|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
Int J Pept Protein Res. 1979;13(2):146-51.
Soluble di- and aminopeptidases in Escherichia K-12. Dispensible enzymes.
Hermsdorf CL, Simmonds S, Saunders A.
(
372108
)
|
|
|
Deletion
|
DE(lpcA-proB)70
,
OCR36,37-1
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
pepD
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
pepD
Search strains by all related name:
pepD b0237 ECK0238 JW0227 pepH
|
General information (Go to Linear View: )
|
|
Gene Name
|
pepD
|
|
Alternative name
|
b0237,ECK0238,JW0227,pepH
|
|
Location, Length
|
254,259 - 255,716
(
-
)
;
5.48
min
;
1458
(bp) ,
485
(aa)
|
|
Product
|
aminoacyl-histidine dipeptidase (peptidase D)
|
|
Operon Name
|
pepD
|
|
Note
|
GO_component: GO:0005737 - cytoplasm
|
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Function
|
enzyme; Degradation of proteins, peptides, glyco
|
|
Gene Ontology
|
GO:0005515
;
protein binding ( pepD )
GO:0005737
;
cytoplasm ( pepD )
GO:0006508
;
proteolysis ( pepD )
GO:0008233
;
peptidase activity ( pepD )
GO:0008237
;
metallopeptidase activity ( pepD )
GO:0008270
;
zinc ion binding ( pepD )
GO:0008769
;
X-His dipeptidase activity ( pepD )
GO:0016787
;
hydrolase activity ( pepD )
GO:0016805
;
dipeptidase activity ( pepD )
GO:0046872
;
metal ion binding ( pepD )
GO:0046983
;
protein dimerization activity ( pepD )
GO:0050897
;
cobalt ion binding ( pepD )
|
|
PID
|
1786432
|
EC number
(KEGG Pathway)
|
1.5.1.38
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
pepD
(
EG10695
)
|
|
Number of removed
|
1 aa cleaved
|
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SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
PEPD_ECOLI
(
P15288
)
|
|
- Protein name
|
Aminoacyl-histidine dipeptidase
|
|
- Synonyms
|
EC 3.4.13.3, Xaa-His dipeptidase, X-His dipeptidase, Beta-alanyl-histidine dipeptidase, Carnosinase, Peptidase D
|
|
- Gene name
|
Name=pepD; Synonyms=pepH; OrderedLocusNames=b0237;
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Homology Analysis
|
|
BLAST
|
|
Bacteria
|
|
GTOP
|
pepD
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Crystal Structure Of A Putative Peptidase T
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Aminoacyl-histidine dipeptidase
|
|
PSI-BLAST
|
Aminoacyl-histidine dipeptidase
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
aminoacyl-histidine dipeptidase (peptidase D) [Escherichia coli K12]
|
|
Pfam 28.0
(database updated :
2015-05
)
|
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Pfam
|
|
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PROSITE
|
|
PROSITE
|
ASN_GLYCOSYLATION
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
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MMBR References
|
Mol Gen Genet. 1989;215(3):369-73.
Accurate mapping of the Escherichia coli pepD gene by sequence analysis of its 5' flanking region.
Henrich B, Schroeder U, Frank RW, Plapp R.
(
2651887
)
|
J Bacteriol. 1991;173(23):7407-8.
Locations of the genes from pepD through proA on the physical map of the Escherichia coli chromosome.
Henrich B, Plapp R.
(
1938933
)
|
J Gen Microbiol. 1986;132(8):2337-43.
Cloning and expression of the pepD gene of Escherichia coli.
Klein J, Henrich B, Plapp R.
(
3540199
)
|
J Bacteriol. 1978;135(2):603-11.
Peptidase-deficient mutants of Escherichia coli.
Miller CG, Schwartz G.
(
355237
)
|
J Gen Microbiol. 1984;130(9):2253-65.
Transport and hydrolysis of antibacterial peptide analogues in Escherichia coli: backbone-modified aminoxy peptides.
Payne JW, Morley JS, Armitage P, Payne GM.
(
6389761
)
|
J Bacteriol. 1979;139(1):176-84.
Regulation of the biosynthesis of aminoacyl-transfer ribonucleic acid synthetases and of transfer ribonucleic acid in Escherichia coli. VI. Mutants with increased levels of glutaminyl-transfer ribonucleic acid synthetase and of glutamine transfer ribonucleic acid.
Cheung AY, Morgan S, Low KB, Soll D.
