MG1655
W3110
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Gene Report : fhuC
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Mol Gen Genet. 1998;258(1-2):156-65.
Transport activity of FhuA, FhuC, FhuD, and FhuB derivatives in a system free of polar effects, and stoichiometry of components involved in ferrichrome uptake.
Mademidis A, Koster W. ( 9613584 )
     Deletion OCR33-15 (D)  ,  OCR33-3 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  fhuC
Related strains
     Strains Search Search strains by gene name:  fhuC   Search strains by all related name:  fhuC b0151 ECK0150 JW0147

General information  (Go to Linear View:)
 Gene Name fhuC  
 Alternative name b0151,ECK0150,JW0147  
 Location, Length 169,778 - 170,575 (  +  ) ;   3.66 min ; 798 (bp) ,   265 (aa) Go to Linear View
 Product iron-hydroxamate transporter subunit  
 Operon Name fhuACDB  
 Note ATP-binding component of hydroxymate-dependent iron transport; GO_component: GO:0005737 - cytoplasm  
 Function transport; Transport of small molecules: Cations  
 Gene Ontology GO:0000166 ; nucleotide binding ( fhuC )
GO:0005506 ; iron ion binding ( fhuC )
GO:0005515 ; protein binding ( fhuC )
GO:0005524 ; ATP binding ( fhuC )
GO:0005886 ; plasma membrane ( fhuC )
GO:0006810 ; transport ( fhuC )
GO:0006811 ; ion transport ( fhuC )
GO:0006826 ; iron ion transport ( fhuC )
GO:0016020 ; membrane ( fhuC )
GO:0016887 ; ATPase activity ( fhuC )
GO:0017111 ; nucleoside-triphosphatase activity ( fhuC )
 PID 1786345  
 EC number
  (KEGG Pathway)
 
 
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) FHUC_ECOLI ( P07821 ; P77548 )
    -  Protein name Ferrichrome transport ATP-binding protein fhuC.  
    -  Synonyms  
    -  Gene name Name=fhuC; OrderedLocusNames=b0151;  

 Linear View (Whole Mode)
View Location
   160.0  –  185.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP fhuC (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Crystal Structure Of The Atp-Binding Cassette Of Multisugar Transporter From Pyrococcus Horikoshii Ot3 Complexed With Atp  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Ferrichrome transport ATP-binding protein fhuC  
         PSI-BLAST Phosphate import ATP-binding protein pstB
    nr     (database updated : 2007.02.20 )
         BLAST iron-hydroxamate transporter subunit [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    ATP_GTP_A    ABC_TRANSPORTER     

Other Cross-Reference
    COG COG1120PH 
    EcoCyc fhuC 

MMBR References
J Bacteriol. 1983;156(3):1301-14.
Cloning and expression of the fhu genes involved in iron(III)-hydroxamate uptake by Escherichia coli.
Fecker L, Braun V. ( 6315685 )
Mol Gen Genet. 1983;192(1-2):131-9.
Plasmid and chromosomal mutants in the iron(III)-aerobactin transport system of Escherichia coli. Use of streptonigrin for selection.
Braun V, Gross R, Koster W, Zimmermann L. ( 6316109 )
Mol Gen Genet. 1987;209(1):49-55.
Nucleotide sequence of the fhuC and fhuD genes involved in iron (III) hydroxamate transport: domains in FhuC homologous to ATP-binding proteins.
Burkhardt R, Braun V. ( 2823072 )
J Bacteriol. 1987;169(8):3844-9.
fhuC and fhuD genes for iron (III)-ferrichrome transport into Escherichia coli K-12.
Coulton JW, Mason P, Allatt DD. ( 3301821 )

Sequences
Amino acid
FASTA format
0001 MQEYTNHSDT TFALRNISFR VPGRTLLHPL SLTFPAGKVT GLIGHNGSGK STLLKMLGRH QPPSEGEILL 
0071 DAQPLESWSS KAFARKVAYL PQQLPPAEGM TVRELVAIGR YPWHGALGRF GAADREKVEE AISLVGLKPL 
0141 AHRLVDSLSG GERQRAWIAM LVAQDSRCLL LDEPTSALDI AHQVDVLSLV HRLSQERGLT VIAVLHDINM 
0211 AARYCDYLVA LRGGEMIAQG TPAEIMRGET LEMIYGIPMG ILPHPAGAAP VSFVY

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             TCTGGGGCGC AGAACGTCAG GTCGTTGCAA 
-070 CCGCAACCTT CCGTTTCTAA TTTCTCTTTT GGGGCACGGA TTTCCGTGCC CATTTCACAA GTTGGCTGTT 
0001 atgcaggaat acacgaatca ttccgatacc acttttgcac tgcgtaatat ctcctttcgt gtgcccgggc 
0071 gcacgctttt gcatccgctg tcgttaacct ttcctgccgg gaaagtgacc ggtctgattg gtcacaacgg 
0141 ttctggtaaa tccactctgc tcaaaatgct tggccgtcat cagccgccgt cggaagggga gattcttctt 
0211 gatgcccaac cgctggaaag ctggagcagc aaagcgtttg cccgcaaagt ggcttatttg ccgcagcagc 
0281 ttcctccggc agaagggatg accgtgcgtg aactggtggc gattggtcgt tacccgtggc atggcgcgct 
0351 ggggcgcttt ggggcggcag atcgcgaaaa agtcgaggaa gctatctcgc tggttggctt aaaaccgctg 
0421 gcgcatcggc tggtcgatag tctctctggc ggcgaacgtc agcgggcgtg gatcgccatg ctggtggcgc 
0491 aggatagccg ttgtctgttg ctcgacgaac cgacctcggc gctggatatc gcccaccagg ttgatgtgct 
0561 gtcgctggtg caccgtttaa gtcaggagcg tggcctgacg gtcattgccg tgttgcacga tatcaatatg 
0631 gcggcacgct actgtgatta tctggtcgcc ctgcgcggcg gtgaaatgat tgctcaggga acgcctgcgg 
0701 aaattatgcg cggcgaaacc ctcgaaatga tttatggcat cccgatgggt attttgccgc atccggcggg 
0771 tgctgcacct gtgagttttg tttattgaTG AGCGGCTTAC CTCTTATTTC GCGCCGTCGA CTGTTAACGG 
0841 CGATGGCGCT TTCTCCGTTG TTATGGCAGA TGAATACCGC CCACGCGGCG GCTATTGA