length 2,824,414 - 2,825,373 (  +  ) ;   60.88 min ; 960 (bp) ,   319 (aa) Go to Linear View
 Product glucitol/sorbitol-specific enzyme IIB component of PTS  
 Operon Name srlAEBD-gutM-srlR-gutQ  
 Note PTS system, glucitol/sorbitol-specific IIB component and second of two IIC components; GO_process: GO:0016052 - carbohydrate catabolic process  
 Function transport; Transport of small molecules: Carbohydrates, organic acids, alcohols  
 Gene Ontology GO:0005351 ; sugar:hydrogen ion symporter activity ( srlA )
GO:0005351 ; sugar:hydrogen ion symporter activity ( srlE )
GO:0005886 ; plasma membrane ( srlA )
GO:0005886 ; plasma membrane ( srlE )
GO:0006810 ; transport ( srlA )
GO:0006810 ; transport ( srlE )
GO:0008643 ; carbohydrate transport ( srlA )
GO:0008643 ; carbohydrate transport ( srlE )
GO:0008982 ; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity ( srlE )
GO:0009401 ; phosphoenolpyruvate-dependent sugar phosphotransferase system ( srlA )
GO:0009401 ; phosphoenolpyruvate-dependent sugar phosphotransferase system ( srlE )
GO:0016020 ; membrane ( srlA )
GO:0016020 ; membrane ( srlE )
GO:0016021 ; integral to membrane ( srlA )
GO:0016021 ; integral to membrane ( srlE )
GO:0016301 ; kinase activity ( srlE )
GO:0016740 ; transferase activity ( srlE )
 PID 48994905  
 EC number
  (KEGG Pathway)
 
2.7.1.69  
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) PTHC_ECOLI ( P56579 ; P05705; P78102; P78214 )
    -  Protein name PTS system, glucitol/sorbitol-specific IIC2 component  
    -  Synonyms EIIC2-Gut, Glucitol/sorbitol-permease IIC2 component, Phosphotransferase enzyme II, C2 component  
    -  Gene name Name=srlA; Synonyms=gutA, sbl; OrderedLocusNames=b2702;  

 Linear View (Whole Mode)
View Location
   2815.0  –  2840.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP srlA (  homologous genes of other bacterias  )   srlE (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, L-Lactate Dehydrogenase (E.C.1.1.1.27) (T-State) Mutant With Cys 199 Replaced By Ser (C199s) Complex With Nadh  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Glucitol/sorbitol-specific phosphotransferase enzyme IIB component  
         PSI-BLAST Glucitol/sorbitol-specific phosphotransferase enzyme IIB component
    nr     (database updated : 2007.02.20 )
         BLAST glucitol/sorbitol-specific enzyme IIB component of PTS [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    GLYCOSAMINOGLYCAN    CAMP_PHOSPHO_SITE    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    AMIDATION    PROTEIN_KINASE_ATP     

Other Cross-Reference
    EcoCyc srlE 

Sequences
Amino acid
FASTA format
0001 MTHIRIEKGT GGWGGPLELK ATPGKKIVYI TAGTRPAIVD KLAQLTGWQA IDGFKEGEPA EAEIGVAVID 
0071 CGGTLRCGIY PKRRIPTINI HSTGKSGPLA QYIVEDIYVS GVKEENITVV GDATPQPSSV GRDYDTSKKI 
0141 TEQSDGLLAK VGMGMGSTVA VLFQSGRDTI DTVLKTILPF MAFVSALIGI IMASGLGDWI AHGLAPLASH 
0211 PLGLVMLALI CSFPLLSPFL GPGAVIAQVI GVLIGVQIGL GNIPPHLALP ALFAINAQAA CDFIPVGLSL 
0281 AEARQDTVRV GVPSVLVSRF LTGAPTVLIA WFVSGFIYQ

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             ATTTCTTCCG CGGCTGGGTG ACCGATCTGA 
-070 CCACCGCCAT TTTTGAGAAA AAGATGGGCA TTCAACTTGA ACAAAAAGTT CACCTGGCAG GAGCAACATC 
0001 atgacgcata ttcggatcga aaaaggaacg ggtggctggg gcggcccgct tgagctgaaa gccacgccgg 
0071 gaaaaaaaat cgtctatatc accgccggta cccggcctgc gattgttgac aaactggcac agcttactgg 
0141 ctggcaggct attgacggat ttaaagaagg tgaacccgcg gaggcggaaa ttggtgtcgc ggtaatcgac 
0211 tgtggcggca cattacgctg cggcatctat ccgaaacgac gtattcccac cattaatatc cactcgacgg 
0281 gcaagtccgg tccgctggcg cagtacattg tggaagatat ttatgtctct ggcgtaaaag aagaaaacat 
0351 cactgtagta ggtgatgcga caccacaacc ctcttccgtg ggccgtgact atgacaccag taagaaaatc 
0421 accgaacaaa gcgatggttt actggcgaag gtgggaatgg gcatggggtc caccgttgcg gtgctgtttc 
0491 aatctggtcg tgacaccatc gacactgtat taaaaaccat tctgccgttt atggcattcg tctcggcgct 
0561 cattggcatc attatggctt ctggccttgg tgactggatt gcccacggtc ttgctccgct ggcgagccat 
0631 ccactgggtc tggtcatgct ggcgctcatc tgttccttcc cactgctttc acctttcctc ggcccaggcg 
0701 cagttatcgc acaggttatc ggcgtattga ttggcgtgca gattggtctc ggcaatattc cgccgcatct 
0771 ggctttaccg gcactgtttg ccatcaacgc gcaggcggcc tgcgacttca tcccggtcgg tttgtcgctg 
0841 gcggaagccc gtcaggacac ggttcgcgtc ggtgtccctt ctgtactggt gagccgcttt ttaaccggcg 
0911 cgccgactgt actgatcgcc tggtttgtct ccggttttat ctatcaatag AGGCTGAAAC ATGACCGTTA 
0981 TTTATCAGAC CACCATCACC CGTATCGGCG CGAGTGCCAT TGACGCCCTC AGTGACCAGA TGCTCATCAC 
1051 CTTTCGTGAA