|
PEC Original Annotations
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Essentiality
|
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Class
|
essential
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|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
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Deletion
|
OCL58
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
dapA
|
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Related strains
|
|
Strains Search
|
Search strains by gene name:
dapA
Search strains by all related name:
dapA b2478 ECK2474 JW2463
|
General information (Go to Linear View: )
|
|
Gene Name
|
dapA
|
|
Alternative name
|
b2478,ECK2474,JW2463
|
|
Location, Length
|
2,596,904 - 2,597,782
(
-
)
;
55.97
min
;
879
(bp) ,
292
(aa)
|
|
Product
|
dihydrodipicolinate synthase
|
|
Operon Name
|
dapA-bamC
|
|
Note
|
GO_component: GO:0005737 - cytoplasm; GO_process: GO:0009089 - lysine biosynthetic process via diaminopimelate
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Function
|
enzyme; Amino acid biosynthesis: Lysine
|
|
Gene Ontology
|
GO:0003824
;
catalytic activity ( dapA )
GO:0005737
;
cytoplasm ( dapA )
GO:0008152
;
metabolic process ( dapA )
GO:0008652
;
amino acid biosynthetic process ( dapA )
GO:0008840
;
dihydrodipicolinate synthase activity ( dapA )
GO:0009085
;
lysine biosynthetic process ( dapA )
GO:0016829
;
lyase activity ( dapA )
GO:0019877
;
diaminopimelate biosynthetic process ( dapA )
|
|
PID
|
1788823
|
EC number
(KEGG Pathway)
|
4.2.1.52
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
dapA
(
EG10205
)
|
|
Number of removed
|
0 aa cleaved
|
|
SWISS-PROT
(
Show details
[
1
more]
)
|
Entry name(Acc.no)
|
DAPA_ECOLI
(
P05640
;
P78223
)
|
|
- Protein name
|
Dihydrodipicolinate synthase
|
|
- Synonyms
|
EC 4.2.1.52, DHDPS
|
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- Gene name
|
Name=dapA; OrderedLocusNames=b2478, SF2521, S2671;
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Homology Analysis
|
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BLAST
|
|
Bacteria
|
|
GTOP
|
dapA
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Dihydrodipicolinate Synthase
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Dihydrodipicolinate synthase (DHDPS)
|
|
PSI-BLAST
|
Dihydrodipicolinate synthase
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
dihydrodipicolinate synthase [Escherichia coli K12]
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Pfam 28.0
(database updated :
2015-05
)
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Pfam
|
|
|
PROSITE
|
|
PROSITE
|
ASN_GLYCOSYLATION
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
TYR_PHOSPHO_SITE
MYRISTYL
TONB_DEPENDENT_REC_1
DHDPS_1
DHDPS_2
|
|
MMBR References
|
J Bacteriol. 1986;166(1):297-300.
Chromosomal location and nucleotide sequence of the Escherichia coli dapA gene.
Richaud F, Richaud C, Ratet P, Patte JC.
(
3514578
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MFTGSIVAIV TPMDEKGNVC RASLKKLIDY HVASGTSAIV SVGTTGESAT LNHDEHADVV MMTLDLADGR
0071 IPVIAGTGAN ATAEAISLTQ RFNDSGIVGC LTVTPYYNRP SQEGLYQHFK AIAEHTDLPQ ILYNVPSRTG
0141 CDLLPETVGR LAKVKNIIGI KEATGNLTRV NQIKELVSDD FVLLSGDDAS ALDFMQLGGH GVISVTANVA
0211 ARDMAQMCKL AAEGHFAEAR VINQRLMPLH NKLFVEPNPI PVKWACKELG LVATDTLRLP MTPITDSGRE
0281 TVRAALKHAG LL
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 aaaaaaacat gcatacaaca atcagaacgg
-070 ttctgtctgc ttgcttttaa tgccatacca aacgtaccat tgagacactt gtttgcacag aggatggccc
0001 atgttcacgg gaagtattgt cgcgattgtt actccgatgg atgaaaaagg taatgtctgt cgggctagct
0071 tgaaaaaact gattgattat catgtcgcca gcggtacttc ggcgatcgtt tctgttggca ccactggcga
0141 gtccgctacc ttaaatcatg acgaacatgc tgatgtggtg atgatgacgc tggatctggc tgatgggcgc
0211 attccggtaa ttgccgggac cggcgctaac gctactgcgg aagccattag cctgacgcag cgcttcaatg
0281 acagtggtat cgtcggctgc ctgacggtaa ccccttacta caatcgtccg tcgcaagaag gtttgtatca
0351 gcatttcaaa gccatcgctg agcatactga cctgccgcaa attctgtata atgtgccgtc ccgtactggc
0421 tgcgatctgc tcccggaaac ggtgggccgt ctggcgaaag taaaaaatat tatcggaatc aaagaggcaa
0491 cagggaactt aacgcgtgta aaccagatca aagagctggt ttcagatgat tttgttctgc tgagcggcga
0561 tgatgcgagc gcgctggact tcatgcaatt gggcggtcat ggggttattt ccgttacggc taacgtcgca
0631 gcgcgtgata tggcccagat gtgcaaactg gcagcagaag ggcattttgc cgaggcacgc gttattaatc
0701 agcgtctgat gccattacac aacaaactat ttgtcgaacc caatccaatc ccggtgaaat gggcatgtaa
0771 ggaactgggt cttgtggcga ccgatacgct gcgcctgcca atgacaccaa tcaccgacag tggtcgtgag
0841 acggtcagag cggcgcttaa gcatgccggt ttgctgtaaa gtttagggag atttgatggc ttactctgtt
0911 caaaagtcgc gcctggcaaa ggttgcgggt gtttcgcttg ttttattact cgctgcctgt agttctgac
|
