MG1655
W3110
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Gene Report : infC
PEC Original Annotations
Essentiality
     Class essential
     References (PMID)
Biochemistry. 1990;29(25):5881-9.
Initiation of mRNA translation in prokaryotes.
Gualerzi CO, Pon CL. ( 2200518 )
     Deletion OCL85,86-8 (AK4-4 / BK6-4) (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  infC
Related strains
     Strains Search Search strains by gene name:  infC   Search strains by all related name:  infC b1718 ECK1716 fit JW5829 srjA

General information  (Go to Linear View:)
 Gene Name infC  
 Alternative name b1718,ECK1716,fit,JW5829,srjA  
 Location, Length 1,798,120 - 1,798,662 (  -  ) ;   38.76 min ; 543 (bp) ,   180 (aa) Go to Linear View
 Product protein chain initiation factor IF-3  
 Operon Name thrS-infC-rpmI-rplT-pheMST-ihfA  
 Note GO_component: GO:0005737 - cytoplasm; GO_process: GO:0006412 - translation  
 Function factor; Proteins - translation and modification  
 Gene Ontology GO:0003723; RNA binding ( infC )
GO:0003743; translation initiation factor activity ( infC )
GO:0005737; cytoplasm ( infC )
GO:0006412; translation ( infC )
GO:0006413; translational initiation ( infC )
GO:0006417; regulation of translation ( infC )
 PID 1788012  
 EC number
  (KEGG Pathway)
 
 
Verified Protein Starts (data compiled from literature and appropriate citations are available from EcoGene)
     EcoGene infC ( EG10506 )  
    Number of removed 0 aa cleaved  
SWISS-PROT  ( Show details )
  botton Entry name(Acc.no) IF3_ECOLI ( P02999 ; P76905 )
    -  Protein name Translation initiation factor IF-3.  
    -  Synonyms  
    -  Gene name OrderedLocusNames=b1718, c2115, z2747, ECs2425;  

 Linear View (Whole Mode)
View Location
   1785.0  –  1810.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP infC (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain , Translation Initiation Factor 3 C-Terminal Domain  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Translation initiation factor IF-3 [Contains: IF-3L; IF-3S]  
         PSI-BLAST Translation initiation factor IF-3
    nr     (database updated : 2007.02.20 )
         BLAST translation initiation factor IF-3 [Escherichia coli O157:H7 str. Sakai]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    TYR_PHOSPHO_SITE    MYRISTYL    AMIDATION    IF3     

