MG1655
W3110
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Gene Report : hisJ
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
     Deletion OCL64 (D)  ,  OCL64-3 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  hisJ
Related strains
     Strains Search Search strains by gene name:  hisJ   Search strains by all related name:  hisJ b2309 ECK2303 JW2306

General information  (Go to Linear View:)
 Gene Name hisJ  
 Alternative name b2309,ECK2303,JW2306  
 Location, Length 2,424,028 - 2,424,810 (  -  ) ;   52.25 min ; 783 (bp) ,   260 (aa) Go to Linear View
 Product histidine/lysine/arginine/ornithine transporter subunit  
 Operon Name argT-hisJQMP  
 Note histidine-binding periplasmic protein of high-affinity histidine transport system; periplasmic-binding component of ABC superfamily; GO_component: GO:0042597 - periplasmic space; GO_process: GO:0000105 - histidine biosynthetic process  
 Function transport; Transport of small molecules: Amino acids, amines  
 Gene Ontology GO:0005215; transporter activity ( hisJ )
GO:0006810; transport ( hisJ )
GO:0006865; amino acid transport ( hisJ )
GO:0030288; outer membrane-bounded periplasmic space ( hisJ )
GO:0042597; periplasmic space ( hisJ )
 PID 1788648  
 EC number
  (KEGG Pathway)
 
 
Verified Protein Starts (data compiled from literature and appropriate citations are available from EcoGene)
     EcoGene hisJ ( EG12124 )  
    Number of removed 22 aa cleaved  
SWISS-PROT  ( Show details )
  botton Entry name(Acc.no) HISJ_ECOLI ( P39182 ; P77763 )
    -  Protein name Histidine-binding periplasmic protein precursor  
    -  Synonyms HBP  
    -  Gene name Name=hisJ; OrderedLocusNames=b2309, c2851, z3571, ECs3193;  

 Linear View (Whole Mode)
View Location
   2415.0  –  2440.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP hisJ (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Histidine-Binding Protein Complexed With L-Histidine  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Histidine-binding periplasmic protein precursor (HBP)  
         PSI-BLAST Lysine-arginine-ornithine-binding periplasmic protein precursor
    nr     (database updated : 2007.02.20 )
         BLAST histidine-binding periplasmic protein of high-affinity histidine transport system [Escherichia coli O157:H7 EDL933]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    TYR_PHOSPHO_SITE    MYRISTYL    AMIDATION    SBP_BACTERIAL_3     

Other Cross-Reference
    COG COG0834ET 
    EcoCyc hisJ 

MMBR References
J. Supramol. Struct. (Suppl.) 1980;13:117-130.
Cloning of the histidine transport genes from Salmonella typhimurium and characterization of an analogous transport system in Escherichia coli.
Ardeshir, F., and G. F.-L. Ames.
J Bacteriol. 1980;143(2):1081-5.
Isolation and Characterization of acetate kinase and phosphotransacetylase mutants of Escherichia coli and Salmonella typhimurium.
LeVine SM, Ardeshir F, Ames GF. ( 6259116 )

Sequences
Amino acid
FASTA format
0001 MKKLVLSLSL VLAFSSATAA FAAIPQNIRI GTDPTYAPFE SKNSQGELVG FDIDLAKELC KRINTQCTFV 
0071 ENPLDALIPS LKAKKIDAIM SSLSITEKRQ QEIAFTDKLY AADSRLVVAK NSDIQPTVES LKGKRVGVLQ 
0141 GTTQETFGNE HWAPKGIEIV SYQGQDNIYS DLTAGRIDAA FQDEVAASEG FLKQPVGKDY KFGGPSVKDE 
0211 KLFGVGTGMG LRKEDNELRE ALNKAFAEMR ADGTYEKLAK KYFDFDVYGG 

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             acggggcggg atattttgcc ttgatggtca 
-070 attttatggc acgataagtg taacaaacct gtaaatattc cctataaaaa gactgtcagt tgaggacatt 
0001 atgaaaaaac tggtgctatc gctctctctg gttctggcct tctccagcgc aactgcggcg tttgctgcga 
0071 ttccgcaaaa catccgcatc ggtaccgacc cgacctatgc gccatttgaa tcaaaaaatt cacaaggcga 
0141 actggttggc ttcgatatcg atctggcaaa ggaattatgc aaacgcatca atacgcaatg tacgtttgtc 
0211 gaaaatccgc tggatgcgtt aatcccgtcc ttaaaagcga agaagattga cgccatcatg tcatcgcttt 
0281 ccattacgga aaaacgtcag caagaaatag ccttcaccga caaactgtac gctgccgatt ctcgtttggt 
0351 ggtggcgaaa aattctgaca ttcagccgac agtcgagtcg ctgaaaggca aacgggtagg cgtattgcag 
0421 ggcaccaccc aggagacgtt cggtaatgaa cattgggcac caaaaggcat tgaaatcgtc tcgtatcagg 
0491 ggcaggacaa catttattct gacctgactg ccggacgtat tgatgccgcg ttccaggatg aggtcgctgc 
0561 cagcgaaggt ttcctcaaac aacctgtcgg taaagattac aaattcggtg gcccgtctgt taaagatgaa 
0631 aaactgtttg gcgtagggac cggcatgggc ctgcgtaaag aagataacga actgcgcgaa gcactgaaca 
0701 aagcctttgc cgaaatgcgc gctgacggta cttacgagaa attagcgaaa aagtacttcg attttgatgt 
0771 ttatggtggc taatcgccat cggtgaaaga aagcccgctc ccttcgggta accggaggga gacaagaggc 
0841 ggtaattcac cacacacgac aggacaggca gcatgttgta tgg