MG1655
W3110
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Gene Report : srlA
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)  
     Deletion 21 (LD)  ,  DE(recA-srlR)300  ,  OCL47,48-1 (LD 21_CRS) (D)  ,  OCL47,48-2 (LD 21_P/O) (D)  ,  OCL48 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  srlA
Related strains
     Strains Search Search strains by gene name:  srlA   Search strains by all related name:  srlA b2702 ECK2697 gutA JW5429 sbl

General information  (Go to Linear View:)
 Gene Name srlA  
 Alternative name b2702,ECK2697,gutA,JW5429,sbl  
 Location, Length 2,823,854 - 2,824,417 (  +  ) ;   60.86 min ; 564 (bp) ,   187 (aa) Go to Linear View
 Product glucitol/sorbitol-specific enzyme IIC component of PTS  
 Operon Name srlAEBD-gutM-srlR-gutQ  
 Note PTS system, glucitol/sorbitol-specific IIC component, one of two; GO_process: GO:0016052 - carbohydrate catabolic process  
 Function transport; Transport of small molecules: Carbohydrates, organic acids, alcohols  
 Gene Ontology GO:0005351 ; sugar:hydrogen ion symporter activity ( srlA )
GO:0005886 ; plasma membrane ( srlA )
GO:0006810 ; transport ( srlA )
GO:0008643 ; carbohydrate transport ( srlA )
GO:0009401 ; phosphoenolpyruvate-dependent sugar phosphotransferase system ( srlA )
GO:0016020 ; membrane ( srlA )
GO:0016021 ; integral to membrane ( srlA )
 PID 48994904  
 EC number
  (KEGG Pathway)
 
 
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) PTHC_ECOLI ( P56579 ; P05705; P78102; P78214 )
    -  Protein name PTS system, glucitol/sorbitol-specific IIC2 component  
    -  Synonyms EIIC2-Gut, Glucitol/sorbitol-permease IIC2 component, Phosphotransferase enzyme II, C2 component  
    -  Gene name Name=srlA; Synonyms=gutA, sbl; OrderedLocusNames=b2702;  

 Linear View (Whole Mode)
View Location
   2815.0  –  2840.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP srlA (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Pyrococcus Horikoshii Fibrillarin Pre-Rrna Processing Protein  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Glucitol/sorbitol permease IIC component  
         PSI-BLAST Glucitol/sorbitol permease IIC component
    nr     (database updated : 2007.02.20 )
         BLAST glucitol/sorbitol-specific enzyme IIC component of PTS [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE MYRISTYL    PROKAR_LIPOPROTEIN     

Other Cross-Reference
    EcoCyc srlA 

MMBR References
J Bacteriol. 1977;132(1):166-73.
Xylitol and D-arabitol toxicities due to derepressed fructose, galactitol, and sorbitol phosphotransferases of Escherichia coli.
Reiner AM. ( 334721 )
J Gen Microbiol. 1982;128(3):605-11.
A specialized transducing phage, lambda psrlA, for the sorbitol phosphotransferase of Escherichia coli K12.
Boronat A, Jones-Mortimer MC, Kornberg HL. ( 6281366 )
Mol Gen Genet. 1981;183(3):497-504.
Physical mapping of the srl recA region of Escherichia coli: analysis of Tn10 generated insertions and deletions.
Willis DK, Uhlin BE, Amini KS, Clark AJ. ( 6278241 )
J Biol Chem. 1987;262:5455-5463
Glucitol-specific enzymes of the phosphotransferase system in Escherichia coli.
Yamada, M., and M. H. Saier.
J Bacteriol. 1987;169(7):2990-4.
Physical and genetic characterization of the glucitol operon in Escherichia coli.
Yamada M, Saier MH Jr. ( 3036766 )

Sequences
Amino acid
FASTA format
0001 MIETITHGAE WFIGLFQKGG EVFTGMVTGI LPLLISLLVI MNALINFIGQ HRIERFAQRC AGNPVSRYLL 
0071 LPCIGTFVFC NPMTLSLGRF MPEKYKPSYY AAASYSCHSM NGLFPHINPG ELFVYLGIAS GLTTLNLPLG 
0141 PLAVSYLLVG LVTNFFRGWV TDLTTAIFEK KMGIQLEQKV HLAGATS

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             TCTTTCATTT TGCGATCAAA ATAACACTTT 
-070 TAAATCTTTC AATCTGATTA GATTAGGTTG CCGTTTGGTA ATAAAACAAT AAATCCTGAA GGAGAGAACA 
0001 atgatagaaa ccattactca tggtgcagag tggtttatcg ggctgttcca aaagggcgga gaggtgttta 
0071 ccgggatggt gaccggcatt cttccgctgt tgattagcct gctggttatc atgaacgcac tgattaattt 
0141 tatcggtcag catcgtattg aacgttttgc tcaacgttgc gccggtaacc ctgtttcccg ttacctactg 
0211 ttaccgtgca ttggcacgtt tgtcttttgc aatccgatga ccctaagcct gggtcgcttt atgccggaaa 
0281 agtacaaacc cagctactac gcggcggcct cttatagctg ccactcaatg aatggcctct tcccccatat 
0351 caaccctggc gaactgtttg tttatcttgg cattgccagc ggtctgacaa cgctgaacct gccacttggc 
0421 ccactggcgg tgagttatct gctggttggt ctggtcacca atttcttccg cggctgggtg accgatctga 
0491 ccaccgccat ttttgagaaa aagatgggca ttcaacttga acaaaaagtt cacctggcag gagcaacatc 
0561 atgaCGCATA TTCGGATCGA AAAAGGAACG GGTGGCTGGG GCGGCCCGCT TGAGCTGAAA GCCACGCCGG 
0631 GAAAAAAAAT CGTCTATATC ACCGCCGGTA CCCG