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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Deletion
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DE(PLK1608)
,
OCL90-2
(D)
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Related gene (W3110 PEC)
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Gene Search
|
Search MG1655 PEC by gene name:
manA
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Related strains
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Strains Search
|
Search strains by gene name:
manA
Search strains by all related name:
manA b1613 ECK1608 JW1605 pmi
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General information (Go to Linear View: )
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Gene Name
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manA
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Alternative name
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b1613,ECK1608,JW1605,pmi
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Location, Length
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1,686,600 - 1,687,775
(
+
)
;
36.35
min
;
1176
(bp) ,
391
(aa)
|
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Product
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mannose-6-phosphate isomerase
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Operon Name
|
manA
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Note
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GO_component: GO:0005737 - cytoplasm; GO_process: GO:0016052 - carbohydrate catabolic process; GO_process: GO:0009226 - nucleotide-sugar biosynthetic process; GO_process: GO:0009242 - colanic acid biosynthetic process; GO_process: GO:0009269 - response to desiccation
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Function
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enzyme; Degradation of small molecules: Carbon compounds
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Gene Ontology
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GO:0004476
;
mannose-6-phosphate isomerase activity ( manA )
GO:0005737
;
cytoplasm ( manA )
GO:0005975
;
carbohydrate metabolic process ( manA )
GO:0008270
;
zinc ion binding ( manA )
GO:0016853
;
isomerase activity ( manA )
GO:0046872
;
metal ion binding ( manA )
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PID
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1787899
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EC number
(KEGG Pathway)
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5.3.1.8
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SWISS-PROT
(
Show details
[
2
more]
)
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Entry name(Acc.no)
|
MANA_ECOLI
(
P00946
)
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- Protein name
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Mannose-6-phosphate isomerase
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- Synonyms
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EC 5.3.1.8, Phosphomannose isomerase, PMI, Phosphohexomutase
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- Gene name
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Name=manA; Synonyms=pmi; OrderedLocusNames=b1613;
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Homology Analysis
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BLAST
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Bacteria
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GTOP
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manA
(
homologous genes of other bacterias
)
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PDB
(database updated :
2007.02.20
)
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PSI-BLAST
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Chain , Phosphomannose Isomerase
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SWISS-PROT
(database updated :
2007.02.20
)
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BLAST
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Mannose-6-phosphate isomerase
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PSI-BLAST
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Mannose-6-phosphate isomerase
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nr
(database updated :
2007.02.20
)
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BLAST
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mannose-6-phosphate isomerase [Escherichia coli K12]
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Pfam 28.0
(database updated :
2015-05
)
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Pfam
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PROSITE
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PROSITE
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PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
MICROBODIES_CTER
PMI_I_1
PMI_I_2
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MMBR References
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Mol Gen Genet. 1975;143(1):85-91.
Location on the chromosome of Escherichia coli of genes governing purine metabolism. Adenosine deaminase (add), guanosine kinase (gsk) and hypoxanthine phosphoribosyltransferase (hpt).
Jochimsen B, Nygaard P, Vestergaard T.
(
765747
)
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Mol Gen Genet. 1980;179(1):49-54.
Characterisation of mutants of Escherichia coli K12, selected by resistance to streptozotocin.
Lengeler J.
(
6450313
)
|
Nucleic Acids Res. 1984;12:3631-3642
Complete nucleotide sequence of the fumarase gene, fumA, of Escherichia coli.
Miles, J. S., and J. R. Guest.
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Gene. 1984;32(1-2):41-8.
Nucleotide sequence and transcriptional start point of the phosphomannose isomerase gene (manA) of Escherichia coli.
Miles JS, Guest JR.
(
6397402
)
|
Mol Gen Genet. 1986;205(2):260-9.
Cloning and complete nucleotide sequence of the Escherichia coli glutamine permease operon (glnHPQ).
Nohno T, Saito T, Hong JS.
(
3027504
)
|
J Bacteriol. 1982;149(2):587-94.
