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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Deletion
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20
(LD)
,
OCR70,L90-5 (LD 20-1_P/O)
(D)
,
OCR70,L90-6 (LD 20-1_P/O & 20-2TC)
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
tyrR
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Related strains
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Strains Search
|
Search strains by gene name:
tyrR
Search strains by all related name:
tyrR b1323 ECK1319 JW1316
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General information (Go to Linear View: )
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Gene Name
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tyrR
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Alternative name
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b1323,ECK1319,JW1316
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Location, Length
|
1,384,744 - 1,386,285
(
+
)
;
29.85
min
;
1542
(bp) ,
513
(aa)
|
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Product
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DNA-binding transcriptional dual regulator, tyrosine-binding
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Operon Name
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ycjXF-tyrR
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Note
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transcriptional regulation of aroF, aroG, tyrA and aromatic amino acid transport; GO_component: GO:0005737 - cytoplasm; GO_function: GO:0016563 - transcription activator activity; GO_function: GO:0016564 - transcription repressor activity; GO_process: GO:0006350 - transcription
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Function
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regulator; Transport of small molecules: Amino acids, amines
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Gene Ontology
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GO:0000160
;
two-component signal transduction system (phosphorelay) ( tyrR )
GO:0000166
;
nucleotide binding ( tyrR )
GO:0003677
;
DNA binding ( tyrR )
GO:0004871
;
signal transducer activity ( tyrR )
GO:0005515
;
protein binding ( tyrR )
GO:0005524
;
ATP binding ( tyrR )
GO:0005622
;
intracellular ( tyrR )
GO:0006350
;
transcription ( tyrR )
GO:0006355
;
regulation of transcription, DNA-dependent ( tyrR )
GO:0007165
;
signal transduction ( tyrR )
GO:0008134
;
transcription factor binding ( tyrR )
GO:0008152
;
metabolic process ( tyrR )
GO:0016597
;
amino acid binding ( tyrR )
GO:0017111
;
nucleoside-triphosphatase activity ( tyrR )
GO:0019439
;
aromatic compound catabolic process ( tyrR )
GO:0045449
;
regulation of transcription ( tyrR )
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PID
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1787583
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EC number
(KEGG Pathway)
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|
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Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
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EcoGene
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tyrR
(
EG11042
)
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Number of removed
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0 aa cleaved
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SWISS-PROT
(
Show details
[
2
more]
)
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Entry name(Acc.no)
|
TYRR_ECOLI
(
P07604
)
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- Protein name
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Transcriptional regulatory protein tyrR.
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- Synonyms
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- Gene name
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Name=tyrR; OrderedLocusNames=b1323;
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MMBR References
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J Bacteriol. 1994;176:6921-6930
Regulation of aroL expression by TyrR protein and Trp repressor in Escherichia coli K-12.
Lawley, B., and J. Pittard.
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J Bacteriol. 1971;107(1):8-15.
Regulation of tyrosine biosynthesis in Escherichia coli K-12: isolation and characterization of operator mutants.
Mattern IE, Pittard J.
(
4397929
)
|
Mol Microbiol. 1991;5(7):1585-92.
TyrR protein of Escherichia coli and its role as repressor and activator.
Pittard AJ, Davidson BE.
(
1943694
)
|
J Bacteriol. 1969;97(3):1234-41.
Regulator gene controlling enzymes concerned in tyrosine biosynthesis in Escherichia coli.
Wallace BJ, Pittard J.
(
4887504
)
|
Mol Gen Genet. 1981;181(3):373-8.
D-Amino acid dehydrogenase of Escherichia coli K12: positive selection of mutants defective in enzyme activity and localization of the structural gene.
Wild J, Klopotowski T.
(
6113535
)
|
J Bacteriol. 1993;175:6372-6375
Mutations in the tyrR gene of Escherichia coli which affect TyrR-mediated activation but not TyrR-mediated repression.
Yang, J., H. Camakaris, and A. J. Pittard.
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J Bacteriol. 1993;175:1767-1776
A genetic analysis of various functions of the TyrR protein of Escherichia coli.
Yang, J., S. Ganesan, J. P. Sarsero, and A. J. Pittard.
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J Bacteriol. 1971;108(1):386-99.
Repression of aromatic amino acid biosynthesis in Escherichia coli K-12.
Brown KD, Somerville RL.
(
4399341
)
|
J Bacteriol. 1982;150(1):70-5.
Autoregulation of the tyrR gene.
Camakaris H, Pittard J.
(
6120934
)
|
Mol Gen Genet. 1978;160(2):225-9.
Laboratoire de Chimie Bacterienne C.N.R.S., Marsielle, France.
Chippaux M, Giudici D, Abou-Jaoude A, Casse F, Pascal MC.
(
349355
)
|
J Bacteriol. 1980;144(3):877-83.
Formation of a lambda (Tn10) tyrR+ specialized transducing bacteriophage from Escherichia coli K-12.
Cobbett CS, Pittard J.
(
6254949
)
|
J Bacteriol. 1982;152(3):1276-9.
Cloning and characterization of Escherichia coli K-12 regulator gene tyrR.
Cornish EC, Davidson BE, Pittard J.
(
6754703
)
|
J Biol Chem. 1986;261:403-410
Structure of the Escherichia coli K12 regulatory gene tyrR: nucleotide sequence and sites of initiation of transcription and translation.
