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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
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Deletion
|
OCL78
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
uvrC
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Related strains
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Strains Search
|
Search strains by gene name:
uvrC
Search strains by all related name:
uvrC b1913 ECK1912 f588 JW1898
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General information (Go to Linear View: )
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Gene Name
|
uvrC
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Alternative name
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b1913,ECK1912,f588,JW1898
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Location, Length
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1,990,898 - 1,992,730
(
-
)
;
42.91
min
;
1833
(bp) ,
610
(aa)
|
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Product
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excinuclease UvrABC, endonuclease subunit
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Operon Name
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uvrYC
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Note
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excinuclease ABC, subunit C; repair of UV damage to DNA; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0006308 - DNA catabolic process; GO_process: GO:0006281 - DNA repair; GO_process: GO:0009314 - response to radiation
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Function
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enzyme; Degradation of DNA
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Gene Ontology
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GO:0003677
;
DNA binding ( uvrC )
GO:0004518
;
nuclease activity ( uvrC )
GO:0005622
;
intracellular ( uvrC )
GO:0005737
;
cytoplasm ( uvrC )
GO:0006281
;
DNA repair ( uvrC )
GO:0006289
;
nucleotide-excision repair ( uvrC )
GO:0006974
;
response to DNA damage stimulus ( uvrC )
GO:0009380
;
excinuclease repair complex ( uvrC )
GO:0009381
;
excinuclease ABC activity ( uvrC )
GO:0009432
;
SOS response ( uvrC )
GO:0043565
;
sequence-specific DNA binding ( uvrC )
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PID
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87081999
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EC number
(KEGG Pathway)
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Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
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EcoGene
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uvrC
(
EG11063
)
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Number of removed
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1 aa cleaved
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SWISS-PROT
(
Show details
)
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Entry name(Acc.no)
|
UVRC_ECOLI
(
P07028
;
P76311; Q8XBD5
)
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- Protein name
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UvrABC system protein C
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- Synonyms
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UvrC protein, Excinuclease ABC subunit C
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- Gene name
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Name=uvrC; OrderedLocusNames=b1913, c2326, z3001, ECs2651;
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MMBR References
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Gene. 1985;35(1-2):71-82.
Organisation and control of the Escherichia coli uvrC gene.
Forster JW, Strike P.
(
2993106
)
|
Mol Gen Genet. 1988;211(3):531-7.
Analysis of the regulatory elements of the Escherichia coli uvrC gene by construction of operon fusions.
Forster JW, Strike P.
(
2835638
)
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Nucleic Acids Res. 1987;15:4273-4289
Regulation of the Escherichia coli excision repair gene uvrC. Overlap between the uvrC structural gene and the region coding for a 24 kDa protein.
Moolenaar, G. F., C. A. Van Sluis, C. Backendorf, and P. Van de Putte.
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J Bacteriol. 1976;127(1):406-17.
Regulation of beta-glucuronidase synthesis in Escherichia coli K-12: constitutive mutants specifically derepressed for uidA expression.
Novel M, Novel G.
(
776933
)
|
Annu Rev Biochem. 1996;65:43-81.
DNA excision repair.
Sancar A.
(
8811174
)
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Proc Natl Acad Sci U S A. 1981;78:5450-5454
Identification of the uvrC gene product.
Sancar, A., B. M. Kacinski, D. L. Mott, and W. D. Rupp.
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Cell. 1983;33(1):249-60.
A novel repair enzyme: UVRABC excision nuclease of Escherichia coli cuts a DNA strand on both sides of the damaged region.
Sancar A, Rupp WD.
(
6380755
)
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Nucleic Acids Res. 1984;12:4593-4608
Sequences of the urrC gene and protein.
Sancar, G. B., A. Sancar, and W. D. Rupp.
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Nucleic Acids Res. 1982;10:5209-5221
Molecular structure of the uvrC gene of Escherichia coli: identification of DNA sequences required for transcription of the uvrC gene.
Sharma, R. C., W. Dowhan, and R. E. Moses.
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Proc Natl Acad Sci U S A. 1981;78:6033-6037
Cloning of the uvrC gene of Escherichia coli: expression of a DNA repair gene.
Sharma, S., A. Ohta, W. Dowhan, and R. E. Moses.
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Nucleic Acids Res. 1986;14:2301-2318
Multiple control elements for the uvrC gene unit of Escherichia coli.
Sharma, S., T. F. Stark, W. G. Beattie, and R. E. Moses.
|
J Bacteriol. 1982;152(2):773-9.
Molecular mapping of glyW, a duplicate gene for tRNA3Gly of Escherichia coli.
Tucker SD, Gopalakrishnan AS, Bollinger R, Dowhan W, Murgola EJ.
(
6290450
)
|
EMBO J. 1983;2(12):2313-8.
Regulation of the uvrC gene of Escherichia coli K12: localization and characterization of a damage-inducible promoter.
van Sluis CA, Moolenaar GF, Backendorf C.
(
6321159
)
|
Nature. 1981;292(5819):171-3.
Identification of E. coli uvrC protein.
Yoakum GH, Grossman L.
