MG1655
W3110
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Gene Report : marA
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
     Deletion 20 (LD)  ,  DE(PLK1608)  ,  OCR70,L90-6 (LD 20-1_P/O & 20-2TC) (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  marA
Related strains
     Strains Search Search strains by gene name:  marA   Search strains by all related name:  marA b1531 cfxB ECK1524 inaR JW5249 nfxC norB soxQ

General information  (Go to Linear View:)
 Gene Name marA  
 Alternative name b1531,cfxB,ECK1524,inaR,JW5249,nfxC,norB,soxQ  
 Location, Length 1,617,598 - 1,617,981 (  +  ) ;   34.86 min ; 384 (bp) ,   127 (aa) Go to Linear View
 Product DNA-binding transcriptional dual activator of multiple antibiotic resistance  
 Operon Name marRAB  
 Note multiple antibiotic resistance; transcriptional activator of defense systems; GO_component: GO:0005737 - cytoplasm; GO_function: GO:0016563 - transcription activator activity; GO_process: GO:0006350 - transcription; GO_process: GO:0042493 - response to drug; GO_process: GO:0006805 - xenobiotic metabolic process  
 Function regulator; Drug/analog sensitivity  
 Gene Ontology GO:0003677; DNA binding ( marA )
GO:0003700; transcription factor activity ( marA )
GO:0005622; intracellular ( marA )
GO:0006350; transcription ( marA )
GO:0006355; regulation of transcription, DNA-dependent ( marA )
GO:0043565; sequence-specific DNA binding ( marA )
GO:0045449; regulation of transcription ( marA )
GO:0046677; response to antibiotic ( marA )
 PID 87081928  
 EC number
  (KEGG Pathway)
 
 
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) MARR_ECOLI ( P27245 ; P76882; P77582 )
    -  Protein name Multiple antibiotic resistance protein marR.  
    -  Synonyms  
    -  Gene name Name=marR; Synonyms=soxQ, cfxB, inaR; OrderedLocusNames=b1530;  

 Linear View (Whole Mode)
View Location
   1605.0  –  1630.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP marA (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, A Model Of The Ternary Complex Formed Between Mara, The Alpha-Ctd Of Rna Polymerase And Dna  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Multiple antibiotic resistance protein marA  
         PSI-BLAST Multiple antibiotic resistance protein marA
    nr     (database updated : 2007.02.20 )
         BLAST multiple antibiotic resistance [Shigella flexneri 5 str. 8401]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE CAMP_PHOSPHO_SITE    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    TYR_PHOSPHO_SITE    HTH_ARAC_FAMILY_1     

Other Cross-Reference
    EcoCyc marA 

MMBR References
J Bacteriol. 1994;176:143-148
Repressor mutations in the marRAB operon that activate oxidative stress genes and multiple antibiotic resistance in Escherichia coli.
Ariza, R. R., S. P. Cohen, N. Bachhawat, S. B. Levy, and B. Demple.
J Bacteriol. 1993;175:2888-2894
Overexpression of the MarA positive regulator is sufficient to confer multiple antibiotic resistance in Escherichia coli.
Gambino, L., S. J. Gracheck, and P. F. Miller.
J Bacteriol. 1983;155(2):541-8.
Gene in the major cotransduction gap of the Escherichia coli K-12 linkage map required for the expression of chromosomal resistance to tetracycline and other antibiotics.
George AM, Levy SB. ( 6307967 )
Antimicrob Agents Chemother. 1996;40:1266-1269
Multiple antibiotic resistance (mar) locus protects Escherichia coli from rapid cell killing by fluoroquinolones.
Goldman, J. D., D. G. White, and S. B. Levy.
J Bacteriol. 1991;173(14):4433-9.
Activation of oxidative stress genes by mutations at the soxQ/cfxB/marA locus of Escherichia coli.
Greenberg JT, Chou JH, Monach PA, Demple B. ( 1648558 )
J Bacteriol. 1991;173(17):5532-8.
marA, a regulated locus which controls expression of chromosomal multiple antibiotic resistance in Escherichia coli.
Hachler H, Cohen SP, Levy SB. ( 1715857 )
J Mol Evol. 1996;42(4):409-13.
Untranslated sequence upstream of MarA in the multiple antibiotic resistance locus of Escherichia coli is related to the effector-binding domain of the XylS transcriptional activator.
Hachler H, Cohen SP, Levy SB. ( 8642609 )
J Bacteriol. 1995;177:7100-7104
Purification and regulatory properties of MarA protein, a transcriptional activator of Escherichia coli multiple antibiotic and superoxide resistance promoters.
Jair, K. W., R. G. Martin, J. L. Rosner, N. Fujita, A. Ishihama, and R. E. Wolf.
J Bacteriol. 1996;178:2216-2223
Autoactivation of the marRAB multiple antibiotic resistance operon by the MarA transcriptional activator in Escherichia coli.
Martin, R. G., K. W. Jair, R. E. Wolf, and J. L. Rosner.
J Bacteriol. 1994;176:6262-6269
Dual regulation of inaA by the multiple antibiotic resistance (mar) and superoxide (soxRS) stress response systems of Escherichia coli.
Rosner, J. L., and J. L. Slonczewski.
Antimicrob Agents Chemother. 1997;41:2699-2704
Inhibition of the multiple antibiotic resistance (mar) operon in Escherichia coli by antisense DNA analogs.
White, D. G., K. Maneewannakul, E. von Hofe, M. Zillman, W. Eisenberg, A. K. Field, and S. B. Levy.
J Bacteriol. 1992;174:1537-1543
pH dependence and gene structure of inaA in Escherichia coli.
White, S., F. E. Tuttle, D. Blankenhorn, D. C. Dosch, and J. L. Slonczewski.
J Bacteriol. 1993;175:1484-1492
Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli.
Cohen, S. P., H. Hachler, and S. B. Levy.
J Bacteriol. 1988;170(12):5416-22.
marA locus causes decreased expression of OmpF porin in multiple-antibiotic-resistant (Mar) mutants of Escherichia coli.
Cohen SP, McMurry LM, Levy SB. ( 2848006 )

Sequences
Amino acid
FASTA format
0001 MSRRNTDAIT IHSILDWIED NLESPLSLEK VSERSGYSKW HLQRMFKKET GHSLGQYIRS RKMTEIAQKL 
0071 KESNEPILYL AERYGFESQQ TLTRTFKNYF DVPPHKYRMT NMQGESRFLH PLNHYNS

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             CTGCACCAAG AATTAACAAA AAACCTGACG 
-070 GCGGACGAAG TGGCAACACT TGAGTATTTG CTTAAGAAAG TCCTGCCGTA AACAAAAAAG AGGTATGACG 
0001 atgtccagac gcaatactga cgctattacc attcatagca ttttggactg gatcgaggac aacctggaat 
0071 cgccactgtc actggagaaa gtgtcagagc gttcgggtta ctccaaatgg cacctgcaac ggatgtttaa 
0141 aaaagaaacc ggtcattcat taggccaata catccgcagc cgtaagatga cggaaatcgc gcaaaagctg 
0211 aaggaaagta acgagccgat actctatctg gcagaacgat atggcttcga gtcgcaacaa actctgaccc 
0281 gaaccttcaa aaattacttt gatgttccgc cgcataaata ccggatgacc aatatgcagg gcgaatcgcg 
0351 ctttttacat ccattaaatc attacaacag ctagTTGAAA ACGTGACAAC GTCACTGAGG CAATCATGAA 
0421 ACCACTTTCA TCCGCAATAG CAGCTGCGCT TATTCTCTTT TCCGCGCAGG GCGTTGCGGA ACAA