(
378954
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MSELSQLSPQ PLWDIFAKIC SIPHPSYHEE QLAEYIVGWA KEKGFHVERD QVGNILIRKP ATAGMENRKP
0071 VVLQAHLDMV PQKNNDTVHD FTKDPIQPYI DGEWVKARGT TLGADNGIGM ASALAVLADE NVVHGPLEVL
0141 LTMTEEAGMD GAFGLQGNWL QADILINTDS EEEGEIYMGC AGGIDFTSNL HLDREAVPAG FETFKLTLKG
0211 LKGGHSGGEI HVGLGNANKL LVRFLAGHAE ELDLRLIDFN GGTLRNAIPR EAFATIAVAA DKVDVLKSLV
0281 NTYQEILKNE LAEKEKNLAL LLDSVANDKA ALIAKSRDTF IRLLNATPNG VIRNSDVAKG VVETSLNVGV
0351 VTMTDNNVEI HCLIRSLIDS GKDYVVSMLD SLGKLAGAKT EAKGAYPGWQ PDANSPVMHL VRETYQRLFN
0421 KTPNIQIIHA GLECGLFKKP YPEMDMVSIG PTITGPHSPD EQVHIESVGH YWTLLTELLK EIPAK
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 ctcaaacata tctcgcaagc ctgtcttgtg
-070 ttgacaacat tttctgctaa ccctgtgacc tgcaatactg ttttgcgggt gatcgacaag gagacttaac
0001 gtgtctgaac tgtctcaatt atctccacag ccgctgtggg atatttttgc caaaatctgt tctattcctc
0071 acccgtccta tcatgaagag caactcgctg aatacattgt tggttgggca aaagagaaag gtttccatgt
0141 cgaacgcgat caggtaggta atatcctgat tcgtaaacct gctaccgcag gtatggaaaa tcgtaaaccg
0211 gtcgtcttac aggcccacct cgatatggtg ccgcagaaaa ataacgacac cgtgcatgac ttcacgaaag
0281 atcctatcca gccttatatt gatggcgaat gggttaaagc gcgcggcacc acgctgggtg cggataacgg
0351 cattggtatg gcctctgcgc tggcggttct ggctgacgaa aacgtggttc acggcccgct ggaagtgctg
0421 ctgaccatga ccgaagaagc cggtatggac ggtgcgttcg gcttacaggg caactggttg caggctgata
0491 ttctgattaa caccgactcc gaagaagaag gtgaaatcta catgggttgt gcggggggta tcgacttcac
0561 ctccaacctg catttagatc gtgaagcggt tccagctggt tttgaaacct tcaagttaac cttaaaaggt
0631 ctgaaaggcg gtcactccgg cggggaaatc cacgttgggc tgggtaatgc caacaaactg ctggtgcgct
0701 tcctggcggg tcatgcggaa gaactggatc tgcgccttat cgatttcaac ggcggcacac tgcgtaacgc
0771 catcccgcgt gaagcctttg cgaccattgc tgtcgcagct gataaagtcg acgtcctgaa atctctggtg
0841 aatacctatc aggagatcct gaaaaacgag ctggcagaaa aagagaaaaa tctggccttg ttgctggact
0911 ctgtagcgaa cgataaagct gccctgattg cgaaatctcg cgataccttt attcgtctgc tgaacgccac
0981 cccgaacggt gtgattcgta actccgatgt agccaaaggt gtggttgaaa cctccctgaa cgtcggtgtg
1051 gtgaccatga ctgacaataa cgtagaaatt cactgcctga tccgttcact gatcgacagc ggtaaagact
1121 acgtggtgag catgctggat tcgctgggta aactggctgg cgcgaaaacc gaagcgaaag gcgcatatcc
1191 tggctggcag ccggacgcta attctccggt gatgcatctg gtacgtgaaa cctatcagcg cctgttcaac
1261 aagacgccga acatccagat tatccacgcg ggcctggaat gtggtctgtt caaaaaaccg tatccggaaa
1331 tggacatggt ttctatcggg ccaactatca ccggtccaca ctctccggat gagcaagttc acatcgaaag
1401 cgtaggtcat tactggacac tgctgactga actgctgaaa gaaattccgg cgaagtaatt atttgatttg
1471 ctgccggatg gcgtttaatc gccttccggc agtttcatcc ttcattatcc ttcgataaaa gccatccctg
1541 taaatgtccg tcgcgggt
|
