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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
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Deletion
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DE(ptsI-cysA)137
,
OCL60-6
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
crr
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Related strains
|
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Strains Search
|
Search strains by gene name:
crr
Search strains by all related name:
crr b2417 ECK2412 gsr iex JW2410 tgs treD
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General information (Go to Linear View: )
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Gene Name
|
crr
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Alternative name
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b2417,ECK2412,gsr,iex,JW2410,tgs,treD
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Location, Length
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2,533,856 - 2,534,365
(
+
)
;
54.61
min
;
510
(bp) ,
169
(aa)
|
|
Product
|
glucose-specific enzyme IIA component of PTS
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Operon Name
|
ptsHI-crr
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Note
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PTS system, glucose-specific IIA component; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0016052 - carbohydrate catabolic process
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Function
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enzyme; Transport of small molecules: Carbohydrates, organic acids, alcohols
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Gene Ontology
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GO:0005351
;
sugar:hydrogen ion symporter activity ( crr )
GO:0005515
;
protein binding ( crr )
GO:0005624
;
membrane fraction ( crr )
GO:0005737
;
cytoplasm ( crr )
GO:0006810
;
transport ( crr )
GO:0008270
;
zinc ion binding ( crr )
GO:0008643
;
carbohydrate transport ( crr )
GO:0009401
;
phosphoenolpyruvate-dependent sugar phosphotransferase system ( crr )
GO:0016020
;
membrane ( crr )
GO:0016301
;
kinase activity ( crr )
GO:0016740
;
transferase activity ( crr )
GO:0046872
;
metal ion binding ( crr )
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PID
|
1788757
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EC number
(KEGG Pathway)
|
2.7.1.69
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|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
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EcoGene
|
crr
(
EG10165
)
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Number of removed
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1 aa cleaved
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SWISS-PROT
(
Show details
[
2
more]
)
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Entry name(Acc.no)
|
PTGA_ECOLI
(
P08837
;
Q47703
)
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- Protein name
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PTS system, glucose-specific IIA component
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- Synonyms
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EIIA-Glc, Glucose- permease IIA component, Phosphotransferase enzyme II, A component, EC 2.7.1.69, EIII-Glc
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- Gene name
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OrderedLocusNames=b2417, c2952, SF2472, S2618;
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MMBR References
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EMBO J.;15:6408-6415.
TolA central domain interacts with Escherichia coli porins.
Derouiche, R., M. Gavioli, H. Benedetti, A. Prilipov, C. Lazdunski, and R. Lloubes.
|
FEBS Lett. 1978;89:329-332.
Roles of crr-gene products in regulating carbohydrate uptake by Escherichia coli.
Kornberg, H. L., and P. D. Watts.
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Proc Natl Acad Sci U S A. 1982;79:2528-2532
Molecular cloning of the crr gene and evidence that it is the structural gene for IIIGlc, a phosphocarrier protein of the bacterial phosphotransferase system.
Meadow, N. D., D. W. Saffen, R. P. Dottin, and S. Roseman.
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J Bacteriol. 1984;160(1):360-4.
Role of IIIGlc of the phosphoenolpyruvate-glucose phosphotransferase system in inducer exclusion in Escherichia coli.
Nelson SO, Lengeler J, Postma PW.
(
6384197
)
|
J Gen Microbiol. 1983;129(2):337-48.
Phosphotransferase-mediated regulation of carbohydrate utilization in Escherichia coli K12: the nature of the iex (crr) and gsr (tgs) mutations.
Parra F, Jones-Mortimer MC, Kornberg HL.
(
6302201
)
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J Gen Microbiol. 1983;129(2):357-8.
Two separate genes involved in sulphate transport in Escherichia coli K12.
Parra F, Britton P, Castle C, Jones-Mortimer MC, Kornberg HL.
