|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
J Bacteriol. 1988;170(3):1069-75.
Lethality of a dut (deoxyuridine triphosphatase) mutation in Escherichia coli.
el-Hajj HH, Zhang H, Weiss B.
(
2830228
)
|
|
|
Deletion
|
16-1-2
(LD)
,
DE(sbcB-rfb)202
,
OCL74-2,75-5 (LD 16-1-2_CRS)
(D)
,
OCL74-2,75-6 (LD 16-1-2_P/O)
(D)
,
OCL74-3
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
dcd
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
dcd
Search strains by all related name:
dcd b2065 dus ECK2059 JW2050 paxA
|
General information (Go to Linear View: )
|
|
Gene Name
|
dcd
|
|
Alternative name
|
b2065,dus,ECK2059,JW2050,paxA
|
|
Location, Length
|
2,139,658 - 2,140,239
(
-
)
;
46.12
min
;
582
(bp) ,
193
(aa)
|
|
Product
|
2'-deoxycytidine 5'-triphosphate deaminase
|
|
Operon Name
|
udk-dcd
|
|
Note
|
GO_process: GO:0015949 - nucleobase, nucleoside and nucleotide interconversion
|
|
Function
|
enzyme; 2'-Deoxyribonucleotide metabolism
|
|
Gene Ontology
|
GO:0005515
;
protein binding ( dcd )
GO:0006229
;
dUTP biosynthetic process ( dcd )
GO:0008829
;
dCTP deaminase activity ( dcd )
GO:0009117
;
nucleotide metabolic process ( dcd )
GO:0009220
;
pyrimidine ribonucleotide biosynthetic process ( dcd )
GO:0016787
;
hydrolase activity ( dcd )
GO:0046080
;
dUTP metabolic process ( dcd )
|
|
PID
|
1788379
|
EC number
(KEGG Pathway)
|
3.5.4.13
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
dcd
(
EG11418
)
|
|
Number of removed
|
0 aa cleaved
|
|
SWISS-PROT
(
Show details
[
1
more]
)
|
Entry name(Acc.no)
|
DCD_ECOLI
(
P28248
)
|
|
- Protein name
|
Deoxycytidine triphosphate deaminase
|
|
- Synonyms
|
EC 3.5.4.13, dCTP deaminase
|
|
- Gene name
|
Name=dcd; Synonyms=dus, paxA; OrderedLocusNames=b2065;
|
|
Homology Analysis
|
|
BLAST
|
|
Bacteria
|
|
GTOP
|
dcd
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Dctp Deaminase From Escherichia Coli. E138a Mutant Enzyme In Complex With Dutp
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Deoxycytidine triphosphate deaminase
|
|
PSI-BLAST
|
Deoxycytidine triphosphate deaminase
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
deoxycytidine triphosphate deaminase [Escherichia coli K12]
|
|
Pfam 28.0
(database updated :
2015-05
)
|
|
Pfam
|
|
|
PROSITE
|
|
PROSITE
|
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
TYR_PHOSPHO_SITE
MYRISTYL
|
|
MMBR References
|
Mol Gen Genet. 1995;246(4):514-8.
An Escherichia coli strain deficient for both exonuclease V and deoxycytidine triphosphate deaminase shows enhanced sensitivity to ionizing radiation.
Estevenon AM, Kooistra J, Sicard N.
(
7891665
)
|
J Bacteriol. 1976;126(2):999-1001.
Altered deoxyribonucleotide pools in P2 eductants of Escherichia coli K-12 due to deletion of the dcd gene.
Neuhard J, Thomassen E.
(
177407
)
|
J Bacteriol. 1992;174:5647-5653
dcd (dCTP deaminase) gene of Escherichia coli: mapping, cloning, sequencing, and identification as a locus of suppressors of lethal dut (dUTPase) mutations.
Wang, L., and B. Weiss.
|
| Sequences |
Amino acid
FASTA format
|
0001 MRLCDRDIEA WLDEGRLSIN PRPPVERING ATVDVRLGNK FRTFRGHTAA FIDLSGPKDE VSAALDRVMS
0071 DEIVLDEGEA FYLHPGELAL AVTLESVTLP ADLVGWLDGR SSLARLGLMV HVTAHRIDPG WSGCIVLEFY
0141 NSGKLPLALR PGMLIGALSF EPLSGPAVRP YNRREDAKYR NQQGAVASRI DKD
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 tttgaataag cttgataaat tgtgtaccgt
-070 tcagtgataa cctagtatgc ccttgacgta attggcgtta agggagtgat gcgcgaaagg agaaaatgcc
0001 atgcgtctgt gtgaccgaga tattgaagcc tggcttgatg aaggccgttt gtcgatcaac ccacgtccgc
0071 cagtggagcg tattaacggc gcgacggtgg atgtacgcct gggcaataaa tttcgtacct tccgtggtca
0141 cacggcagcg tttatcgatc tgagcggtcc caaagatgaa gtgagcgccg cgcttgaccg cgtgatgagc
0211 gatgagatcg ttctcgacga gggcgaggcg ttctatcttc acccaggaga gctggcgctg gcggtgacgc
0281 tggagtcggt gacgctgcca gccgatctgg tgggctggct ggacgggcgt tcctcactgg cgcgtctggg
0351 gctgatggtg cacgtcaccg cgcaccgcat cgatccgggc tggtctggtt gcattgtgct ggagttctac
0421 aactccggta agctgccgct ggcgctgcgt ccgggcatgt taattggtgc gctgagcttt gagccgcttt
0491 ccggcccggc ggtgcgacct tacaaccgcc gtgaagatgc gaaatatcgc aaccagcagg gcgcggtagc
0561 cagccgaatc gataaagact aattcaggcc cattgaggat accatgagac gatttctgac gacgctgatg
0631 atactcctgg tcgtgctggt ggccgggtta tctgcgttag tgttgctggt ga
|