(
6264323
)
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| Sequences |
Amino acid
FASTA format
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0001 MSDQFDAKAF LKTVTSQPGV YRMYDAGGTV IYVGKAKDLK KRLSSYFRSN LASRKTEALV AQIQQIDVTV
0071 THTETEALLL EHNYIKLYQP RYNVLLRDDK SYPFIFLSGD THPRLAMHRG AKHAKGEYFG PFPNGYAVRE
0141 TLALLQKIFP IRQCENSVYR NRSRPCLQYQ IGRCLGPCVE GLVSEEEYAQ QVEYVRLFLS GKDDQVLTQL
0211 ISRMETASQN LEFEEAARIR DQIQAVRRVT EKQFVSNTGD DLDVIGVAFD AGMACVHVLF IRQGKVLGSR
0281 SYFPKVPGGT ELSEVVETFV GQFYLQGSQM RTLPGEILLD FNLSDKTLLA DSLSELAGRK INVQTKPRGD
0351 RARYLKLART NAATALTSKL SQQSTVHQRL TALASVLKLP EVKRMECFDI SHTMGEQTVA SCVVFDANGP
0421 LRAEYRRYNI TGITPGDDYA AMNQVLRRRY GKAIDDSKIP DVILIDGGKG QLAQAKNVFA ELDVSWDKNH
0491 PLLLGVAKGA DRKAGLETLF FEPEGEGFSL PPDSPALHVI QHIRDESHDH AIGGHRKKRA KVKNTSSLET
0561 IEGVGPKRRQ MLLKYMGGLQ GLRNASVEEI AKVPGISQGL AEKIFWSLKH
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 gctatcgtat gttcagtaaa ctaaacattc
-070 atggcgatgt tgagctgact cacctggcaa ttcgccatgg tctgtgtaat gcggagacat tatcaagtca
0001 gtgagtgatc agtttgacgc aaaagcgttt ttaaaaaccg taaccagcca gccaggcgtt tatcgcatgt
0071 acgatgctgg tggtacggtt atctatgtcg gcaaagcgaa agacctgaaa aaacggcttt ccagctattt
0141 ccgtagcaac ctcgcttcgc gcaaaaccga agcgctggtc gcccagatcc agcaaattga tgtaacggtt
0211 actcacacag aaaccgaagc gctgttgctg gaacacaact acatcaaact ctatcagccg cgttacaacg
0281 ttttgctacg cgatgataaa tcatatcctt ttatcttcct gagtggtgat acccacccgc gtctggcgat
0351 gcatcgtggt gcgaagcatg ccaaaggtga atatttcggc ccgttcccga atggctatgc cgtacgtgaa
0421 acactggcgc tactgcaaaa gattttcccc attcgccagt gcgaaaatag tgtttatcgc aatcgctcgc
0491 gtccgtgtct gcaataccag atagggcgct gtctgggacc gtgcgttgaa ggactggtga gtgaagaaga
0561 atacgctcag caggtcgagt atgtgcgcct gtttttgtct ggcaaagatg atcaggtgct tacgcaactc
0631 attagtcgta tggaaactgc cagccagaat ctggagtttg aagaagctgc acgtattcgc gaccaaattc
0701 aggcggtgcg acgcgtcacc gaaaaacaat tcgtttccaa taccggcgac gacctcgacg ttattggtgt
0771 ggcgttcgat gcgggcatgg cttgtgtcca cgtattgttc attcgtcagg gcaaagtgct cggcagccgc
0841 agctatttcc cgaaagtgcc tggcggtacg gaactgagcg aggtggtaga aaccttcgta ggccagttct
0911 atttacaagg cagccagatg cgcaccttac cgggtgagat cctgctcgat tttaatctta gcgataaaac
0981 gctgctcgcc gattcccttt cagaactggc gggacgcaag attaatgttc aaaccaaacc tcgcggcgat
1051 agggcgcgtt atctgaaact cgcgcgcacc aatgcggcga cggccttaac cagcaaactt tcgcagcaat
1121 ctaccgttca ccagcgactg accgcgcttg ccagcgtgtt gaaattgccg gaagtgaagc ggatggagtg
1191 ctttgacatc agccatacca tgggcgaaca aaccgtcgct tcctgtgtgg tgtttgatgc taacggcccg
1261 ctgcgtgcgg agtatcggcg ctataacatt acaggcatca cgccgggcga tgattatgcg gcgatgaatc
1331 aggtgctgcg tcggcgttat ggtaaagcca ttgacgacag taagatcccg gatgtgatcc ttatcgacgg
1401 cggcaaaggc cagcttgcgc aggcgaaaaa tgtcttcgcc gaactggatg tctcatggga taaaaatcat
1471 ccgctgctac ttggcgttgc caaaggagca gatcgtaagg ctggactgga aacgctgttc tttgagccgg
1541 aaggtgaggg atttagtttg ccgccagatt cacccgcgct gcatgttatc cagcatattc gcgatgaatc
1611 acatgatcac gcgattggcg ggcaccgtaa aaaacgggcg aaggtcaaaa ataccagttc cctggaaacc
1681 attgaaggcg tcgggccaaa acgtcggcaa atgttgttga aatatatggg cggtttgcaa ggtttacgta
1751 acgccagcgt cgaggaaatt gcaaaagtgc cgggtatttc gcaaggtctg gcagaaaaga tcttctggtc
1821 gttgaaacat tgatgtctct gtagcaacat aggggtaatc ttactgacaa cagatagtta cccgtcatta
1891 tgcaatttaa tatccctacg ttgcttacac tgttccgtgt cat
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