MG1655
W3110
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Gene Report : mglC
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)  
     Deletion 16-2 (ND) (LD)  ,  OCL74 (D)  ,  OCL74-4 (LD 16-2_CRS) (D)  ,  OCL74-5 (LD 16-2_P/O) (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  mglC
Related strains
     Strains Search Search strains by gene name:  mglC   Search strains by all related name:  mglC b2148 ECK2141 JW2135 mglP

General information  (Go to Linear View:)
 Gene Name mglC  
 Alternative name b2148,ECK2141,JW2135,mglP  
 Location, Length 2,234,765 - 2,235,775 (  -  ) ;   48.17 min ; 1011 (bp) ,   336 (aa) Go to Linear View
 Product methyl-galactoside transporter subunit  
 Operon Name mglBAC  
 Note methyl-galactoside transport and galactose taxis; membrane component of ABC superfamily; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0016052 - carbohydrate catabolic process  
 Function transport; Transport of small molecules: Carbohydrates, organic acids, alcohols  
 Gene Ontology GO:0005215 ; transporter activity ( mglC )
GO:0005351 ; sugar:hydrogen ion symporter activity ( mglC )
GO:0005886 ; plasma membrane ( mglC )
GO:0006810 ; transport ( mglC )
GO:0008643 ; carbohydrate transport ( mglC )
GO:0016020 ; membrane ( mglC )
GO:0016021 ; integral to membrane ( mglC )
 PID 1788471  
 EC number
  (KEGG Pathway)
 
 
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) MGLC_ECOLI ( P23200 )
    -  Protein name Galactoside transport system permease protein mglC.  
    -  Synonyms  
    -  Gene name Name=mglC; OrderedLocusNames=b2148;  

 Linear View (Whole Mode)
View Location
   2225.0  –  2250.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP mglC (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
        PSI-BLAST  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Galactoside transport system permease protein mglC  
         PSI-BLAST Galactoside transport system permease protein mglC
    nr     (database updated : 2007.02.20 )
         BLAST beta-methylgalactoside transporter inner membrane component [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL     

Other Cross-Reference
    COG COG4211G 
    EcoCyc mglC 

MMBR References
J Bacteriol. 1965;90(4):946-57.
Positive control of enzyme synthesis by gene C in the L-arabinose system.
Englesberg E, Irr J, Power J, Lee N. ( 5321403 )
J Bacteriol. 1983;153(1):408-15.
Characterization of the mgl operon of Escherichia coli by transposon mutagenesis and molecular cloning.
Harayama S, Bollinger J, Iino T, Hazelbauer GL. ( 6294056 )
Mol Gen Genet. 1991;229(3):453-9.
Nucleotide sequence and analysis of the mgl operon of Escherichia coli K12.
Hogg RW, Voelker C, Von Carlowitz I. ( 1719366 )
Mol Gen Genet. 1984;197(1):175-81.
Mapping of markers in the gyrA-his region of Escherichia coli.
Middendorf A, Schweizer H, Vreemann J, Boos W. ( 6392823 )
J Bacteriol. 1976;126(2):999-1001.
Altered deoxyribonucleotide pools in P2 eductants of Escherichia coli K-12 due to deletion of the dcd gene.
Neuhard J, Thomassen E. ( 177407 )
J Bacteriol. 1974;117(2):509-16.
Isolation and complementation of mutants in galactose taxis and transport.
Ordal GW, Adler J. ( 4359647 )
J Biol Chem. 1982;257:9030-9034
Identification of the mglA gene product in the beta-methylgalactoside transport system of Escherichia coli using plasmid DNA deletions generated in vitro.
Rotman, B., and R. Guzman.
J Bacteriol. 1981;147(3):920-4.
High-affinity arabinose transport mutants of Escherichia coli: isolation and gene location.
Clark AF, Hogg RW. ( 7024251 )

Sequences
Amino acid
FASTA format
0001 MSALNKKSFL TYLKEGGIYV VLLVLLAIII FQDPTFLSLL NLSNILTQSS VRIIIALGVA GLIVTQGTDL 
0071 SAGRQVGLAA VVAATLLQSM DNANKVFPEM ATMPIALVIL IVCAIGAVIG LINGLIIAYL NVTPFITTLG 
0141 TMIIVYGINS LYYDFVGASP ISGFDSGFST FAQGFVALGS FRLSYITFYA LIAVAFVWVL WNKTRFGKNI 
0211 FAIGGNPEAA KVSGVNVGLN LLMIYALSGV FYAFGGMLEA GRIGSATNNL GFMYELDAIA ACVVGGVSFS 
0281 GGVGTVIGVV TGVIIFTVIN YGLTYIGVNP YWQYIIKGAI IIFAVALDSL KYARKK

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             gagcaatggt ctcgtttccg gaattgtcga 
-070 tacaaaaaca acaacgcaaa acgaaattct gcgtcttgcg tctttgcacc tttaagatta ggggcttccc 
0001 atgagtgcgt taaataagaa aagttttctt acttacctga aagagggcgg tatttacgtc gttcttttag 
0071 ttttgctggc gattattatt ttccaggacc caacattttt aagtctgttg aacttaagta atattctcac 
0141 ccagtcatcg gtgcgtatta ttatcgcgct cggtgtggca gggttaattg tcacccaggg gaccgatctt 
0211 tctgctggtc gtcaggtagg gctggcggca gtggtggctg cgacattatt gcagtccatg gataacgcca 
0281 acaaagtgtt cccggaaatg gcgacgatgc cgattgcgct ggttattctg attgtctgtg ccattggtgc 
0351 ggtgatcggt ttgatcaacg gtctgattat cgcttatctc aacgtgacgc cgttcattac cacgctcggc 
0421 acgatgatca tcgtctatgg catcaactcg ctctattacg actttgtcgg ggcgtcgcca atttctggtt 
0491 ttgacagtgg cttctctacc tttgctcagg gctttgtcgc gctggggagt ttccgtctct cttacatcac 
0561 cttctacgcg ttgattgcgg tggcgttcgt ctgggtgttg tggaacaaaa cccgcttcgg taagaacatt 
0631 tttgccattg gcggtaaccc ggaagcggca aaagtatctg gtgtcaacgt cggcctgaac ctgctgatga 
0701 tctacgcgtt gtctggcgtg ttctatgcct ttggcgggat gttagaagcc ggacgtatcg gctctgccac 
0771 caacaacctc ggctttatgt atgagctgga tgctatcgcg gcgtgcgtgg taggcggtgt atcgttcagc 
0841 ggcggtgtgg ggacggtgat tggcgtggtg accggggtaa ttatttttac cgtcatcaac tatggcctga 
0911 cgtatatcgg cgtaaaccca tactggcagt acatcatcaa aggggcgatt attatcttcg ccgtagcgct 
0981 ggattcactg aaatacgcgc gtaagaaatg atgtgaatgt ggtccgcatt cggtcataaa cgcacataac 
1051 atcatgatct gtgtggtttt gtaggccgga taaggcgttc acgccgcatc cggcaacagg a