|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
Genetika. 1981;17(2):246-57.
[Phenotypic manifestation of the pnd mutation, which promotes purine nucleoside cleavage by Escherichia coli K-12 cells, in the genome of strains defective in the metabolism of nucleic acid precursors]
Kocharian ShM, Kocharian AM.
(
7014363
)
|
|
|
Deletion
|
DE(PLK1608)
,
OCL90-3
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
add
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
add
Search strains by all related name:
add b1623 ECK1618 JW1615 o333
|
General information (Go to Linear View: )
|
|
Gene Name
|
add
|
|
Alternative name
|
b1623,ECK1618,JW1615,o333
|
|
Location, Length
|
1,700,257 - 1,701,258
(
+
)
;
36.65
min
;
1002
(bp) ,
333
(aa)
|
|
Product
|
adenosine deaminase
|
|
Operon Name
|
add
|
|
Note
|
GO_process: GO:0015949 - nucleobase, nucleoside and nucleotide interconversion
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Function
|
enzyme; Salvage of nucleosides and nucleotides
|
|
Gene Ontology
|
GO:0004000
;
adenosine deaminase activity ( add )
GO:0009117
;
nucleotide metabolic process ( add )
GO:0009168
;
purine ribonucleoside monophosphate biosynthetic process ( add )
GO:0016787
;
hydrolase activity ( add )
GO:0019239
;
deaminase activity ( add )
|
|
PID
|
1787910
|
EC number
(KEGG Pathway)
|
3.5.4.4
|
|
SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
ADD_ECOLI
(
P22333
;
P78163; P78240
)
|
|
- Protein name
|
Adenosine deaminase
|
|
- Synonyms
|
EC 3.5.4.4, Adenosine aminohydrolase
|
|
- Gene name
|
Name=add; OrderedLocusNames=b1623;
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Homology Analysis
|
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BLAST
|
|
Bacteria
|
|
GTOP
|
add
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain E, Hiv-1 Tat Protein Derived N-Terminal Nonapeptide Trp2-Tat (1-9) Bound To The Active Site Of Dipeptidyl Peptidase Iv (Cd26)
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Adenosine deaminase
|
|
PSI-BLAST
|
Adenosine deaminase
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
adenosine deaminase [Escherichia coli K12]
|
|
Pfam 28.0
(database updated :
2015-05
)
|
|
Pfam
|
|
|
PROSITE
|
|
PROSITE
|
ASN_GLYCOSYLATION
CK2_PHOSPHO_SITE
MYRISTYL
A_DEAMINASE
|
|
MMBR References
|
Mol Gen Genet. 1975;143(1):85-91.
Location on the chromosome of Escherichia coli of genes governing purine metabolism. Adenosine deaminase (add), guanosine kinase (gsk) and hypoxanthine phosphoribosyltransferase (hpt).
Jochimsen B, Nygaard P, Vestergaard T.
(
765747
)
|
J Bacteriol. 1980;141(1):177-83.
Escherichia coli mutants with altered control of alcohol dehydrogenase and nitrate reductase.
Clark DP, Cronan JE Jr.
(
6986356
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MIDTTLPLTD IHRHLDGNIR PQTILELGRQ YNISLPAQSL ETLIPHVQVI ANEPDLVSFL TKLDWGVKVL
0071 ASLDACRRVA FENIEDAARH GLHYVELRFS PGYMAMAHQL PVAGVVEAVI DGVREGCRTF GVQAKLIGIM
0141 SRTFGEAACQ QELEAFLAHR DQITALDLAG DELGFPGSLF LSHFNRARDA GWHITVHAGE AAGPESIWQA
0211 IRELGAERIG HGVKAIEDRA LMDFLAEQQI GIESCLTSNI QTSTVAELAA HPLKTFLEHG IRASINTDDP
0281 GVQGVDIIHE YTVAAPAAGL SREQIRQAQI NGLEMAFLSA EEKRALREKV AAK
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 CAATTGCGCA ACGTAAAAAA TCGTTGCGCA
-070 ATCGTGGATT TTTACCCTGC TTTGTTTTTA TAATGGTGCG CACTTTTATA TCCAGAAAAA GAGTGCGACC
0001 atgattgata ccaccctgcc attaactgat atccatcgcc accttgatgg caacattcgt ccccagacca
0071 ttcttgaact tggccgccag tataatatct cgcttcctgc acaatccctg gaaacactga ttccccacgt
0141 tcaggtcatt gccaacgaac ccgatctggt gagctttctg accaaacttg actggggcgt taaagttctc
0211 gcctctcttg atgcctgtcg ccgcgtggca tttgaaaaca ttgaagatgc agcccgtcac ggcctgcact
0281 atgtcgagct gcgtttttca ccaggctaca tggcaatggc acatcagctg cctgtagcgg gtgttgtcga
0351 agcggtgatc gatggcgtac gtgaaggttg ccgcaccttt ggtgtgcagg cgaagcttat cggcattatg
0421 agccggacct tcggcgaagc cgcctgtcag caagagctgg aggccttttt agcccaccgt gaccagatta
0491 ccgcacttga tttagccggt gatgaacttg gtttcccggg aagtctgttc ctttctcact tcaaccgcgc
0561 gcgtgatgcg ggctggcata ttaccgtcca tgcaggcgaa gctgccgggc cggaaagcat ctggcaggcg
0631 attcgtgaac tgggtgcgga gcgtattgga catggcgtaa aagccattga agatcgggcg ctgatggatt
0701 ttctcgccga gcaacaaatt ggtattgaat cctgtctgac ctccaatatt cagaccagca ccgtagcaga
0771 gctggctgca catccgctga aaacgttcct tgagcatggc attcgtgcca gcattaacac tgacgatccc
0841 ggcgtacagg gagtggatat cattcacgaa tataccgttg ccgcgccagc tgctgggtta tcccgcgagc
0911 aaatccgcca ggcacagatt aatggtctgg aaatggcttt cctcagcgct gaggaaaaac gcgcactgcg
0981 agaaaaagtc gccgcgaagt aaCAAAATGG ATGGTGCAAA TGCACCATCC ATTTTTCATG CAAGGCACAA
1051 AGTCGCGCGA TGTTTGGCGG ATTCGATGCC CAGCTCAATC AACTCCATTA CC
|
