MG1655
W3110
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Gene Report : xthA
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)  
     Deletion LD3-17-1 (LD)  ,  OCL84,85-1 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  xthA
Related strains
     Strains Search Search strains by gene name:  xthA   Search strains by all related name:  xthA b1749 ECK1747 JW1738 xth

General information  (Go to Linear View:)
 Gene Name xthA  
 Alternative name b1749,ECK1747,JW1738,xth  
 Location, Length 1,830,452 - 1,831,258 (  +  ) ;   39.45 min ; 807 (bp) ,   268 (aa) Go to Linear View
 Product exonuclease III  
 Operon Name xthA  
 Note GO_process: GO:0006308 - DNA catabolic process; GO_process: GO:0009314 - response to radiation  
 Function enzyme; Degradation of DNA  
 Gene Ontology GO:0000287; magnesium ion binding ( xthA )
GO:0003677; DNA binding ( xthA )
GO:0003824; catalytic activity ( xthA )
GO:0004518; nuclease activity ( xthA )
GO:0004519; endonuclease activity ( xthA )
GO:0004527; exonuclease activity ( xthA )
GO:0005622; intracellular ( xthA )
GO:0006281; DNA repair ( xthA )
GO:0006974; response to DNA damage stimulus ( xthA )
GO:0008853; exodeoxyribonuclease III activity ( xthA )
GO:0016787; hydrolase activity ( xthA )
GO:0046872; metal ion binding ( xthA )
 PID 1788046  
 EC number
  (KEGG Pathway)
 
3.1.11.2  
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) EX3_ECOLI ( P09030 )
    -  Protein name Exodeoxyribonuclease III  
    -  Synonyms EC 3.1.11.2, Exonuclease III, EXO III, AP endonuclease VI  
    -  Gene name Name=xthA; Synonyms=xth; OrderedLocusNames=b1749;  

 Linear View (Whole Mode)
View Location
   1820.0  –  1845.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP xthA (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain , Exonuclease Iii From Escherichia Coli  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Exodeoxyribonuclease III  
         PSI-BLAST Exodeoxyribonuclease III
    nr     (database updated : 2007.02.20 )
         BLAST exonuclease III [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    AP_NUCLEASE_F1_1    AP_NUCLEASE_F1_2    AP_NUCLEASE_F1_3     

Other Cross-Reference
    COG COG0708L 
    EcoCyc xthA 

MMBR References
Gene. 1980;11(3-4):187-95.
Cloning of the exonuclease III gene of Escherichia coli.
Rogers SG, Weiss B. ( 6260569 )
J Bacteriol. 1988;170(10):4542-7.
Nucleotide sequence of the xth gene of Escherichia coli K-12.
Saporito SM, Smith-White BJ, Cunningham RP. ( 3049539 )
Nucleic Acids Symp Ser. 1995;24:87-88.
The recognition of DNA containing an AP site by E. coli endonuclease VI (exonuclease III).
Shida, T., M. Noda, and J. Sekiguchi.

Sequences
Amino acid
FASTA format
0001 MKFVSFNING LRARPHQLEA IVEKHQPDVI GLQETKVHDD MFPLEEVAKL GYNVFYHGQK GHYGVALLTK 
0071 ETPIAVRRGF PGDDEEAQRR IIMAEIPSLL GNVTVINGYF PQGESRDHPI KFPAKAQFYQ NLQNYLETEL 
0141 KRDNPVLIMG DMNISPTDLD IGIGEENRKR WLRTGKCSFL PEEREWMDRL MSWGLVDTFR HANPQTADRF 
0211 SWFDYRSKGF DDNRGLRIDL LLASQPLAEC CVETGIDYEI RSMEKPSDHA PVWATFRR

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             CATTAACAAC CATCGATCAA ATCACTTAAC 
-070 AACAGGCGGT AAGCAACGCG AAATTCTGCT ACCATCCACG CACTCTTTAT CTGAATAAAT GGCAGCGACT 
0001 atgaaatttg tctcttttaa tatcaacggc ctgcgcgcca gacctcacca gcttgaagcc atcgtcgaaa 
0071 agcaccaacc ggatgtgatt ggcctgcagg agacaaaagt tcatgacgat atgtttccgc tcgaagaggt 
0141 ggcgaagctc ggctacaacg tgttttatca cgggcagaaa ggccattatg gcgtggcgct gctgaccaaa 
0211 gagacgccga ttgccgtgcg tcgcggcttt cccggtgacg acgaagaggc gcagcggcgg attattatgg 
0281 cggaaatccc ctcactgctg ggtaatgtca ccgtgatcaa cggttacttc ccgcagggtg aaagccgcga 
0351 ccatccgata aaattcccgg caaaagcgca gttttatcag aatctgcaaa actacctgga aaccgaactc 
0421 aaacgtgata atccggtact gattatgggc gatatgaata tcagccctac agatctggat atcggcattg 
0491 gcgaagaaaa ccgtaagcgc tggctgcgta ccggtaaatg ctctttcctg ccggaagagc gcgaatggat 
0561 ggacaggctg atgagctggg ggttggtcga taccttccgc catgcgaatc cgcaaacagc agatcgtttc 
0631 tcatggtttg attaccgctc aaaaggtttt gacgataacc gtggtctgcg catcgacctg ctgctcgcca 
0701 gccaaccgct ggcagaatgt tgcgtagaaa ccggcatcga ctatgaaatc cgcagcatgg aaaaaccgtc 
0771 cgatcacgcc cccgtctggg cgaccttccg ccgctaaTTT AGCAGCTCTC CTGGCTCAAA CTGGGTCAGG 
0841 AGAATTAACC TTGAGAAAAA TCAACAAACT GTCAGTAATG ATTTGTTGCC TGCCGTCCTT TGTTATA