(
6341507
)
|
J Biol Chem. 1987;262:16241-16253
Sugar transport by the bacterial phosphotransferase system. Molecular cloning and structural analysis of the Escherichia coli ptsH, ptsI and crr genes.
Saffen, D. W., K. A. Presper, T. L. Doering, and S. Roseman.
|
J Gen Microbiol. 1983;129(2):349-56.
Phosphotransferase-mediated regulation of carbohydrate utilization in Escherichia coli K12: location of the gsr (tgs) and iex (crr) genes by specialized transduction.
Britton P, Boronat A, Hartley DA, Jones-Mortimer MC, Kornberg HL, Parra F.
(
6302202
)
|
J Mol Biol. 1990;214(4):825-43.
Precise mapping and comparison of two evolutionarily related regions of the Escherichia coli K-12 chromosome. Evolution of valU and lysT from an ancestral tRNA operon.
Brun YV, Breton R, Lanouette P, Lapointe J.
(
2201776
)
|
J Biol Chem. 1992;267:3847-3851
The glucose transporter of Escherichia coli. Mutants with impaired translocation activity that retain phosphorylation activity.
Buhr, A., G. A. Daniels, and B. Erni.
|
Sov. Genet. (Engl. Transl. Genetika) 1980;16:622-629.
Study of linkage with pts genes of pleiotropic mutation affecting expression of catabolite-sensitive genes in Escherichia coli K-12.
Burd, G. I., T. R. Gabrielyan, T. N. Bol'shakova, and V. N. Gershanovich.
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J Bacteriol. 1988;170(9):3827-37.
The ptsH, ptsI, and crr genes of the Escherichia coli phosphoenolpyruvate-dependent phosphotransferase system: a complex operon with several modes of transcription.
De Reuse H, Danchin A.
(
2457575
)
|
Gene. 1984;32(1-2):31-40.
Analysis of the ptsH-ptsI-crr region in Escherichia coli K-12: evidence for the existence of a single transcriptional unit.
De Reuse H, Huttner E, Danchin A.
(
6099314
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MGLFDKLKSL VSDDKKDTGT IEIIAPLSGE IVNIEDVPDV VFAEKIVGDG IAIKPTGNKM VAPVDGTIGK
0071 IFETNHAFSI ESDSGVELFV HFGIDTVELK GEGFKRIAEE GQRVKVGDTV IEFDLPLLEE KAKSTLTPVV
0141 ISNMDEIKEL IKLSGSVTVG ETPVIRIKK
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 ACAACGGACG AGTTAATGAC GCTGGTTAAC
-070 AAGTTCATTG AAGAAAAAAC AATCTGCTAA TCCACGAGAT GCGGCCCAAT TTACTGCTTA GGAGAAGATC
0001 atgggtttgt tcgataaact gaaatctctg gtttccgacg acaagaagga taccggaact attgagatca
0071 ttgctccgct ctctggcgag atcgtcaata tcgaagacgt gccggatgtc gtttttgcgg aaaaaatcgt
0141 tggtgatggt attgctatca aaccaacggg taacaaaatg gtcgcgccag tagacggcac cattggtaaa
0211 atctttgaaa ccaaccacgc attctctatc gaatctgata gcggcgttga actgttcgtc cacttcggta
0281 tcgacaccgt tgaactgaaa ggcgaaggct tcaagcgtat tgctgaagaa ggtcagcgcg tgaaagttgg
0351 cgatactgtc attgaatttg atctgccgct gctggaagag aaagccaagt ctaccctgac tccggttgtt
0421 atctccaaca tggacgaaat caaagaactg atcaaactgt ccggtagcgt aaccgtgggt gaaaccccgg
0491 ttatccgcat caagaagtaa TTCTTGCCGC AGTGAAAAAT GGCGCCCATC GGCGCCATTT TTTTATGCTT
0561 CCGCCAGCGG CGGCAAAATC AATTCATCGC TCTCATGCTG CTGGGTGTAG
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