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PEC Original Annotations
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Essentiality
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Class
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essential
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References (PMID)
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J Bacteriol. 1992;174(2):508-13.
Overproduction of beta-ketoacyl-acyl carrier protein synthase I imparts thiolactomycin resistance to Escherichia coli K-12.
Tsay JT, Rock CO, Jackowski S.
(
1729241
)
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Deletion
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OCL64
(D)
,
OCL64-7
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
fabB
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Related strains
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Strains Search
|
Search strains by gene name:
fabB
Search strains by all related name:
fabB b2323 ECK2317 fabC JW2320
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General information (Go to Linear View: )
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Gene Name
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fabB
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Alternative name
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b2323,ECK2317,fabC,JW2320
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Location, Length
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2,438,407 - 2,439,627
(
-
)
;
52.56
min
;
1221
(bp) ,
406
(aa)
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Product
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3-oxoacyl-[acyl-carrier-protein] synthase I
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Operon Name
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fabB
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Note
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GO_component: GO:0005737 - cytoplasm
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Function
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enzyme; Fatty acid and phosphatidic acid biosynthesis
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Gene Ontology
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GO:0003824
;
catalytic activity ( fabB )
GO:0004315
;
3-oxoacyl-[acyl-carrier-protein] synthase activity ( fabB )
GO:0005737
;
cytoplasm ( fabB )
GO:0006633
;
fatty acid biosynthetic process ( fabB )
GO:0008152
;
metabolic process ( fabB )
GO:0008415
;
acyltransferase activity ( fabB )
GO:0008610
;
lipid biosynthetic process ( fabB )
GO:0009058
;
biosynthetic process ( fabB )
GO:0016740
;
transferase activity ( fabB )
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PID
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1788663
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EC number
(KEGG Pathway)
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2.3.1.41
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Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
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EcoGene
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fabB
(
EG10274
)
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Number of removed
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0 aa cleaved
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SWISS-PROT
(
Show details
[
1
more]
)
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Entry name(Acc.no)
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FABB_ECOLI
(
P14926
;
Q9R828; Q9R829; Q9R830
)
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- Protein name
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3-oxoacyl-[acyl-carrier-protein] synthase I
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- Synonyms
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EC 2.3.1.41, Beta- ketoacyl-ACP synthase I, KAS I
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- Gene name
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Name=fabB; Synonyms=fabC; OrderedLocusNames=b2323, c2869;
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MMBR References
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J Biol Chem. 1980;255:3263-3265
β-Ketoacyl-acyl carrier protein synthase II of Escherichia coli. Evidence for function in the thermal regulation of fatty acid synthesis.
Garwin, J. L., A. L. Klages, and J. E. Cronan, Jr.
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J Biol Chem. 1980;255:11949-11956
Structural, enzymatic, and genetic studies of beta-ketoacylacyl carrier protein synthases I and II of Escherichia coli.
Garwin, J. L., A. L. Klages, and J. E. Cronan, Jr.
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Carlsberg Res Commun. 1988;53(6):371-9.
Role of Escherichia coli beta-ketoacyl-ACP synthase I in unsaturated fatty acid synthesis.
Siggaard-Andersen M.
(
3076377
)
|
| Sequences |
Amino acid
FASTA format
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0001 MKRAVITGLG IVSSIGNNQQ EVLASLREGR SGITFSQELK DSGMRSHVWG NVKLDTTGLI DRKVVRFMSD
0071 ASIYAFLSME QAIADAGLSP EAYQNNPRVG LIAGSGGGSP RFQVFGADAM RGPRGLKAVG PYVVTKAMAS
0141 GVSACLATPF KIHGVNYSIS SACATSAHCI GNAVEQIQLG KQDIVFAGGG EELCWEMACE FDAMGALSTK
0211 YNDTPEKASR TYDAHRDGFV IAGGGGMVVV EELEHALARG AHIYAEIVGY GATSDGADMV APSGEGAVRC
0281 MKMAMHGVDT PIDYLNSHGT STPVGDVKEL AAIREVFGDK SPAISATKAM TGHSLGAAGV QEAIYSLLML
0351 EHGFIAPSIN IEELDEQAAG LNIVTETTDR ELTTVMSNSF GFGGTNATLV MRKLKD
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 aaatttctct attaaatggc tgatcggact
-070 tgttcggcgt acaagtgtac gctattgtgc attcgaaact tactctatgt gcgacttaca gaggtattga
0001 atgaaacgtg cagtgattac tggcctgggc attgtttcca gcatcggtaa taaccagcag gaagtcctgg
0071 catctctgcg tgaaggacgt tcagggatca ctttctctca ggagctgaag gattccggca tgcgtagcca
0141 cgtctggggc aacgtaaaac tggataccac tggcctcatt gaccgcaaag ttgtgcgctt tatgagcgac
0211 gcatccattt atgcattcct ttctatggag caggcaatcg ctgatgcggg cctctctccg gaagcttacc
0281 agaataaccc gcgcgttggc ctgattgcag gttccggcgg cggctccccg cgtttccagg tgttcggcgc
0351 tgacgcaatg cgcggcccgc gcggcctgaa agcggttggc ccgtatgtgg tcaccaaagc gatggcatcc
0421 ggcgtttctg cctgcctcgc caccccgttt aaaattcatg gcgttaacta ctccatcagc tccgcgtgtg
0491 cgacttccgc acactgtatc ggtaacgcag tagagcagat ccaactgggc aaacaggaca tcgtgtttgc
0561 tggcggcggc gaagagctgt gctgggaaat ggcttgcgaa ttcgacgcaa tgggtgcgct gtctactaaa
0631 tacaacgaca ccccggaaaa agcctcccgt acttacgacg ctcaccgtga cggtttcgtt atcgctggcg
0701 gcggcggtat ggtagtggtt gaagagctgg aacacgcgct ggcgcgtggt gctcacatct atgctgaaat
0771 cgttggctac ggcgcaacct ctgatggtgc agacatggtt gctccgtctg gcgaaggcgc agtacgctgc
0841 atgaagatgg cgatgcatgg cgttgatacc ccaatcgatt acctgaactc ccacggtact tcgactccgg
0911 ttggcgacgt gaaagagctg gcagctatcc gtgaagtgtt cggcgataag agcccggcga tttctgcaac
0981 caaagccatg accggtcact ctctgggcgc tgctggcgta caggaagcta tctactctct gctgatgctg
1051 gaacacggct ttatcgcccc gagcatcaac attgaagagc tggacgagca ggctgcgggt ctgaacatcg
1121 tgaccgaaac gaccgatcgc gaactgacca ccgttatgtc taacagcttc ggcttcggcg gcaccaacgc
1191 cacgctggta atgcgcaagc tgaaagatta attcgcagta ggtcggagta gacgcgccag cgtcgcatcc
1261 gacgttacgc gccaatgcgg cctccggcac taacgcaaaa gggaacctga tggttccctt t
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