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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
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Deletion
|
OCL82
(D)
|
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Related gene (W3110 PEC)
|
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Gene Search
|
Search MG1655 PEC by gene name:
manY
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Related strains
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Strains Search
|
Search strains by gene name:
manY
Search strains by all related name:
manY b1818 ECK1816 JW1807 pel ptsM ptsP ptsX
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General information (Go to Linear View: )
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Gene Name
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manY
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Alternative name
|
b1818,ECK1816,JW1807,pel,ptsM,ptsP,ptsX
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Location, Length
|
1,901,106 - 1,901,906
(
+
)
;
40.97
min
;
801
(bp) ,
266
(aa)
|
|
Product
|
mannose-specific enzyme IIC component of PTS
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Operon Name
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manXYZ
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Note
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PTS enzyme IIC, mannose-specific; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0016052 - carbohydrate catabolic process
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Function
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transport; Transport of small molecules: Carbohydrates, organic acids, alcohols
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Gene Ontology
|
GO:0003824
;
catalytic activity ( ptsP )
GO:0005351
;
sugar:hydrogen ion symporter activity ( manY )
GO:0005351
;
sugar:hydrogen ion symporter activity ( ptsP )
GO:0005737
;
cytoplasm ( ptsP )
GO:0005886
;
plasma membrane ( manY )
GO:0006810
;
transport ( manY )
GO:0006810
;
transport ( ptsP )
GO:0008643
;
carbohydrate transport ( manY )
GO:0008643
;
carbohydrate transport ( ptsP )
GO:0008965
;
phosphoenolpyruvate-protein phosphotransferase activity ( ptsP )
GO:0009401
;
phosphoenolpyruvate-dependent sugar phosphotransferase system ( manY )
GO:0009401
;
phosphoenolpyruvate-dependent sugar phosphotransferase system ( ptsP )
GO:0016020
;
membrane ( manY )
GO:0016021
;
integral to membrane ( manY )
GO:0016301
;
kinase activity ( ptsP )
GO:0016310
;
phosphorylation ( ptsP )
GO:0016740
;
transferase activity ( ptsP )
GO:0016772
;
transferase activity, transferring phosphorus-containing groups ( ptsP )
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PID
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1788121
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EC number
(KEGG Pathway)
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SWISS-PROT
(
Show details
[
4
more]
)
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Entry name(Acc.no)
|
PTNC_ECOLI
(
P08187
;
Q47351
)
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- Protein name
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PTS system, mannose-specific IIC component
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- Synonyms
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EIIC-Man, Mannose- permease IIC component, Phosphotransferase enzyme II, C component, EII-P-Man
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- Gene name
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OrderedLocusNames=b1818, c2224, z2861, ECs2528, SF1410, S1525;
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Homology Analysis
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BLAST
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Bacteria
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GTOP
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manY
(
homologous genes of other bacterias
)
ptsP
(
homologous genes of other bacterias
)
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PDB
(database updated :
2007.02.20
)
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PSI-BLAST
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SWISS-PROT
(database updated :
2007.02.20
)
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BLAST
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Mannose permease IIC component (PTS system mannose-specific EIIC component) (EIIC-Man) (EII-P-Man)
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PSI-BLAST
|
Mannose permease IIC component (PTS system mannose-specific EIIC component) (EIIC-Man) (EII-P-Man)
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nr
(database updated :
2007.02.20
)
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BLAST
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PTS enzyme IIC, mannose-specific [Escherichia coli O157:H7 EDL933]
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Pfam 28.0
(database updated :
2015-05
)
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Pfam
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PROSITE
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PROSITE
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ASN_GLYCOSYLATION
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
PROKAR_LIPOPROTEIN
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MMBR References
|
J Biol Chem. 1985;260:15495-15503
The mannose-permease of the bacterial phosphotransferase system. Gene cloning and purification of the enzyme IIMan/IIIMan complex of Escherichia coli.
Erni, B., and B. Zanolari.
|
J Biol Chem. 1987;262:5238-5247
The mannose permease of Escherichia coli consists of three different proteins: amino acid sequence and function in sugar transport, sugar phosphorylation, and penetration of phage lambda DNA.
Erni, B., B. Zanolari, and H. P. Kocher.
|
Eur J Biochem. 1996;239:810-817
Membrane topology of the mannose transporter of Escherichia coli K12.
Huber, F., and B. Erni.
|
Mol Gen Genet. 1985;199(3):427-33.
Gene fusions to the ptsM/pel locus of Escherichia coli.
Palva ET, Saris P, Silhavy TJ.
(
3162078
)
|
Proc Natl Acad Sci U S A. 1986;83:8934-8938
Pel, the protein that permits lambda DNA penetration of Escherichia coli, is encoded by a gene in ptsM and is required for mannose utilization by the phosphotransferase system.
Williams, N., D. K. Fox, C. Shea, and S. Roseman.
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| Sequences |
Amino acid
FASTA format
|
0001 MEITTLQIVL VFIVACIAGM GSILDEFQFH RPLIACTLVG IVLGDMKTGI IIGGTLEMIA LGWMNIGAAV
0071 APDAALASII STILVIAGHQ SIGAGIALAI PLAAAGQVLT IIVRTITVAF QHAADKAADN GNLTAISWIH
0141 VSSLFLQAMR VAIPAVIVAL SVGTSEVQNM LNAIPEVVTN GLNIAGGMIV VVGYAMVINM MRAGYLMPFF
0211 YLGFVTAAFT NFNLVALGVI GTVMAVLYIQ LSPKYNRVAG APAQAAGNND LDNELD
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 TGAAAATGAT GGATCTGATC AGCAAAATCG
-070 ATAAGTAACG TATTGTGTTG ATTATCACTC AGTTTTCACA CTTAAGTCTT ACGTAAACAG GAGAAGTACA
0001 atggagatta ccactcttca aattgtgctg gtatttatcg tagcctgtat cgcaggtatg ggatcaatcc
0071 tcgatgaatt tcagtttcac cgtccgctaa tcgcgtgtac cctggtgggt atcgttcttg gggatatgaa
0141 aaccggtatt attatcggtg gtacgctgga aatgatcgcg ctgggctgga tgaacatcgg tgctgcagtt
0211 gcgcctgacg ccgctctggc ttctatcatt tctaccattc tggttatcgc aggtcatcag agcattggtg
0281 caggtatcgc actggcaatc cctctggccg ctgcgggcca ggtactgacc atcatcgttc gtactattac
0351 cgttgctttc cagcacgctg cggataaggc tgctgataac ggcaacctga cagcgatttc ctggatccac
0421 gtttcttctc tgttcctgca agcaatgcgt gtggctattc cggccgtcat cgttgcgctg tctgttggta
0491 ccagcgaagt acagaacatg ctgaatgcga ttccggaagt ggtgaccaat ggtctgaata tcgccggtgg
0561 catgatcgtg gtggttggtt atgcgatggt tatcaacatg atgcgtgctg gctacctgat gccgttcttc
0631 tacctcggct tcgtaaccgc agcattcacc aactttaacc tggttgctct gggtgtgatt ggtactgtta
0701 tggcagtgct ctacatccaa cttagcccga aatacaaccg cgtagccggt gcgcctgctc aggcagctgg
0771 taacaacgat ctcgataacg aactggacta aCAGGTGAGC GAAATGGTTG ATACAACTCA AACTACCACC
0841 GAGAAAAAAC TCACTCAAAG TGATATTCGT GGCGTCTTCC TGCGTTCTAA CCTCTTCCAG G
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