MG1655
W3110
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Gene Report : hisM
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Mol Microbiol. 1991;5(6):1375-83.
A chimeric nucleotide-binding protein, encoded by a hisP-malK hybrid gene, is functional in maltose transport in Salmonella typhimurium.
Schneider E, Walter C. ( 1787792 )
     Deletion OCL64 (D)  ,  OCL64-3 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  hisM
Related strains
     Strains Search Search strains by gene name:  hisM   Search strains by all related name:  hisM b2307 ECK2301 f238 JW2304

General information  (Go to Linear View:)
 Gene Name hisM  
 Alternative name b2307,ECK2301,f238,JW2304  
 Location, Length 2,422,539 - 2,423,255 (  -  ) ;   52.21 min ; 717 (bp) ,   238 (aa) Go to Linear View
 Product histidine/lysine/arginine/ornithine transporter subunit  
 Operon Name argT-hisJQMP  
 Note histidine transport, membrane protein M; membrane component of ABC superfamily; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0009089 - lysine biosynthetic process via diaminopimelate; GO_process: GO:0006526 - arginine biosynthetic process  
 Function transport; Transport of small molecules: Amino acids, amines  
 Gene Ontology GO:0005215; transporter activity ( hisM )
GO:0005886; plasma membrane ( hisM )
GO:0006810; transport ( hisM )
GO:0006865; amino acid transport ( hisM )
GO:0009276; 1-2nm peptidoglycan-based cell wall ( hisM )
GO:0016020; membrane ( hisM )
GO:0016021; integral to membrane ( hisM )
 PID 1788645  
 EC number
  (KEGG Pathway)
 
 
SWISS-PROT  ( Show details )
  botton Entry name(Acc.no) HISM_ECOLI ( P20091 ; P76936 )
    -  Protein name Histidine transport system permease protein hisM.  
    -  Synonyms  
    -  Gene name OrderedLocusNames=b2307, c2849, z3569, ECs3191, SF2383, S2518;  

 Linear View (Whole Mode)
View Location
   2410.0  –  2435.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP hisM (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
        PSI-BLAST  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Histidine transport system permease protein hisM  
         PSI-BLAST Histidine transport system permease protein hisM
    nr     (database updated : 2007.02.20 )
         BLAST histidine transport system membrane protein M [Escherichia coli O157:H7 str. Sakai]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    BPD_TRANSP_INN_MEMBR     

Other Cross-Reference
    COG COG4160E 
    EcoCyc hisM 

MMBR References
Nucleic Acids Res. 1987;15(20):8568
Sequence of the complete P protein gene and part of the M protein gene from the histidine transport operon of Escherichia coli compared to that of Salmonella typhimurium.
Kraft R, Leinwand LA. ( 3313284 )

Sequences
Amino acid
FASTA format
0001 MIEILHEYWK PLLWTDGYRF TGVAITLWLL ILSVVIGGVL ALFLAIGRVS SNKYIQFPIW LFTYIFRGTP 
0071 LYVQLLVFYS GMYTLEIVKG TEFLNAFFRS GLNCTVLALT LNTCAYTTEI FAGAIRSVPH GEIEAARAYG 
0141 FSTFKMYRCI ILPSALRIAL PAYSNEVILM LHSTALAFTA TVPDLLKIAR DINAATYQPF TAFGIAAVLY 
0211 LIISYVLISL FRRAEKRWLQ HVKPSSTH

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             tcgtctgtgg cgtgatttac ctggttttca 
-070 ccactgtttc caatggtgtg ctgctgttcc ttgagcgccg ctactccgtg ggtgtgaaga gggctgacct 
0001 gtgatcgaaa tcttacatga atactggaaa ccgctgctgt ggaccgacgg ttatcgcttt actggtgtgg 
0071 cgatcactct gtggctgctt attttgtcgg tagtgatagg cggagtcctg gcgctgtttc tggcgattgg 
0141 tcgtgtctcc agtaataaat acatccagtt tccaatctgg ttatttacct atatttttcg cggtacgccg 
0211 ctgtatgttc agttgctggt gttctattcc ggcatgtaca cgcttgagat tgttaaggga accgaattcc 
0281 ttaacgcttt cttccgcagt ggcctgaact gtaccgtgct ggcgctgacg cttaacacct gcgcttacac 
0351 taccgagatt tttgctgggg caatccgttc ggttccgcat ggggaaattg aagccgccag agcctatggc 
0421 ttctcgactt ttaaaatgta tcgctgcatt attttgcctt ctgcgctgcg tattgcgtta ccggcataca 
0491 gcaacgaagt gatcctgatg ctgcactcta ctgcgttggc atttactgcc acggtgccgg atctgctgaa 
0561 aatagcccgc gatattaacg ccgccacgta tcaacctttt accgccttcg gcattgccgc ggtgctctat 
0631 ttaatcatct cttatgtcct gatcagcctc tttcgcagag cggaaaaacg ctggttgcag catgtgaaac 
0701 cttcttcaac gcactgagaa tacgatgtcc gagaataaat taaacgttat cgatttgcac aaacgctacg 
0771 gcgaacatga agtgctgaaa ggggtatcac tgcaagcgaa tgccgga