|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
|
Deletion
|
DE(lpcA-proB)70
,
OCR36,37-1
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
gpt
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
gpt
Search strains by all related name:
gpt b0238 ECK0239 glyD gpp gxu JW0228
|
General information (Go to Linear View: )
|
|
Gene Name
|
gpt
|
|
Alternative name
|
b0238,ECK0239,glyD,gpp,gxu,JW0228
|
|
Location, Length
|
255,977 - 256,435
(
+
)
;
5.52
min
;
459
(bp) ,
152
(aa)
|
|
Product
|
guanine-hypoxanthine phosphoribosyltransferase
|
|
Operon Name
|
gpt
|
|
Note
|
GO_component: GO:0005737 - cytoplasm; GO_process: GO:0015949 - nucleobase, nucleoside and nucleotide interconversion
|
|
Function
|
enzyme; Salvage of nucleosides and nucleotides
|
|
Gene Ontology
|
GO:0000287
;
magnesium ion binding ( gpt )
GO:0000310
;
xanthine phosphoribosyltransferase activity ( gpt )
GO:0005515
;
protein binding ( gpt )
GO:0005737
;
cytoplasm ( gpt )
GO:0006166
;
purine ribonucleoside salvage ( gpt )
GO:0009116
;
nucleoside metabolic process ( gpt )
GO:0016740
;
transferase activity ( gpt )
GO:0016757
;
transferase activity, transferring glycosyl groups ( gpt )
GO:0046872
;
metal ion binding ( gpt )
|
|
PID
|
1786433
|
EC number
(KEGG Pathway)
|
2.4.2.22
|
|
SWISS-PROT
(
Show details
[
3
more]
)
|
Entry name(Acc.no)
|
XGPT_ECOLI
(
P00501
)
|
|
- Protein name
|
Xanthine-guanine phosphoribosyltransferase
|
|
- Synonyms
|
EC 2.4.2.22, XGPRT
|
|
- Gene name
|
OrderedLocusNames=b0238, z0299, ECs0265, SF0286, S0307;
|
|
Homology Analysis
|
|
BLAST
|
|
Bacteria
|
|
GTOP
|
gpt
(
homologous genes of other bacterias
)
gpp
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Xprtase From E. Coli
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Xanthine phosphoribosyltransferase (Xanthine-guanine phosphoribosyltransferase) (XGPRT)
|
|
PSI-BLAST
|
Xanthine phosphoribosyltransferase (Xanthine-guanine phosphoribosyltransferase) (XGPRT)
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
protein gpt
|
|
Pfam 28.0
(database updated :
2015-05
)
|
|
Pfam
|
|
|
PROSITE
|
|
PROSITE
|
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
PUR_PYR_PR_TRANSFER
|
|
MMBR References
|
J Bacteriol. 1972;112(2):910-6.
Genetic separation of hypoxanthine and guanine-xanthine phosphoribosyltransferase activities by deletion mutations in Salmonella typhimurium.
Gots JS, Benson CE, Shumas SR.
(
4563984
)
|
J Bacteriol. 1991;173(23):7407-8.
Locations of the genes from pepD through proA on the physical map of the Escherichia coli chromosome.
Henrich B, Plapp R.
(
1938933
)
|
Gene. 1984;31(1-3):309-13.
Nucleotide sequence and analysis of deletion mutants of the Escherichia coli gpt gene in plasmid pSV2 gpt.
Jagadeeswaran P, Ashman CR, Roberts S, Langenberg J.
(
6396164
)
|
Gene. 1984;32(1-2):243-9.
Structural and functional organization of the gpt gene region of Escherichia coli.
Nuesch J, Schumperli D.
(
6397401
)
|
Nucleic Acids Res. 1983;11:8817-8823
Nucleotide sequence of the Escherichia coli xanthine-guanine phosphoribosyl transferase gene.
Pratt, D., and S. Subramani.
|
Nucleic Acids Res. 1983;11:8809-8816
Nucleotide sequence of the xanthine guanine phosphoribosyl transferase gene of E. coli.
Richardson, K. K., J. Fostel, and T. R. Skopek.
|
J Gen Microbiol. 1984;130(10):2489-95.
Potentiation by purines of the growth-inhibitory effects of sulphonamides on Escherichia coli K12 and the location of the gene which mediates this effect.
Bruce I, Hardy J, Stacey KA.
(
6392473
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MSEKYIVTWD MLQIHARKLA SRLMPSEQWK GIIAVSRGGL VPGALLAREL GIRHVDTVCI SSYDHDNQRE
0071 LKVLKRAEGD GEGFIVIDDL VDTGGTAVAI REMYPKAHFV TIFAKPAGRP LVDDYVVDIP QDTWIEQPWD
0141 MGVVFVPPIS GR
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 AATACTGGTT TTTAGTGCGC CAGATCTCTA
-070 TAATCTCGCG CAACCTATTT TCCCCTCGAA CACTTTTTAA GCCGTAGATA AACAGGCTGG GACACTTCAC
0001 atgagcgaaa aatacatcgt cacctgggac atgttgcaga tccatgcacg taaactcgca agccgactga
0071 tgccttctga acaatggaaa ggcattattg ccgtaagccg tggcggtctg gtaccgggtg cgttactggc
0141 gcgtgaactg ggtattcgtc atgtcgatac cgtttgtatt tccagctacg atcacgacaa ccagcgcgag
0211 cttaaagtgc tgaaacgcgc agaaggcgat ggcgaaggct tcatcgttat tgatgacctg gtggataccg
0281 gtggtactgc ggttgcgatt cgtgaaatgt atccaaaagc gcactttgtc accatcttcg caaaaccggc
0351 tggtcgtccg ctggttgatg actatgttgt tgatatcccg caagatacct ggattgaaca gccgtgggat
0421 atgggcgtcg tattcgtccc gccaatctcc ggtcgctaaT CTTTTCAACG CCTGGCACTG CCGGGCGTTG
0491 TTCTTTTTAA CTTCAGGCGG GTTACAATAG TTTCCAGTAA GTATTCTGGA GGCTGCATCC ATGACACAG
|
