|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
Proc Natl Acad Sci U S A. 1990;87(1):360-3.
Mutations in the bglY gene increase the frequency of spontaneous deletions in Escherichia coli K-12.
Lejeune P, Danchin A.
(
2404280
)
|
|
|
Deletion
|
DE(ptsI-cysK)
,
OCL60-6
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
ptsH
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
ptsH
Search strains by all related name:
ptsH b2415 ctr ECK2410 Hpr iex? JW2408
|
General information (Go to Linear View: )
|
|
Gene Name
|
ptsH
|
|
Alternative name
|
b2415,ctr,ECK2410,Hpr,iex?,JW2408
|
|
Location, Length
|
2,531,786 - 2,532,043
(
+
)
;
54.57
min
;
258
(bp) ,
85
(aa)
|
|
Product
|
phosphohistidinoprotein-hexose phosphotransferase component of PTS system (Hpr)
|
|
Operon Name
|
ptsHI-crr
|
|
Note
|
PTS system protein HPr; GO_process: GO:0016052 - carbohydrate catabolic process
|
|
Function
|
enzyme; Transport of small molecules: Carbohydrates, organic acids, alcohols
|
|
Gene Ontology
|
GO:0005351
;
sugar:hydrogen ion symporter activity ( ptsH )
GO:0005515
;
protein binding ( ptsH )
GO:0005737
;
cytoplasm ( ptsH )
GO:0006810
;
transport ( ptsH )
GO:0008643
;
carbohydrate transport ( ptsH )
GO:0009401
;
phosphoenolpyruvate-dependent sugar phosphotransferase system ( ptsH )
|
|
PID
|
1788755
|
EC number
(KEGG Pathway)
|
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
ptsH
(
EG10788
)
|
|
Number of removed
|
0 aa cleaved
|
|
SWISS-PROT
(
Show details
[
1
more]
)
|
Entry name(Acc.no)
|
PTHP_ECOLI
(
P07006
;
P05525
)
|
|
- Protein name
|
Phosphocarrier protein HPr
|
|
- Synonyms
|
Histidine-containing protein
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|
- Gene name
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t0426, SF2470, S2616;
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Homology Analysis
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BLAST
|
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Bacteria
|
|
GTOP
|
ptsH
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Solution Structure Of Histidine Containing Protein
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Phosphocarrier protein HPr (Histidine-containing protein)
|
|
PSI-BLAST
|
Phosphocarrier protein HPr
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
PTS system protein HPr [Escherichia coli O157:H7 EDL933]
|
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Pfam 28.0
(database updated :
2015-05
)
|
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Pfam
|
|
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PROSITE
|
|
PROSITE
|
PKC_PHOSPHO_SITE
MYRISTYL
PTS_HPR_HIS
PTS_HPR_SER
|
|
MMBR References
|
FEBS Lett. 1995;374(2):161-4.
Investigation of transphosphorylation between chemotaxis proteins and the phosphoenolpyruvate:sugar phosphotransferase system.
Johnson MS, Rowsell EH, Taylor BL.
(
7589525
)
|
Proc Natl Acad Sci U S A. 1995;92:11583-11587
Coupling the phosphotransferase system and the methyl-accepting chemotaxis protein-dependent chemotaxis signaling pathways of Escherichia coli.
Lux, R., K. Jahreis, K. Bettenbrock, J. S. Parkinson, and J. W. Lengeler.
|
J Gen Microbiol. 1983;129(2):337-48.
Phosphotransferase-mediated regulation of carbohydrate utilization in Escherichia coli K12: the nature of the iex (crr) and gsr (tgs) mutations.
Parra F, Jones-Mortimer MC, Kornberg HL.
(
6302201
)
|
J Biol Chem. 1987;262:16241-16253
Sugar transport by the bacterial phosphotransferase system. Molecular cloning and structural analysis of the Escherichia coli ptsH, ptsI and crr genes.
Saffen, D. W., K. A. Presper, T. L. Doering, and S. Roseman.
|
Biochemistry. 1996;35(35):11268-77.
Influence of N-cap mutations on the structure and stability of Escherichia coli HPr.
Thapar R, Nicholson EM, Rajagopal P, Waygood EB, Scholtz JM, Klevit RE.
(
8784180
)
|
J Gen Microbiol. 1983;129(2):349-56.
Phosphotransferase-mediated regulation of carbohydrate utilization in Escherichia coli K12: location of the gsr (tgs) and iex (crr) genes by specialized transduction.
Britton P, Boronat A, Hartley DA, Jones-Mortimer MC, Kornberg HL, Parra F.
(
6302202
)
|
EMBO J. 1982;1(8):907-11.
Phosphotransferase-mediated regulation of carbohydrate utilisation in Escherichia coli K12: identification of the products of genes on the specialised transducing phages lambda iex (crr) and lambda gsr (tgs).
Britton P, Murfitt D, Parra F, Jones-Mortimer MC, Kornberg HL.
(
6234165
)
|
J Gen Microbiol. 1984;130(4):861-8.
Location and direction of transcription of the ptsH and ptsI genes on the Escherichia coli K12 genome.
Britton P, Lee LG, Murfitt D, Boronat A, Jones-Mortimer MC, Kornberg HL.
(
6330287
)
|
J Bacteriol. 1988;170(9):3827-37.
The ptsH, ptsI, and crr genes of the Escherichia coli phosphoenolpyruvate-dependent phosphotransferase system: a complex operon with several modes of transcription.
De Reuse H, Danchin A.
(
2457575
)
|
J Mol Biol. 1992;226(3):623-35.
Positive regulation of the expression of the Escherichia coli pts operon. Identification of the regulatory regions.
De Reuse H, Kolb A, Danchin A.
(
1324322
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MFQQEVTITA PNGLHTRPAA QFVKEAKGFT SEITVTSNGK SASAKSLFKL QTLGLTQGTV VTISAEGEDE
0071 QKAVEHLVKL MAELE
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 CGCGTCTGTT AAAAACTGGC GCTAACAATA
-070 CAGGCTAAAG TCGAACCGCC AGGCTAGACT TTAGTTCCAC AACACTAAAC CTATAAGTTG GGGAAATACA
0001 atgttccagc aagaagttac cattaccgct ccgaacggtc tgcacacccg ccctgctgcc cagtttgtaa
0071 aagaagctaa gggcttcact tctgaaatta ctgtgacttc caacggcaaa agcgccagcg cgaaaagcct
0141 gtttaaactg cagactctgg gcctgactca aggtaccgtt gtgactatct ccgcagaagg cgaagacgag
0211 cagaaagcgg ttgaacatct ggttaaactg atggcggaac tcgagtaaTT TCCCGGGTTC TTTTAAAAAT
0281 CAGTCACAAG TAAGGTAGGG TTATGATTTC AGGCATTTTA GCATCCCCGG GTATCGCTTT CGGTAAAGCT
0351 CTGCTTCT
|
