MG1655
W3110
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Gene Report : aroD
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Vaccine. 1992;10(11):766-76.
Genotypic and phenotypic characterization of an aroD deletion-attenuated Escherichia coli K12-Shigella flexneri hybrid vaccine expressing S. flexneri 2a somatic antigen.
Newland JW, Hale TL, Formal SB. ( 1441732 )
     Deletion OCL87 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  aroD
Related strains
     Strains Search Search strains by gene name:  aroD   Search strains by all related name:  aroD b1693 ECK1691 JW1683

General information  (Go to Linear View:)
 Gene Name aroD  
 Alternative name b1693,ECK1691,JW1683  
 Location, Length 1,772,710 - 1,773,468 (  +  ) ;   38.21 min ; 759 (bp) ,   252 (aa) Go to Linear View
 Product 3-dehydroquinate dehydratase  
 Operon Name ydiNB-aroD  
 Note GO_process: GO:0009423 - chorismate biosynthetic process  
 Function enzyme; Amino acid biosynthesis: Chorismate  
 Gene Ontology GO:0003824; catalytic activity ( aroD )
GO:0003855; 3-dehydroquinate dehydratase activity ( aroD )
GO:0008152; metabolic process ( aroD )
GO:0008652; amino acid biosynthetic process ( aroD )
GO:0009073; aromatic amino acid family biosynthetic process ( aroD )
GO:0016829; lyase activity ( aroD )
 PID 1787984  
 EC number
  (KEGG Pathway)
 
4.2.1.10  
Verified Protein Starts (data compiled from literature and appropriate citations are available from EcoGene)
     EcoGene aroD ( EG10076 )  
    Number of removed 0 aa cleaved  
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) AROD_ECOLI ( P05194 )
    -  Protein name 3-dehydroquinate dehydratase  
    -  Synonyms EC 4.2.1.10, 3-dehydroquinase, Type I DHQase  
    -  Gene name Name=aroD; OrderedLocusNames=b1693;  

 Linear View (Whole Mode)
View Location
   1760.0  –  1785.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP aroD (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, The Structure Of Type I 3-Dehydroquinate Dehydratase From Salmonella Typhi  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST 3-dehydroquinate dehydratase  
         PSI-BLAST 3-dehydroquinate dehydratase
    nr     (database updated : 2007.02.20 )
         BLAST 3-dehydroquinate dehydratase [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE CAMP_PHOSPHO_SITE    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    DEHYDROQUINASE_I     

Other Cross-Reference
    EcoCyc aroD 

MMBR References
Gene. 1981;14(1-2):73-80.
The cloning and analysis of the aroD gene of E. coli K-12.
Kinghorn JR, Schweizer M, Giles NH, Kushner SR. ( 7021325 )
J Bacteriol. 1987;169(5):1949-53.
Defective regulation of the phenylalanine biosynthetic operon in mutants of the phenylalanyl-tRNA synthetase operon.
Borg-Olivier SA, Tarlinton D, Brown KD. ( 3032903 )

Sequences
Amino acid
FASTA format
0001 MKTVTVKDLV IGTGAPKIIV SLMAKDIASV KSEALAYREA DFDILEWRVD HYADLSNVES VMAAAKILRE 
0071 TMPEKPLLFT FRSAKEGGEQ AISTEAYIAL NRAAIDSGLV DMIDLELFTG DDQVKETVAY AHAHDVKVVM 
0141 SNHDFHKTPE AEEIIARLRK MQSFDADIPK IALMPQSTSD VLTLLAATLE MQEQYADRPI ITMSMAKTGV 
0211 ISRLAGEVFG SAATFGAVKK ASAPGQISVN DLRTVLTILH QA

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             GTTCACATTA TGGACTGGCA AAGATTTCCC 
-070 TCTGGAATAT GTTAAACAGG TCATGGGGTT CGGTGCCTGA CAGGCTGACC GCGTGCAGAA AGGGTAAAAA 
0001 atgaaaaccg taactgtaaa agatctcgtc attggtacgg gcgcacctaa aatcatcgtc tcgctgatgg 
0071 cgaaagatat cgccagcgtg aaatccgaag ctctcgccta tcgtgaagcg gactttgata ttctggaatg 
0141 gcgtgtggac cactatgccg acctctccaa tgtggagtct gtcatggcgg cagcaaaaat tctccgtgag 
0211 accatgccag aaaaaccgct gctgtttacc ttccgcagtg ccaaagaagg cggcgagcag gcgatttcca 
0281 ccgaggctta tattgcactc aatcgtgcag ccatcgacag cggcctggtt gatatgatcg atctggagtt 
0351 atttaccggt gatgatcagg ttaaagaaac cgtcgcctac gcccacgcgc atgatgtgaa agtagtcatg 
0421 tccaaccatg acttccataa aacgccggaa gccgaagaaa tcattgcccg tctgcgcaaa atgcaatcct 
0491 tcgacgccga tattcctaag attgcgctga tgccgcaaag taccagcgat gtgctgacgt tgcttgccgc 
0561 gaccctggag atgcaggagc agtatgccga tcgtccaatt atcacgatgt cgatggcaaa aactggcgta 
0631 atttctcgtc tggctggtga agtatttggc tcggcggcaa cttttggtgc ggtaaaaaaa gcgtctgcgc 
0701 cagggcaaat ctcggtaaat gatttgcgca cggtattaac tattttacac caggcataaG CAATAATATT 
0771 TCGGCGGGAA CACCCTCCCC GCCGAACTAA AAAATATATT CAATCGTATT TAATAAAAAT ATTTCGTGAG 
0841 TCTCTGTGCG CTAATTCTC