MG1655
W3110
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Gene Report : fruA
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Mol Gen Genet. 1986;203(3):435-44.
Relationship between pseudo-HPr and the PEP: fructose phosphotransferase system in Salmonella typhimurium and Escherichia coli.
Geerse RH, Ruig CR, Schuitema AR, Postma PW. ( 3528748 )
     Deletion OCL73-1 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  fruA
Related strains
     Strains Search Search strains by gene name:  fruA   Search strains by all related name:  fruA b2167 ECK2160 JW2154 ptsF

General information  (Go to Linear View:)
 Gene Name fruA  
 Alternative name b2167,ECK2160,JW2154,ptsF  
 Location, Length 2,257,741 - 2,259,432 (  -  ) ;   48.66 min ; 1692 (bp) ,   563 (aa) Go to Linear View
 Product fused fructose-specific PTS enzymes:IIBcomponent/IIC components  
 Operon Name fruBKA  
 Note PTS system, fructose-specific transport protein; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0016052 - carbohydrate catabolic process  
 Function regulator; Degradation of small molecules: Carbon compounds  
 Gene Ontology GO:0005351; sugar:hydrogen ion symporter activity ( fruA )
GO:0005886; plasma membrane ( fruA )
GO:0006810; transport ( fruA )
GO:0008643; carbohydrate transport ( fruA )
GO:0008982; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity ( fruA )
GO:0009401; phosphoenolpyruvate-dependent sugar phosphotransferase system ( fruA )
GO:0016020; membrane ( fruA )
GO:0016021; integral to membrane ( fruA )
GO:0016301; kinase activity ( fruA )
GO:0016740; transferase activity ( fruA )
 PID 1788492  
 EC number
  (KEGG Pathway)
 
 
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) PTFB_ECOLI ( P20966 )
    -  Protein name PTS system, fructose-specific IIBC component  
    -  Synonyms EIIBC-Fru, Fructose- permease IIBC component, Phosphotransferase enzyme II, BC component, EC 2.7.1.69, EII-Fru  
    -  Gene name Name=fruA; Synonyms=ptsF; OrderedLocusNames=b2167;  

 Linear View (Whole Mode)
View Location
   2245.0  –  2270.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP fruA (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
        PSI-BLAST  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST PTS system fructose-specific EIIBC component  
         PSI-BLAST PTS system fructose-specific EIIBC component
    nr     (database updated : 2007.02.20 )
         BLAST fused fructose-specific PTS enzymes: IIBcomponent/IIC components [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    CAMP_PHOSPHO_SITE    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    TYR_PHOSPHO_SITE    MYRISTYL    LEUCINE_ZIPPER    PTS_EIIA_2     

Other Cross-Reference
    COG COG1299G 
    EcoCyc fruA 

MMBR References
Mol Gen Genet. 1986;203(3):435-44.
Relationship between pseudo-HPr and the PEP: fructose phosphotransferase system in Salmonella typhimurium and Escherichia coli.
Geerse RH, Ruig CR, Schuitema AR, Postma PW. ( 3528748 )
J Gen Microbiol. 1988;134(10):2757-68.
Nucleotide sequence of fruA, the gene specifying enzyme IIfru of the phosphoenolpyruvate-dependent sugar phosphotransferase system in Escherichia coli K12.
Prior TI, Kornberg HL. ( 3076173 )

Sequences
Amino acid
FASTA format
0001 MKTLLIIDAN LGQARAYMAK TLLGAAARKA KLEIIDNPND AEMAIVLGDS IPNDSALNGK NVWLGDISRA 
0071 VAHPELFLSE AKGHAKPYTA PVAATAPVAA SGPKRVVAVT ACPTGVAHTF MAAEAIETEA KKRGWWVKVE 
0141 TRGSVGAGNA ITPEEVAAAD LVIVAADIEV DLAKFAGKPM YRTSTGLALK KTAQELDKAV AEATPYEPAG 
0211 KAQTATTESK KESAGAYRHL LTGVSYMLPM VVAGGLCIAL SFAFGIEAFK EPGTLAAALM QIGGGSAFAL 
0281 MVPVLAGYIA FSIADRPGLT PGLIGGMLAV STGSGFIGGI IAGFLAGYIA KLISTQLKLP QSMEALKPIL 
0351 IIPLISSLVV GLAMIYLIGK PVAGILEGLT HWLQTMGTAN AVLLGAILGG MMCTDMGGPV NKAAYAFGVG 
0421 LLSTQTYGPM AAIMAAGMVP PLAMGLATMV ARRKFDKAQQ EGGKAALVLG LCFISEGAIP FAARDPMRVL 
0491 PCCIVGGALT GAISMAIGAK LMAPHGGLFV LLIPGAITPV LGYLVAIIAG TLVAGLAYAF LKRPEVDAVA 
0561 KAA