Cloning and endonuclease restriction analysis of uidA and uidR genes in Escherichia coli K-12: determination of transcription direction for the uidA gene.
Blanco C, Ritzenthaler P, Mata-Gilsinger M.
(
6276362
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MQKLINSVQN YAWGSKTALT ELYGMENPSS QPMAELWMGA HPKSSSRVQN AAGDIVSLRD VIESDKSTLL
0071 GEAVAKRFGE LPFLFKVLCA AQPLSIQVHP NKHNSEIGFA KENAAGIPMD AAERNYKDPN HKPELVFALT
0141 PFLAMNAFRE FSEIVSLLQP VAGAHPAIAH FLQQPDAERL SELFASLLNM QGEEKSRALA ILKSALDSQQ
0211 GEPWQTIRLI SEFYPEDSGL FSPLLLNVVK LNPGEAMFLF AETPHAYLQG VALEVMANSD NVLRAGLTPK
0281 YIDIPELVAN VKFEAKPANQ LLTQPVKQGA ELDFPIPVDD FAFSLHDLSD KETTISQQSA AILFCVEGDA
0351 TLWKGSQQLQ LKPGESAFIA ANESPVTVKG HGRLARVYNK L
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 AAACTGAGAC TAGTACGACT TTTTGCGGCT
-070 CCAGGTTACT TCCCGTAGGA TTCTTGCTTT AATAGTGGGA TTAATTTCCA CATTAAAACA GGGATTGATC
0001 atgcaaaaac tcattaactc agtgcaaaac tatgcctggg gcagcaaaac ggcgttgact gaactttatg
0071 gtatggaaaa tccgtccagc cagccgatgg ccgagctgtg gatgggcgca catccgaaaa gcagttcacg
0141 agtgcagaat gccgccggag atatcgtttc actgcgtgat gtgattgaga gtgataaatc gactctgctc
0211 ggagaggccg ttgccaaacg ctttggcgaa ctgcctttcc tgttcaaagt attatgcgca gcacagccac
0281 tctccattca ggttcatcca aacaaacaca attctgaaat cggttttgcc aaagaaaatg ccgcaggtat
0351 cccgatggat gccgccgagc gtaactataa agatcctaac cacaagccgg agctggtttt tgcgctgacg
0421 cctttccttg cgatgaacgc gtttcgtgaa ttttccgaga ttgtctccct actccagccg gtcgcaggtg
0491 cacatccggc gattgctcac tttttacaac agcctgatgc cgaacgttta agcgaactgt tcgccagcct
0561 gttgaatatg cagggtgaag aaaaatcccg cgcgctggcg attttaaaat cggccctcga tagccagcag
0631 ggtgaaccgt ggcaaacgat tcgtttaatt tctgaatttt acccggaaga cagcggtctg ttctccccgc
0701 tattgctgaa tgtggtgaaa ttgaaccctg gcgaagcgat gttcctgttc gctgaaacac cgcacgctta
0771 cctgcaaggc gtggcgctgg aagtgatggc aaactccgat aacgtgctgc gtgcgggtct gacgcctaaa
0841 tacattgata ttccggaact ggttgccaat gtgaaattcg aagccaaacc ggctaaccag ttgttgaccc
0911 agccggtgaa acaaggtgca gaactggact tcccgattcc agtggatgat tttgccttct cgctgcatga
0981 ccttagtgat aaagaaacca ccattagcca gcagagtgcc gccattttgt tctgcgtcga aggcgatgca
1051 acgttgtgga aaggttctca gcagttacag cttaaaccgg gtgaatcagc gtttattgcc gccaacgaat
1121 caccggtgac tgtcaaaggc cacggccgtt tagcgcgtgt ttacaacaag ctgtaaGAGC TTACTGAAAA
1191 AATTAACATC TCTTGCTAAG CTTATTAAAG GCTTATAACA CCTTCAGGCG GCCAGTCCGC CTGATTTCAT
1261 TTTATGGATA ATCATT
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