MG1655
W3110
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Gene Report : malX
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)  
     Deletion DE(PLK1608)  ,  OCL90-3 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  malX
Related strains
     Strains Search Search strains by gene name:  malX   Search strains by all related name:  malX b1621 ECK1616 JW1613

General information  (Go to Linear View:)
 Gene Name malX  
 Alternative name b1621,ECK1616,JW1613  
 Location, Length 1,697,379 - 1,698,971 (  +  ) ;   36.58 min ; 1593 (bp) ,   530 (aa) Go to Linear View
 Product fused maltose and glucose-specific PTS enzymes: IIB component, IIC component  
 Operon Name malXY  
 Note PTS system, maltose and glucose-specific IIABC component; GO_process: GO:0016052 - carbohydrate catabolic process  
 Function transport; Transport of small molecules: Carbohydrates, organic acids, alcohols  
 Gene Ontology GO:0005351 ; sugar:hydrogen ion symporter activity ( malX )
GO:0005886 ; plasma membrane ( malX )
GO:0006810 ; transport ( malX )
GO:0008643 ; carbohydrate transport ( malX )
GO:0008982 ; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity ( malX )
GO:0009401 ; phosphoenolpyruvate-dependent sugar phosphotransferase system ( malX )
GO:0016020 ; membrane ( malX )
GO:0016021 ; integral to membrane ( malX )
GO:0016740 ; transferase activity ( malX )
 PID 1787908  
 EC number
  (KEGG Pathway)
 
2.7.1.69  
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) PTOB_ECOLI ( P19642 ; P77621 )
    -  Protein name PTS system, maltose and glucose-specific IIBC component  
    -  Synonyms Maltose and glucose-permease IIBC component, Phosphotransferase enzyme II, BC component, EC 2.7.1.69  
    -  Gene name Name=malX; OrderedLocusNames=b1621;  

 Linear View (Whole Mode)
View Location
   1685.0  –  1710.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP malX (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain , Glucose Permease  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST PTS system maltose- and glucose-specific EIICB component [Includes: Maltose and glucose permease IIC component  
         PSI-BLAST PTS system maltose- and glucose-specific EIICB component [Includes: Maltose and glucose permease IIC component
    nr     (database updated : 2007.02.20 )
         BLAST fused maltose and glucose-specific PTS enzymes: IIB component -! IIC component [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE GLYCOSAMINOGLYCAN    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    CYSTATIN    PTS_EIIB_CYS     

Other Cross-Reference
    COG COG1263G 
    EcoCyc malX 

MMBR References
J Bacteriol. 1991;173(15):4862-76.
The malX malY operon of Escherichia coli encodes a novel enzyme II of the phosphotransferase system recognizing glucose and maltose and an enzyme abolishing the endogenous induction of the maltose system.
Reidl J, Boos W. ( 1856179 )

Sequences
Amino acid
FASTA format
0001 MTAKTAPKVT LWEFFQQLGK TFMLPVALLS FCGIMLGIGS SLSSHDVITL IPVLGNPVLQ AIFTWMSKIG 
0071 SFAFSFLPVM FCIAIPLGLA RENKGVAAFA GFIGYAVMNL AVNFWLTNKG ILPTTDAAVL KANNIQSILG 
0141 IQSIDTGILG AVIAGIIVWM LHERFHNIRL PDALAFFGGT RFVPIISSLV MGLVGLVIPL VWPIFAMGIS 
0211 GLGHMINSAG DFGPMLFGTG ERLLLPFGLH HILVALIRFT DAGGTQEVCG QTVSGALTIF QAQLSCPTTH 
0281 GFSESATRFL SQGKMPAFLG GLPGAALAMY HCARPENRHK IKGLLISGLI ACVVGGTTEP LEFLFLFVAP 
0351 VLYVIHALLT GLGFTVMSVL GVTIGNTDGN IIDFVVFGIL HGLSTKWYMV PVVAAIWFVV YYVIFRFAIT 
0421 RFNLKTPGRD SEVASSIEKA VAGAPGKSGY NVPAILEALG GADNIVSLDN CITRLRLSVK DMSLVNVQAL 
0491 KDNRAIGVVQ LNQHNLQVVI GPQVQSVKDE MAGLMHTVQA 

