|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
|
Deletion
|
OCL58
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
purC
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
purC
Search strains by all related name:
purC ade b2476 ECK2472 JW2461
|
General information (Go to Linear View: )
|
|
Gene Name
|
purC
|
|
Alternative name
|
ade,b2476,ECK2472,JW2461
|
|
Location, Length
|
2,594,927 - 2,595,640
(
-
)
;
55.93
min
;
714
(bp) ,
237
(aa)
|
|
Product
|
phosphoribosylaminoimidazole-succinocarboxamide synthetase
|
|
Operon Name
|
purC
|
|
Note
|
phosphoribosylaminoimidazole-succinocarboxamide synthetase = SAICAR synthetase; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0006164 - purine nucleotide biosynthetic process
|
|
Function
|
enzyme; Purine ribonucleotide biosynthesis
|
|
Gene Ontology
|
GO:0000034
;
adenine deaminase activity ( ade )
GO:0003824
;
catalytic activity ( purC )
GO:0004639
;
phosphoribosylaminoimidazolesuccinocarboxamide synthase activity ( purC )
GO:0005515
;
protein binding ( purC )
GO:0005524
;
ATP binding ( purC )
GO:0005624
;
membrane fraction ( purC )
GO:0006146
;
adenine catabolic process ( ade )
GO:0006164
;
purine nucleotide biosynthetic process ( purC )
GO:0016787
;
hydrolase activity ( ade )
GO:0016810
;
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds ( ade )
GO:0016874
;
ligase activity ( purC )
GO:0030145
;
manganese ion binding ( ade )
|
|
PID
|
1788820
|
EC number
(KEGG Pathway)
|
6.3.2.6
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
purC
(
EG10791
)
|
|
Number of removed
|
0 aa cleaved
|
|
SWISS-PROT
(
Show details
)
|
Entry name(Acc.no)
|
PUR7_ECOLI
(
P21155
)
|
|
- Protein name
|
Phosphoribosylaminoimidazole-succinocarboxamide synthase
|
|
- Synonyms
|
EC 6.3.2.6, SAICAR synthetase
|
|
- Gene name
|
OrderedLocusNames=b2476, c3004, z3735, ECs3338, SF2519, S2669;
|
|
MMBR References
|
J Bacteriol. 1990;172(3):1173
Location of purine genes on the physical map of Escherichia coli.
Masters M.
(
2407714
)
|
J Bacteriol. 1984;157(3):712-7.
Identification of the purC gene product of Escherichia coli.
Parker J.
(
6365889
)
|
J Bacteriol. 1990;172(10):6035-41.
DNA sequence of the purC gene encoding 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide synthetase and organization of the dapA-purC region of Escherichia coli K-12.
Tiedeman AA, DeMarini DJ, Parker J, Smith JM.
(
2120198
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MQKQAELYRG KAKTVYSTEN PDLLVLEFRN DTSAGDGARI EQFDRKGMVN NKFNYFIMSK LAEAGIPTQM
0071 ERLLSDTECL VKKLDMVPVE CVVRNRAAGS LVKRLGIEEG IELNPPLFDL FLKNDAMHDP MVNESYCETF
0141 GWVSKENLAR MKELTYKAND VLKKLFDDAG LILVDFKLEF GLYKGEVVLG DEFSPDGSRL WDKETLEKMD
0211 KDRFRQSLGG LIEAYEAVAR RLGVQLD
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 gtagttcgga taaggcgttc acgccgcatc
-070 cgacaaaaca tccggcacac cagacagcaa aagattttaa aacgttaatt cacacccagg agtgataaag
0001 atgcaaaagc aagctgagtt gtatcgtggt aaagcgaaaa ccgtatacag cacggaaaac ccggacctgt
0071 tggtgctcga attccgcaat gatacgtcag caggggatgg cgcgcgcatt gagcagtttg atcgcaaagg
0141 tatggtgaac aacaagttca actacttcat tatgagcaaa ctggctgaag cgggtatccc gactcaaatg
0211 gagcgtctgc tctccgatac cgaatgtctg gtgaaaaagc tggatatggt gccggttgag tgtgtcgtgc
0281 gtaaccgtgc tgctggctct ctggtgaaac gtcttggaat cgaagaaggt attgagctga acccgccgct
0351 gttcgatctg ttcctgaaaa acgacgccat gcacgatccg atggtcaacg aatcttactg cgaaaccttt
0421 ggctgggtga gcaaagagaa cctggcgcgt atgaaagagc tgacctacaa agcgaacgac gtgctgaaaa
0491 aactgttcga tgatgctggt ctgattctgg tcgacttcaa gctggaattt ggtctgtaca aaggcgaagt
0561 ggtactgggt gatgagttct ccccggacgg tagccgcctg tgggacaaag aaacgctgga gaaaatggac
0631 aaagaccgtt tccgccagag cctcggtggc ctgatcgaag cctatgaagc cgtcgcccgc cgcctgggtg
0701 tacagctgga ctgatttttc tgttcatcat cttgccgtgc agctggcacg gcaagacaac cgctctcgga
0771 atatatgcat tgaacgctca ttcctccgcc atttcatccc gctt
|