Other Cross-Reference
    COG COG0290J 
    EcoCyc infC 

MMBR References
J Bacteriol. 1982;152(1):357-62.
Molecular cloning and regulation of expression of the genes for initiation factor 3 and two aminoacyl-tRNA synthetases.
Elseviers D, Gallagher P, Hoffman A, Weinberg B, Schwartz I. ( 6749810 )
J Bacteriol. 1993;175:6118-6125
Suppression of recJ mutations of Escherichia coli by mutations in translation initiation factor IF3.
Haggerty, T. J., and S. T. Lovett.
J Mol Biol. 1992;228(2):366-86.
Messenger RNA secondary structure and translational coupling in the Escherichia coli operon encoding translation initiation factor IF3 and the ribosomal proteins, L35 and L20.
Lesage P, Chiaruttini C, Graffe M, Dondon J, Milet M, Springer M. ( 1453449 )
J Bacteriol. 1991;173(12):3888-93.
Growth rate regulation of translation initiation factor IF3 biosynthesis in Escherichia coli.
Liveris D, Klotsky RA, Schwartz I. ( 2050639 )
Proc Natl Acad Sci U S A. 1983;80:6152-6156
Structural and transcriptional evidence for related thrS and infC expression.
Mayaux, J.-F., G. Fayat, M. Fromant, M. Springer, and M. Grunberg-Manago.
Gene. 1989;80(2):369-74.
Inducible high expression of the Escherichia coli infC gene subcloned behind a bacteriophage T7 promoter.
Muralikrishna P, Wickstrom E. ( 2684768 )
Gene. 1980;11(1-2):33-42.
Physical localisation and cloning of the structural gene for E. coli initiation factor IF3 from a group of genes concerned with translation.
Plumbridge JA, Springer M, Graffe M, Goursot R, Grunberg-Manago M. ( 6254853 )
J Bacteriol. 1986;168(2):746-51.
Expression of Escherichia coli infC: identification of a promoter in an upstream thrS coding sequence.
Pramanik A, Wertheimer SJ, Schwartz JJ, Schwartz I. ( 3536858 )
EMBO J. 1982;1(3):311-5.
Sequence of a 1.26-kb DNA fragment containing the structural gene for E.coli initiation factor IF3: presence of an AUU initiator codon.
Sacerdot C, Fayat G, Dessen P, Springer M, Plumbridge JA, Grunberg-Manago M, Blanquet S. ( 6325158 )
Mol Gen Genet. 1982;186(2):247-52.
Transcription units around the gene for E. coli translation initiation factor IF3 (infC).
Springer M, Plumbridge JA, Trudel M, Graffe M, Grunberg-Manago M. ( 7050631 )
Gene. 1988;63(2):309-20.
Transcriptional patterns for the thrS-infC-rplT operon of Escherichia coli.
Wertheimer SJ, Klotsky RA, Schwartz I. ( 2838394 )
J Mol Biol. 1984;173(2):177-209.
Transcription of a gene cluster coding for two aminoacyl-tRNA synthetases and an initiation factor in Escherichia coli.
Wu TH, Wood DL, Stein PL, Comer MM. ( 6368838 )
Mol Gen Genet. 1987;208(1-2):94-100.
The unusual translational initiation codon AUU limits the expression of the infC (initiation factor IF3) gene of Escherichia coli.
Brombach M, Pon CL. ( 3302616 )
J Mol Biol. 1986;192(4):767-80.
Escherichia coli protein synthesis initiation factor IF3 controls its own gene expression at the translational level in vivo.
Butler JS, Springer M, Dondon J, Graffe M, Grunberg-Manago M. ( 2438418 )
Proc Natl Acad Sci U S A. 1987;84:4022-4025
AUU-to-AUG mutation in the initiator codon of the translation initiation factor IF3 abolishes translational autocontrol of its own gene (infC) in vivo.
Butler, J. S., M. Springer, and M. Grunberg-Manago.
Proc Natl Acad Sci U S A. 1997;94:9208-9213
Translational coupling by modulation of feedback repression in the IF3 operon of Escherichia coli.
Chiaruttini, C., M. Milet, and M. Springer.
Mol Gen Genet. 1985;198(2):299-303.
Intragenic suppression of the temperature-sensitivity caused by a mutation in a gene controlling transcription (fit) in Escherichia coli.
Dass SB, Jayaraman R. ( 2580214 )

Sequences
Amino acid
FASTA format
0001 MKGGKRVQTA RPNRINGEIR AQEVRLTGLE GEQLGIVSLR EALEKAEEAG VDLVEISPNA EPPVCRIMDY 
0071 GKFLYEKSKS SKEQKKKQKV IQVKEIKFRP GTDEGDYQVK LRSLIRFLEE GDKAKITLRF RGREMAHQQI 
0141 GMEVLNRVKD DLQELAVVES FPTKIEGRQM IMVLAPKKKQ 

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             ccgtggtaaa gacctgggaa gcatggacgt 
-070 aaatgaagtg atcgagaagc tgcaacaaga gattcgcagc cgcagtctta aacaattgga ggaataaggt 
0001 attaaaggcg gaaaacgagt tcaaacggcg cgccctaacc gtatcaatgg cgaaattcgc gcccaggaag 
0071 ttcgcttaac aggtctggaa ggcgagcagc ttggtattgt gagtctgaga gaagctctgg agaaagcaga 
0141 agaagccgga gtagacttag tcgagatcag ccctaacgcc gagccgccgg tttgtcgtat aatggattac 
0211 ggcaaattcc tctatgaaaa gagcaagtct tctaaggaac agaagaaaaa gcaaaaagtt atccaggtta 
0281 aggaaattaa attccgtcct ggtacagatg aaggcgacta tcaggtaaaa ctccgcagcc tgattcgctt 
0351 tctcgaagag ggtgataaag ccaaaatcac gctgcgtttc cgcggtcgtg agatggcgca ccagcaaatc 
0421 ggtatggaag tgcttaatcg cgtgaaagac gatttgcaag aactggcagt ggtcgaatcc ttcccaacga 
0491 agatcgaagg ccgccagatg atcatggtgc tcgctcctaa gaagaaacag taaggccttc aagtagcact 
0561 gtctgtggag ccttcgggct tcacaggctt tgttcgcctt tgtttcgttt attaacaatg cgaagtggaa 
0631 gttattaaaa tgc