MG1655
W3110
Search for
Japanese | English
Gene Report : cheB
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Microbiol Mol Biol Rev. 1998;62(3):814-984
Linkage map of Escherichia coli K-12, edition 10: the traditional map.
Berlyn MK. ( 9729611 )
     Deletion LD3-32-1 (LD)  ,  OCL79 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  cheB
Related strains
     Strains Search Search strains by gene name:  cheB   Search strains by all related name:  cheB b1883 ECK1884 JW1872

General information  (Go to Linear View:)
 Gene Name cheB  
 Alternative name b1883,ECK1884,JW1872  
 Location, Length 1,965,476 - 1,966,525 (  -  ) ;   42.36 min ; 1050 (bp) ,   349 (aa) Go to Linear View
 Product fused chemotaxis regulator: protein-glutamate methylesterase in two-component regulatory system with CheA  
 Operon Name tar-tap-cheRBYZ  
 Note response regulator for chemotaxis (cheA sensor); protein methylesterase; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0006464 - protein modification process; GO_process: GO:0042330 - taxis  
 Function enzyme; Chemotaxis and mobility  
 Gene Ontology GO:0000156 ; two-component response regulator activity ( cheB )
GO:0000160 ; two-component signal transduction system (phosphorelay) ( cheB )
GO:0004871 ; signal transducer activity ( cheB )
GO:0005737 ; cytoplasm ( cheB )
GO:0006355 ; regulation of transcription, DNA-dependent ( cheB )
GO:0006935 ; chemotaxis ( cheB )
GO:0007165 ; signal transduction ( cheB )
GO:0007606 ; sensory perception of chemical stimulus ( cheB )
GO:0008984 ; protein-glutamate methylesterase activity ( cheB )
GO:0016787 ; hydrolase activity ( cheB )
 PID 1788192  
 EC number
  (KEGG Pathway)
 
3.1.1.61  
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) CHEB_ECOLI ( P07330 ; P78070 )
    -  Protein name Chemotaxis response regulator protein-glutamate methylesterase  
    -  Synonyms EC 3.1.1.61  
    -  Gene name Name=cheB; OrderedLocusNames=b1883;  

 Linear View (Whole Mode)
View Location
   1955.0  –  1980.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP cheB (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Structural Basis For Methylesterase Cheb Regulation By A Phosphorylation-Activated Domain  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Chemotaxis response regulator protein-glutamate methylesterase  
         PSI-BLAST Chemotaxis response regulator protein-glutamate methylesterase
    nr     (database updated : 2007.02.20 )
         BLAST chemotaxis-specific methylesterase [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL     

Other Cross-Reference
    COG COG2201NT 
    EcoCyc cheB 

MMBR References
Biochim Biophys Acta. 1992;1119(3):322-6.
Evidence that the methylesterase of bacterial chemotaxis may be a serine hydrolase.
Krueger JK, Stock J, Schutt CE. ( 1547277 )
J Bacteriol. 1986;165(1):161-6.
Nucleotide sequence corresponding to five chemotaxis genes in Escherichia coli.
Mutoh N, Simon MI. ( 3510184 )
J Bacteriol. 1983;155(2):565-77.
Genetics of methyl-accepting chemotaxis proteins in Escherichia coli: organization of the tar region.
Slocum MK, Parkinson JS. ( 6307970 )
J Biol Chem. 1993;268:1921-1930
Activating and inhibitory mutations in the regulatory domains of the methylesterase in bacterial chemotaxis.
Stewart, R. C.
Cell. 1981;26(3 Pt 1):333-43.
Sensory transducers of E. coli are encoded by homologous genes.
Boyd A, Krikos A, Simon M. ( 7034961 )
J Bacteriol. 1986;166(1):275-80.
Inversion of aerotactic response in Escherichia coli deficient in cheB protein methylesterase.
Dang CV, Niwano M, Ryu J, Taylor BL. ( 3007436 )

Sequences
Amino acid
FASTA format
0001 MSKIRVLSVD DSALMRQIMT EIINSHSDME MVATAPDPLV ARDLIKKFNP DVLTLDVEMP RMDGLDFLEK 
0071 LMRLRPMPVV MVSSLTGKGS EVTLRALELG AIDFVTKPQL GIREGMLAYN EMIAEKVRTA AKASLAAHKP 
0141 LSAPTTLKAG PLLSSEKLIA IGASTGGTEA IRHVLQPLPL SSPALLITQH MPPGFTRSFA DRLNKLCQIG 
0211 VKEAEDGERV LPGHAYIAPG DRHMELSRSG ANYQIKIHDG PAVNRHRPSV DVLFHSVAKQ AGRNAVGVIL 
0281 TGMGNDGAAG MLAMRQAGAW TLAQNEASCV VFGMPREAIN MGGVCEVVDL SQVSQQMLAK ISAGQAIRI

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             acggattgct gtttgcgggt cactctgaaa 
-070 actttagcca ccttgagcgc cgcttcacgc tgcgtggtca gacggtgtat gcgctaagta aggattaacg 
0001 atgagcaaaa tcagggtgtt atctgtcgat gattcggcac tgatgcgcca gatcatgaca gaaatcatca 
0071 acagccatag cgacatggaa atggtggcga ccgcgcctga tccgctggtc gcgcgtgact tgattaagaa 
0141 attcaatccc gatgtgctga cgctggatgt tgaaatgccg cggatggacg gactggattt cctcgaaaaa 
0211 ttaatgcgtt tgcgtccaat gcccgttgtg atggtttctt ccctgaccgg caaagggtca gaagtcacgc 
0281 tgcgcgcgct ggagctgggg gcgatagatt ttgtcaccaa accgcaactg ggtattcgcg aaggtatgct 
0351 ggcgtataac gaaatgattg ctgaaaaggt gcgtacggca gcaaaggcga gccttgcagc acataagcca 
0421 ttgtcggcac cgacaacgct gaaggcgggg ccgttgttga gttctgaaaa actgattgcg attggtgctt 
0491 caacgggtgg aactgaggca attcgtcacg tactgcaacc gttgccgctt tccagcccgg cactgttaat 
0561 tacccagcat atgccgcccg gtttcacccg ctcttttgcc gacagactta ataagctttg ccagatcggg 
0631 gttaaagaag ccgaagacgg agaacgtgtc ttgccggggc atgcctatat tgcgccgggc gatcggcata 
0701 tggagctgtc gcgtagtggc gcaaattacc aaatcaaaat tcacgatggc ccggcggtta accgtcatcg 
0771 gccttcggta gatgtgttgt tccattctgt cgccaaacag gcggggcgta atgcggttgg ggtgatcctg 
0841 accggtatgg gcaacgacgg cgcggcggga atgttggcga tgcgtcaggc gggggcatgg acccttgcgc 
0911 aaaacgaagc aagttgcgtg gtgttcggca tgccgcgcga ggccatcaat atgggtggtg tctgcgaagt 
0981 ggtcgatctt agccaggtaa gccagcaaat gttggcaaaa attagtgccg gacaggcgat acgtatttaa 
1051 atcaggagtg tgaaatggcg gataaagaac ttaaattttt ggttgtggat gacttttcca ccatgcgacg 
1121 catagtgcgt aacctgctga aagagctggg