MG1655
W3110
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Gene Report : hisP
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
J Bacteriol. 1980;143(2):1081-5.
Isolation and Characterization of acetate kinase and phosphotransacetylase mutants of Escherichia coli and Salmonella typhimurium.
LeVine SM, Ardeshir F, Ames GF. ( 6259116 )
     Deletion OCL64 (D)  ,  OCL64-3 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  hisP
Related strains
     Strains Search Search strains by gene name:  hisP   Search strains by all related name:  hisP b2306 ECK2300 JW2303

General information  (Go to Linear View:)
 Gene Name hisP  
 Alternative name b2306,ECK2300,JW2303  
 Location, Length 2,421,758 - 2,422,531 (  -  ) ;   52.20 min ; 774 (bp) ,   257 (aa) Go to Linear View
 Product histidine/lysine/arginine/ornithine transporter subunit  
 Operon Name argT-hisJQMP  
 Note ATP-binding component of histidine transport; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0009089 - lysine biosynthetic process via diaminopimelate; GO_process: GO:0006526 - arginine biosynthetic process; GO_process: GO:0000105 - histidine biosynthetic process; GO_process: GO:0009063 - cellular amino acid catabolic process  
 Function transport; Transport of small molecules: Amino acids, amines  
 Gene Ontology GO:0000166; nucleotide binding ( hisP )
GO:0005515; protein binding ( hisP )
GO:0005524; ATP binding ( hisP )
GO:0005886; plasma membrane ( hisP )
GO:0006810; transport ( hisP )
GO:0006865; amino acid transport ( hisP )
GO:0016020; membrane ( hisP )
GO:0016887; ATPase activity ( hisP )
GO:0017111; nucleoside-triphosphatase activity ( hisP )
 PID 1788644  
 EC number
  (KEGG Pathway)
 
 
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) HISP_ECOLI ( P07109 ; P77299 )
    -  Protein name Histidine transport ATP-binding protein hisP.  
    -  Synonyms  
    -  Gene name Name=hisP; OrderedLocusNames=b2306;  

 Linear View (Whole Mode)
View Location
   2410.0  –  2435.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP hisP (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Atp-Binding Subunit Of The Histidine Permease From Salmonella Typhimurium  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Histidine transport ATP-binding protein hisP  
         PSI-BLAST Phosphate import ATP-binding protein pstB
    nr     (database updated : 2007.02.20 )
         BLAST histidine/lysine/arginine/ornithine transporter subunit [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE GLYCOSAMINOGLYCAN    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    ATP_GTP_A    ABC_TRANSPORTER     

Other Cross-Reference
    COG COG4598E 
    EcoCyc hisP 

MMBR References
J. Supramol. Struct. (Suppl.) 1980;13:117-130.
Cloning of the histidine transport genes from Salmonella typhimurium and characterization of an analogous transport system in Escherichia coli.
Ardeshir, F., and G. F.-L. Ames.
Nucleic Acids Res. 1987;15(20):8568
Sequence of the complete P protein gene and part of the M protein gene from the histidine transport operon of Escherichia coli compared to that of Salmonella typhimurium.
Kraft R, Leinwand LA. ( 3313284 )
J Bacteriol. 1980;143(2):1081-5.
Isolation and Characterization of acetate kinase and phosphotransacetylase mutants of Escherichia coli and Salmonella typhimurium.
LeVine SM, Ardeshir F, Ames GF. ( 6259116 )

Sequences
Amino acid
FASTA format
0001 MSENKLNVID LHKRYGEHEV LKGVSLQANA GDVISIIGSS GSGKSTFLRC INFLEKPSEG SIVVNGQTIN 
0071 LVRDKDGQLK VADKNQLRLL RTRLTMVFQH FNLWSHMTVL ENVMEAPIQV LGLSKQEARE RAVKYLAKVG 
0141 IDERAQGKYP VHLSGGQQQR VSIARALAME PEVLLFDEPT SALDPELVGE VLRIMQQLAE EGKTMVVVTH 
0211 EMGFARHVST HVIFLHQGKI EEEGAPEQLF GNPQSPRLQR FLKGSLK

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             ctctatttaa tcatctctta tgtcctgatc 
-070 agcctctttc gcagagcgga aaaacgctgg ttgcagcatg tgaaaccttc ttcaacgcac tgagaatacg 
0001 atgtccgaga ataaattaaa cgttatcgat ttgcacaaac gctacggcga acatgaagtg ctgaaagggg 
0071 tatcactgca agcgaatgcc ggagatgtaa taagcatcat cggatcgtcg ggatcgggga aaagtacctt 
0141 tctgcgctgc attaacttcc tcgaaaaacc gagtgaaggg tcgatcgtgg tcaatggcca gacgatcaat 
0211 ctggtgcgcg acaaagacgg tcaactcaaa gtcgccgata aaaatcaact gcgcttactg cgcacacgcc 
0281 tgacgatggt attccagcac ttcaatctct ggagccatat gacggtgctg gaaaacgtca tggaagcgcc 
0351 gattcaggtg ttgggcctga gcaagcagga agcgcgcgag cgggcggtga agtatctggc aaaagtcggg 
0421 atagacgaac gtgcgcaggg gaaatatccg gtgcatcttt ccggcggtca gcaacagcgt gtttctatcg 
0491 cgcgggcgct ggcgatggaa ccggaagttt tactgtttga tgaacctacc tcggcgctcg atcctgaact 
0561 ggtaggcgaa gtgttgcgta ttatgcagca actggcagaa gaggggaaaa ccatggtggt agtgactcac 
0631 gaaatgggct ttgctcgcca tgtttctact catgtcattt tcctccatca ggggaaaata gaagaagagg 
0701 gcgcgccgga gcagttattt ggcaacccgc aaagccctcg tctgcaacgg ttccttaagg gatcgctgaa 
0771 ataatttcct ctccggtggc taacgctgcc ggagtatttt catggggaat ttgcgagtca gcttccgctg 
0841 aaatgtaaaa gttacagtcc gctaaaaata cttc