MG1655
W3110
Search for
Japanese | English
Gene Report : ihfA
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
     Deletion OCL85,86-8 (AK4-4 / BK6-4) (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  ihfA
Related strains
     Strains Search Search strains by gene name:  ihfA   Search strains by all related name:  ihfA b1712 ECK1710 hid himA JW1702

General information  (Go to Linear View:)
 Gene Name ihfA  
 Alternative name b1712,ECK1710,hid,himA,JW1702  
 Location, Length 1,793,277 - 1,793,576 (  -  ) ;   38.65 min ; 300 (bp) ,   99 (aa) Go to Linear View
 Product integration host factor (IHF), DNA-binding protein, alpha subunit  
 Operon Name thrS-infC-rpmI-rplT-pheMST-ihfA  
 Note integration host factor (IHF), alpha subunit; site specific recombination; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0006310 - DNA recombination  
 Function factor; DNA - replication, repair,restriction/modification  
 Gene Ontology GO:0003677; DNA binding ( ihfA )
GO:0005694; chromosome ( ihfA )
GO:0006310; DNA recombination ( ihfA )
GO:0006350; transcription ( ihfA )
GO:0006355; regulation of transcription, DNA-dependent ( ihfA )
GO:0006417; regulation of translation ( ihfA )
 PID 1788005  
 EC number
  (KEGG Pathway)
 
 
SWISS-PROT  ( Show details )
  botton Entry name(Acc.no) IHFA_ECOLI ( P06984 )
    -  Protein name Integration host factor alpha-subunit  
    -  Synonyms IHF-alpha  
    -  Gene name OrderedLocusNames=b1712, c2109, z2741, ECs2419, SF1519, S1636;  

 Linear View (Whole Mode)
View Location
   1780.0  –  1805.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP ihfA (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Crystal Structure Of An Ihf-Dna Complex: A Protein-Induced Dna U-Turn  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Integration host factor subunit alpha (IHF-alpha)  
         PSI-BLAST Integration host factor subunit alpha (IHF-alpha)
    nr     (database updated : 2007.02.20 )
         BLAST integration host factor alpha subunit [Escherichia coli O157:H7 EDL933]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE GLYCOSAMINOGLYCAN    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    HISTONE_LIKE     

Other Cross-Reference
    EcoCyc ihfA 

MMBR References
Nucleic Acids Res. 1995;23:2959-2965
In vivo interaction of the Escherichia coli integration host factor with its specific binding sites
Engelhorn, M., F. Boccard, C. Murtin, P. Prentki, and J. Geiselmann.
Nucleic Acids Res. 1996;24:1780-1786
Examining the contribution of a dA+dT element to the conformation of Escherichia coli integration host factor-DNA complexes.
Hales, L. M., R. I. Gumport, and J. F. Gardner.
EMBO J. 1992;11:305-313
The isolation and characterization of mutants of the integration host factor (IHF) of Escherichia coli with altered, expanded DNA-binding specificities.
Lee, E. C., L. M. Hales, R. I. Gumport, and J. F. Gardner.
J Bacteriol. 1985;163(2):787-91.
Sequence of the Escherichia coli pheST operon and identification of the himA gene.
Mechulam Y, Fayat G, Blanquet S. ( 2991205 )
J Mol Biol. 1987;197(3):453-70.
Dual level control of the Escherichia coli pheST-himA operon expression. tRNA(Phe)-dependent attenuation and transcriptional operator-repressor control by himA and the SOS network.
Mechulam Y, Blanquet S, Fayat G. ( 3326947 )
J Bacteriol. 1991;173(5):1670-6.
HU and integration host factor function as auxiliary proteins in cleavage of phage lambda cohesive ends by terminase.
Mendelson I, Gottesman M, Oppenheim AB. ( 1825651 )
Cold Spring Harbor Symp. Quant. Biol. 1984;49:691-8.
Primary structure of the himA gene of Escherichia coli: homology with DNA-binding protein HU and association with the phenylalanyl-tRNA synthetase operon.
Miller HI. ( 6397321 )
Cold Spring Harbor Symp. Quant. Biol. 1977;42:349-356.
Isolation of Escherichia coli mutants unable to support lambda integrative recombination.
Miller, H. I., and D. I. Friedman.
Cell. 1980;20(3):711-9.
An E. coli gene product required for lambda site-specific recombination.
Miller HI, Friedman DI. ( 6251971 )
Nature. 1981;290(5806):523-6.
Direct role of the himA gene product in phage lambda integration.
Miller HI, Nash HA. ( 6261146 )
Proc Natl Acad Sci U S A. 1981;78:6754-6758
SOS induction and autoregulation of the himA gene for site-specific recombination in Escherichia coli.
Miller, H. I., M. Kirk, and H. Echols.
Cold Spring Harbor Symp. Quant. Biol. 1978;43:1121-1126.
Site-specific recombination of bacteriophage lambda : the role of host gene products.
Miller, H. I., Y. Kikuchi, H. A. Nash, R. Weisberg, and D. I. Friedman.
J Bacteriol. 1995;177:5707-5710
Glucose starvation stimulon of Escherichia coli: role of integration host factor in starvation survival and growth phase-dependent protein synthesis.
Nystrom, T.
Annu Rev Physiol. 1997;59:633-57.
Mechanosensitive channels of Escherichia coli: the MscL gene, protein, and activities.
Sukharev SI, Blount P, Martinac B, Kung C. ( 9074781 )
Mol Gen Genet. 1993;237(1-2):273-86.
Integration host factor (IHF) modulates the expression of the pyrimidine-specific promoter of the carAB operons of Escherichia coli K12 and Salmonella typhimurium LT2.
Charlier D, Roovers M, Gigot D, Huysveld N, Pierard A, Glansdorff N. ( 8455562 )
J Bacteriol. 1981;146(1):269-74.
Gene organization around the phenylalanyl-transfer ribonucleic acid synthetase locus in Escherichia coli.
Comer MM. ( 7012115 )

Sequences
Amino acid
FASTA format
0001 MALTKAEMSE YLFDKLGLSK RDAKELVELF FEEIRRALEN GEQVKLSGFG NFDLRDKNQR PGRNPKTGED 
0071 IPITARRVVT FRPGQKLKSR VENASPKDE

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             accagccgta cactcgaaga agaggagatt 
-070 gccgctaccg tcgccaaatg tgtagaggca ttaaaagagc gattccaggc atcattgagg gattgaacct 
0001 atggcgctta caaaagctga aatgtcagaa tatctgtttg ataagcttgg gcttagcaag cgggatgcca 
0071 aagaactggt tgaactgttt ttcgaagaga tccgtcgcgc tctggaaaac ggcgaacagg tgaaactctc 
0141 tggttttggt aacttcgatc tgcgtgataa gaatcaacgc ccgggacgta acccgaaaac gggcgaggat 
0211 attcccatta cagcacggcg cgtggtgacc ttcagacccg ggcagaagtt aaaaagccgg gtcgaaaacg 
0281 cttcgcccaa agacgagtaa tctgatctaa ctaaaaaggc cgctctgcgg ccttttttct tttcactgtc 
0351 gaagagtcac cgtaaaatca acgccatgac acttcagcag aacggatacc