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             GTTGCGTAAT GTGATTTATG CCTCACTAAA 
-070 ATTTGATAAA ACGTTTTATC TTCTCGCGCA ATTTACTGAA TCCAGATTGT TCTCTACGAG GAGTCGTTTT 
0001 atgacggcga aaacagcacc gaaagtcacg ctgtgggagt tcttccagca gttaggcaaa accttcatgt 
0071 tacccgtggc attattgtcg ttctgcggca ttatgctcgg cattggtagt tctcttagca gccatgatgt 
0141 cataaccctg atcccggtcc tgggcaaccc cgtgttgcag gctatcttta cctggatgag taagattggc 
0211 tcgtttgctt ttagtttcct gcctgtcatg ttctgtatcg ccatcccgct gggcctggca cgcgaaaata 
0281 aaggcgtagc ggcattcgct ggcttcatcg gttatgcggt aatgaacctc gcggtaaact tctggttgac 
0351 caataaaggc attctgccaa ccacggatgc cgcggttctg aaagccaata acatccagag cattcttggg 
0421 atccagtcga tcgataccgg gatcctcggt gcggtgatcg ccggtattat cgtctggatg ctgcatgagc 
0491 gtttccataa tatccgcctg ccggatgcgc tggcattctt cggcggtacg cgcttcgtac caattatctc 
0561 ctcgctggtg atgggccttg tcggcctggt gattccatta gtctggccga ttttcgccat gggtattagc 
0631 ggcttgggcc atatgataaa cagcgcgggt gatttcggac cgatgctgtt tggtaccggt gaacgtctgc 
0701 tgttgccgtt tggtctgcat cacattctgg tggcattaat tcgctttacc gacgcaggcg gcacgcagga 
0771 agtctgcggt caaaccgtca gcggcgcact gaccatcttc caggcgcaat tgagttgccc gaccactcac 
0841 ggtttttctg aaagcgccac gcgtttcctt tcgcaaggta aaatgcctgc gtttctcggc ggtctgccag 
0911 gtgcagcgtt agctatgtat cactgcgcgc gcccggaaaa tcgccataaa attaaaggtc tgctgatttc 
0981 tggcctgatc gcctgcgtcg ttggcggcac taccgaaccg ctggaattcc tgttcctgtt cgtagcgcca 
1051 gttctgtatg tcatccacgc gctgttaacc ggcctcggct tcaccgtcat gtctgtgctc ggcgtcacca 
1121 tcggtaatac cgacggcaat atcatcgact tcgtggtgtt cggtattttg catggtctgt caaccaagtg 
1191 gtacatggtg ccagtggtgg cggcaatctg gtttgtcgtt tactacgtca tcttccgttt cgctatcacc 
1261 cgcttcaatc tgaaaacccc ggggcgcgat agcgaagttg ccagctcaat cgaaaaagcc gttgccggtg 
1331 cgccgggtaa atcaggttac aacgttcctg caatcctcga agcattaggc ggtgccgaca atattgtcag 
1401 cctcgataac tgcattaccc gtctgcgttt gtctgtgaaa gatatgtcgc ttgttaatgt gcaggcactg 
1471 aaggacaatc gggcaattgg cgtagtacaa cttaatcaac ataacctgca ggttgttatc gggccacaag 
1541 ttcagtcagt aaaagatgaa atggccggtc tgatgcatac tgtccaggca taaGGATAAG ATATGTTCGA 
1611 TTTTTCAAAG GTCGTGGATC GTCATGGCAC ATGGTGTACA CAGTGGGATT ATGTCGCTGA CCGTTTCGGC 
1681 ACTGCTGACC TGT