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             gtaagtcaaa gcaatgtggg tattaccgat 
-070 cgtccgcagt tggccgcaat gatggcgcgc gtcgacttac aaccttttaa ctgacagcag gagaggcata 
0001 atgaaaacgc tgctgattat tgacgctaat ctcggtcagg cacgcgccta tatggcgaag accctgctgg 
0071 gcgcggcggc gcgaaaagca aaactggaaa tcatcgacaa tccgaacgac gctgaaatgg cgattgttct 
0141 cggtgattcc atcccgaacg acagcgcgct gaacggtaaa aatgtctggc tgggcgatat ttcccgggca 
0211 gttgcgcacc ctgagctgtt cctgagtgaa gccaaaggcc atgcgaaacc ttacactgcg ccggtcgctg 
0281 cgacagcacc agttgccgcc agcggtccga aacgcgtagt tgcggtgact gcttgcccga ctggcgtagc 
0351 acacaccttt atggcggctg aagccattga aaccgaagcg aaaaaacgtg gctggtgggt gaaagttgaa 
0421 acccgtggtt ctgttggcgc gggtaatgca atcactcccg aagaagtcgc agcagcggat ctggtgattg 
0491 tggcggcaga tatcgaagtg gatctggcga aatttgctgg taaaccgatg tatcgtacct ctaccggtct 
0561 ggcgctgaag aaaaccgcgc aggaactgga taaagcggtt gctgaagcaa cgccgtatga accggcgggc 
0631 aaagctcaaa cggcgaccac tgaaagtaag aaagagagtg caggcgcata ccgtcacttg ctgacgggcg 
0701 tttcttacat gctgccgatg gtcgttgcag gtggtctgtg tatcgcgctt tcttttgctt ttggtatcga 
0771 agcgtttaaa gagccgggta cgttggctgc ggcgctgatg cagattggtg gtggttcagc ctttgcgctg 
0841 atggtgccgg tactggcagg ttatattgcc ttttccattg ccgatcgtcc gggcctcact ccgggtctga 
0911 ttggcggtat gctggcggtc agcaccggtt ctggcttcat tggtggtatt attgcgggct tcctggctgg 
0981 ttacattgcg aagttaatca gtacgcaatt gaaactgcca cagagtatgg aggcgctgaa accgatcctg 
1051 atcattccgc taatttccag tctggtggtc ggtctggcga tgatctacct gatcggtaaa ccagttgctg 
1121 gcattctcga agggctgact cactggctgc agaccatggg gactgcgaat gcggttctgc tgggggcgat 
1191 cctcggtggc atgatgtgta ctgacatggg cggtccggta aacaaagcag cgtacgcatt cggtgtgggt 
1261 ctgctgagta ctcaaaccta tggcccgatg gcggcgatta tggcggcagg tatggtgcca ccgctggcaa 
1331 tgggtctggc aacaatggtg gcgcgtcgca aattcgacaa agcgcagcag gaaggtggca aagccgctct 
1401 ggtattggga ctgtgcttca tttcggaagg tgcaattccg tttgctgctc gtgatccgat gcgtgtgctg 
1471 ccgtgctgta tcgtgggtgg ggcgctgact ggcgcaatct caatggcgat tggtgcgaaa ctgatggcac 
1541 cgcacggtgg tctgtttgtt ctgctgatcc ctggcgctat tacgccggta ttgggttacc tggtagcaat 
1611 tattgccggt acgctggtgg cgggtttggc ctatgccttc ctgaaacgtc cggaagtgga cgcagtagcg 
1681 aaagcagcgt aataaaaggt gtgttacagg gcagaaattt cctgtcctgt aacatttgat gagcgcaaag 
1751 agaatgaccg gtttgtgaat gtaattttat gaatttaaat gg