Cornish, E. C., V. P. Argyropoulos, J. Pittard, and B. E. Davidson.
|
J Bacteriol. 1992;174(11):3832-3.
Physical map location and transcriptional orientation of the tyrR gene of Escherichia coli K-12.
Cui J, Somerville RL.
(
1592836
)
|
J Bacteriol. 1993;175:1777-1784
A mutational analysis of the structural basis for transcriptional activation and monomer-monomer interaction in the TyrR system of Escherichia coli.
Cui, J., and R. L. Somerville.
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| Sequences |
Amino acid
FASTA format
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0001 MRLEVFCEDR LGLTRELLDL LVLRGIDLRG IEIDPIGRIY LNFAELEFES FSSLMAEIRR IAGVTDVRTV
0071 PWMPSEREHL ALSALLEALP EPVLSVDMKS KVDMANPASC QLFGQKLDRL RNHTAAQLIN GFNFLRWLES
0141 EPQDSHNEHV VINGQNFLME ITPVYLQDEN DQHVLTGAVV MLRSTIRMGR QLQNVAAQDV SAFSQIVAVS
0211 PKMKHVVEQA QKLAMLSAPL LITGDTGTGK DLFAYACHQA SPRAGKPYLA LNCASIPEDA VESELFGHAP
0281 EGKKGFFEQA NGGSVLLDEI GEMSPRMQAK LLRFLNDGTF RRVGEDHEVH VDVRVICATQ KNLVELVQKG
0351 MFREDLYYRL NVLTLNLPPL RDCPQDIMPL TELFVARFAD EQGVPRPKLA ADLNTVLTRY AWPGNVRQLK
0421 NAIYRALTQL DGYELRPQDI LLPDYDAATV AVGEDAMEGS LDEITSRFER SVLTQLYRNY PSTRKLAKRL
0491 GVSHTAIANK LREYGLSQKK NEE
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 TTTCCGTCTT TGTGTCAATG ATTGTTGACA
-070 GAAACCTTCC TGCTATCCAA ATAGTGTCAT ATCATCATAT TAATTGTTCT TTTTTCAGGT GAAGGTTCCC
0001 atgcgtctgg aagtcttttg tgaagaccga ctcggtctga cccgcgaatt actcgatcta ctcgtgctaa
0071 gaggcattga tttacgcggt attgagattg atcccattgg gcgaatctac ctcaattttg ctgaactgga
0141 gtttgagagt ttcagcagtc tgatggccga aatacgccgt attgcgggtg ttaccgatgt gcgtactgtc
0211 ccgtggatgc cttccgaacg tgagcatctg gcgttgagcg cgttactgga ggcgttgcct gaacctgtgc
0281 tctctgtcga tatgaaaagc aaagtggata tggcgaaccc ggcgagctgt cagctttttg ggcaaaaatt
0351 ggatcgcctg cgcaaccata ccgccgcaca attgattaac ggctttaatt ttttacgttg gctggaaagc
0421 gaaccgcaag attcgcataa cgagcatgtc gttattaatg ggcagaattt cctgatggag attacgcctg
0491 tttatcttca ggatgaaaat gatcaacacg tcctgaccgg tgcggtggtg atgttgcgat caacgattcg
0561 tatgggccgc cagttgcaaa atgtcgccgc ccaggacgtc agcgccttca gtcaaattgt cgccgtcagc
0631 ccgaaaatga agcatgttgt cgaacaggcg cagaaactgg cgatgctaag cgcgccgctg ctgattacgg
0701 gtgacacagg tacaggtaaa gatctctttg cctacgcctg ccatcaggca agccccagag cgggcaaacc
0771 ttacctggcg ctgaactgtg cgtctatacc ggaagatgcg gtcgagagtg aactgtttgg tcatgctccg
0841 gaagggaaga aaggattctt tgagcaggcg aacggtggtt cggtgctgtt ggatgaaata ggggaaatgt
0911 caccacggat gcaggcgaaa ttactgcgtt tccttaatga tggcactttc cgtcgggttg gcgaagacca
0981 tgaggtgcat gtcgatgtgc gggtgatttg cgctacgcag aagaatctgg tcgaactggt gcaaaaaggc
1051 atgttccgtg aagatctcta ttatcgtctg aacgtgttga cgctcaatct gccgccgcta cgtgactgtc
1121 cgcaggacat catgccgtta actgagctgt tcgtcgcccg ctttgccgac gagcagggcg tgccgcgtcc
1191 gaaactggcc gctgacctga atactgtact tacgcgttat gcgtggccgg gaaatgtgcg gcagttaaag
1261 aacgctatct atcgcgcact gacacaactg gacggttatg agctgcgtcc acaggatatt ttgttgccgg
1331 attatgacgc cgcaacggta gccgtgggcg aagatgcgat ggaaggttcg ctggacgaaa tcaccagccg
1401 ttttgaacgc tcggtattaa cccagcttta tcgcaattat cccagcacgc gcaaactggc aaaacgtctc
1471 ggcgtttcac ataccgcgat tgccaataag ttgcgggaat atggtctgag tcagaagaag aacgaagagt
1541 aaGCGCGAAT ATGCCTGATG GTGCAACACC ATCAGGCATA TTAAATTATG CTTTCAGTAC AGCCAGAGCT
1611 GCTTCGTAAT CCGGCTCGGT GGTGATTTCA TC
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