MG1655
W3110
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Gene Report : tyrA
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
     Deletion OCL52,53-1 (D)  ,  OCL52-2 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  tyrA
Related strains
     Strains Search Search strains by gene name:  tyrA   Search strains by all related name:  tyrA b2600 ECK2597 JW2581

General information  (Go to Linear View:)
 Gene Name tyrA  
 Alternative name b2600,ECK2597,JW2581  
 Location, Length 2,736,970 - 2,738,091 (  -  ) ;   58.99 min ; 1122 (bp) ,   373 (aa) Go to Linear View
 Product fused chorismate mutase T/prephenate dehydrogenase  
 Operon Name aroF-tyrA  
 Note chorismate mutase-T and prephenate dehydrogenase; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0009094 - L-phenylalanine biosynthetic process; GO_process: GO:0006571 - tyrosine biosynthetic process  
 Function enzyme; Amino acid biosynthesis: Tyrosine  
 Gene Ontology GO:0003824 ; catalytic activity ( tyrA )
GO:0004106 ; chorismate mutase activity ( tyrA )
GO:0004665 ; prephenate dehydrogenase (NADP+) activity ( tyrA )
GO:0005488 ; binding ( tyrA )
GO:0005737 ; cytoplasm ( tyrA )
GO:0006571 ; tyrosine biosynthetic process ( tyrA )
GO:0008152 ; metabolic process ( tyrA )
GO:0008652 ; amino acid biosynthetic process ( tyrA )
GO:0008977 ; prephenate dehydrogenase activity ( tyrA )
GO:0009073 ; aromatic amino acid family biosynthetic process ( tyrA )
GO:0016491 ; oxidoreductase activity ( tyrA )
GO:0016853 ; isomerase activity ( tyrA )
 PID 1788952  
 EC number
  (KEGG Pathway)   		1.3.1.12   5.4.99.5  
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) TYRA_ECOLI ( P07023 ; P78205; P78206 )
    -  Protein name T-protein  
    -  Synonyms  
    -  Gene name Name=tyrA; OrderedLocusNames=b2600;  

 Linear View (Whole Mode)
View Location
   2725.0  –  2750.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP tyrA (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Structure Of Chorismate Mutase (Form I) From Thermus Thermophilus Hb8  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST T-protein [Includes: Chorismate mutase  
         PSI-BLAST Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase ; Methenyltetrahydrofolate cyclohydrolase ]
    nr     (database updated : 2007.02.20 )
         BLAST fused chorismate mutase T/prephenate dehydrogenase [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    AMIDATION     

Other Cross-Reference
    COG COG0287E  COG1605E 
    EcoCyc tyrA 

MMBR References
J Mol Biol. 1984;180(4):1023-51.
Nucleotide sequence and transcription of the phenylalanine and tyrosine operons of Escherichia coli K12.
Hudson GS, Davidson BE. ( 6396419 )
J Bacteriol. 1971;107(1):8-15.
Regulation of tyrosine biosynthesis in Escherichia coli K-12: isolation and characterization of operator mutants.
Mattern IE, Pittard J. ( 4397929 )

Sequences
Amino acid
FASTA format 
0001 MVAELTALRD QIDEVDKALL NLLAKRLELV AEVGEVKSRF GLPIYVPERE ASMLASRRAE AEALGVPPDL 
0071 IEDVLRRVMR ESYSSENDKG FKTLCPSLRP VVIVGGGGQM GRLFEKMLTL SGYQVRILEQ HDWDRAADIV 
0141 ADAGMVIVSV PIHVTEQVIG KLPPLPKDCI LVDLASVKNG PLQAMLVAHD GPVLGLHPMF GPDSGSLAKQ 
0211 VVVWCDGRKP EAYQWFLEQI QVWGARLHRI SAVEHDQNMA FIQALRHFAT FAYGLHLAEE NVQLEQLLAL 
0281 SSPIYRLELA MVGRLFAQDP QLYADIIMSS ERNLALIKRY YKRFGEAIEL LEQGDKQAFI DSFRKVEHWF 
0351 GDYAQRFQSE SRVLLRQAND NRQ
Nucleotide
FASTA format

View sequence out neighbor 100bp 
-100                                             gatgcctgca ttagctggga aatgaccgat 
-070 gccttgctgc gtgaaattca tcaggatctg aacgggcagc tgacggctcg cgtggcttaa gaggtttatt 
0001 atggttgctg aattgaccgc attacgcgat caaattgatg aagtcgataa agcgctgctg aatttattag 
0071 cgaagcgtct ggaactggtt gctgaagtgg gcgaggtgaa aagccgcttt ggactgccta tttatgttcc 
0141 ggagcgcgag gcatctatgt tggcctcgcg tcgtgcagag gcggaagctc tgggtgtacc gccagatctg 
0211 attgaggatg ttttgcgtcg ggtgatgcgt gaatcttact ccagtgaaaa cgacaaagga tttaaaacac 
0281 tttgtccgtc actgcgtccg gtggttatcg tcggcggtgg cggtcagatg ggacgcctgt tcgagaagat 
0351 gctgaccctc tcgggttatc aggtgcggat tctggagcaa catgactggg atcgagcggc tgatattgtt 
0421 gccgatgccg gaatggtgat tgttagtgtg ccaatccacg ttactgagca agttattggc aaattaccgc 
0491 ctttaccgaa agattgtatt ctggtcgatc tggcatcagt gaaaaatggg ccattacagg ccatgctggt 
0561 ggcgcatgat ggtccggtgc tggggctaca cccgatgttc ggtccggaca gcggtagcct ggcaaagcaa 
0631 gttgtggtct ggtgtgatgg acgtaaaccg gaagcatacc aatggtttct ggagcaaatt caggtctggg 
0701 gcgctcggct gcatcgtatt agcgccgtcg agcacgatca gaatatggcg tttattcagg cactgcgcca 
0771 ctttgctact tttgcttacg ggctgcacct ggcagaagaa aatgttcagc ttgagcaact tctggcgctc 
0841 tcttcgccga tttaccgcct tgagctggcg atggtcgggc gactgtttgc tcaggatccg cagctttatg 
0911 ccgacatcat tatgtcgtca gagcgtaatc tggcgttaat caaacgttac tataagcgtt tcggcgaggc 
0981 gattgagttg ctggagcagg gcgataagca ggcgtttatt gacagtttcc gcaaggtgga gcactggttc 
1051 ggcgattacg cacagcgttt tcagagtgaa agccgcgtgt tattgcgtca ggcgaatgac aatcgccagt 
1121 aataatccag tgccggatga ttcacatcat ccggcacctt ttcatcaggt tggatcaaca ggcactacgt 
1191 tctcacttgg gtaacagccc aataccttca tt