|
PEC Original Annotations
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|
Essentiality
|
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Class
|
non-essential
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References (PMID)
|
|
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Deletion
|
20
(LD)
,
DE(PLK1608)
,
OCR70,L90-6 (LD 20-1_P/O & 20-2TC)
(D)
|
|
Related gene (W3110 PEC)
|
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Gene Search
|
Search MG1655 PEC by gene name:
hokD
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
hokD
Search strains by all related name:
hokD b1562 ECK1556 JW1554 relF
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General information (Go to Linear View: )
|
|
Gene Name
|
hokD
|
|
Alternative name
|
b1562,ECK1556,JW1554,relF
|
|
Location, Length
|
1,643,143 - 1,643,298
(
-
)
;
35.42
min
;
156
(bp) ,
51
(aa)
|
|
Product
|
Qin prophage; small toxic polypeptide
|
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Operon Name
|
relBE-hokD
|
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Note
|
polypeptide destructive to membrane potential; hokD (relF) regulatory elements are deleted, and the gene is fused to the relBE transcript; evolutionary relic?
|
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Function
|
factor; Cell killing,component of addiction module (incomplete); Phage or Prophage Related
|
|
Gene Ontology
|
GO:0016020
;
membrane ( hokD )
GO:0016021
;
integral to membrane ( hokD )
|
|
PID
|
1787845
|
EC number
(KEGG Pathway)
|
|
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SWISS-PROT
(
Show details
)
|
Entry name(Acc.no)
|
HOKD_ECOLI
(
P07009
;
P77643; Q8X294
)
|
|
- Protein name
|
HokD protein
|
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- Synonyms
|
Protein relF
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- Gene name
|
Name=hokD; Synonyms=relF; OrderedLocusNames=b1562, z3117.1, ECs2754;
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Homology Analysis
|
|
BLAST
|
|
Bacteria
|
|
GTOP
|
hokD
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Protein hokD (Protein relF)
|
|
PSI-BLAST
|
Protein hok
|
|
nr
(database updated :
2007.02.20
)
|
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BLAST
|
putative cell killing protein of prophage [Shigella flexneri 2a str. 2457T]
|
|
Pfam 28.0
(database updated :
2015-05
)
|
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Pfam
|
|
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PROSITE
|
|
PROSITE
|
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
HOK_GEF
|
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MMBR References
|
EMBO J. 1986;5:2023-2029
Mechanism of postreplicational killing by the hok gene product of the parB system of plasmid R1 and its homology with the relF gene product of the E. coli relB operon.
Gerdes, K., F. W. Bech, S. T. Jorgensen, A. Lobner-Olesen, P. B. Rasmussen, T. Atlung, L. Boe, H. O. Karlstrom, S. Molin, and K. von Meyenberg.
|
EMBO J. 1985;4:1059-1066
Sequence of the relB transcription unit from Escherichia coli and identification of the relB gene.
Bech, F. W., S. T. Jorgensen, and B. Diderichsen.
|
| Sequences |
Amino acid
FASTA format
|
0001 MKQQKAMLIA LIVICLTVIV TALVTRKDLC EVRIRTGQTE VAVFTAYEPE E
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 atagcgaggc ggtcaaacgc attctctgaa
-070 ccaaagcatg acatctctgt ttcgcaccga aggtgacact tctgctttgc gttgacagga gaagcaggct
0001 atgaagcagc aaaaggcgat gttaatcgcc ctgatcgtca tctgtttaac cgtcatagtg acggcactgg
0071 taacgaggaa agacctctgc gaggtacgaa tccgaaccgg ccagacggag gtcgctgtct tcacagctta
0141 cgaacctgag gagtaagaga cccggcgggg gagaaatccc tcgccacctc tgatgtggca ggcatcctca
0211 acgcacccgc acttaacccg cttcggcggg tttttgtttt tatttt
|
