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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Deletion
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DE(tonB-cysB)206
,
OCR68,69-1
(D)
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Related gene (W3110 PEC)
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Gene Search
|
Search MG1655 PEC by gene name:
trpE
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Related strains
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Strains Search
|
Search strains by gene name:
trpE
Search strains by all related name:
trpE anth b1264 ECK1258 JW1256 tryD tryp-4
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General information (Go to Linear View: )
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Gene Name
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trpE
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Alternative name
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anth,b1264,ECK1258,JW1256,tryD,tryp-4
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Location, Length
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1,319,408 - 1,320,970
(
-
)
;
28.44
min
;
1563
(bp) ,
520
(aa)
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Product
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component I of anthranilate synthase
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Operon Name
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trpLEDCBA
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Note
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anthranilate synthase component I; GO_process: GO:0000162 - tryptophan biosynthetic process
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Function
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enzyme; Amino acid biosynthesis: Tryptophan
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Gene Ontology
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GO:0000162
;
tryptophan biosynthetic process ( trpE )
GO:0004049
;
anthranilate synthase activity ( trpE )
GO:0008652
;
amino acid biosynthetic process ( trpE )
GO:0009058
;
biosynthetic process ( trpE )
GO:0009073
;
aromatic amino acid family biosynthetic process ( trpE )
GO:0016829
;
lyase activity ( trpE )
GO:0016833
;
oxo-acid-lyase activity ( trpE )
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PID
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1787518
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EC number
(KEGG Pathway)
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4.1.3.27
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Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
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EcoGene
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trpE
(
EG11028
)
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Number of removed
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0 aa cleaved
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SWISS-PROT
(
Show details
[
1
more]
)
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Entry name(Acc.no)
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TRPE_ECOLI
(
P00895
;
P78249
)
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- Protein name
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Anthranilate synthase component I
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- Synonyms
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EC 4.1.3.27
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- Gene name
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Name=trpE; OrderedLocusNames=b1264;
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MMBR References
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Gene. 1980;9(1-2):69-85.
Construction of new cloning vehicles with genes of the tryptophan operon of Escherichia coli as genetic markers.
Enger-Valk BE, Heyneker HL, Oosterbaan RA, Pouwels PH.
(
6247248
)
|
J Mol Biol. 1969;44(1):117-27.
Directed transposition of the arabinose operon: a technique for the isolation of specialized transducing bacteriophages for any Escherichia coli gene.
Gottesman S, Beckwith JR.
(
4897798
)
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J Bacteriol. 1970;101(1):209-17.
Mechanism of 3-methylanthranilic acid derepression of the tryptophan operon in Escherichia coli.
Held WA, Smith OH.
(
4904235
)
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J Mol Biol. 1969;39(1):159-79.
Operator mutants of the tryptophan operon in Escherichia coli.
Hiraga S.
(
4938813
)
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J Bacteriol. 1971;107(1):8-15.
Regulation of tyrosine biosynthesis in Escherichia coli K-12: isolation and characterization of operator mutants.
Mattern IE, Pittard J.
(
4397929
)
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J Biol Chem. 1960;235:1098-102.
False feedback inhibition: inhibition of tryptophan biosynthesis by 5-methyltryptophan.
Moyed HS.
(
14424820
)
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J Mol Biol. 1980;142(4):503-17.
Nucleotide sequences of the trpG regions of Escherichia coli, Shigella dysenteriae, Salmonella typhimurium and Serratia marcescens.
Nichols BP, Miozzari GF, van Cleemput M, Bennett GN, Yanofsky C.
(
7007652
)
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J Mol Biol. 1981;146(1):45-54.
Nucleotide sequence of Escherichia coli trpE. Anthranilate synthetase component I contains no tryptophan residues.
Nichols BP, van Cleemput M, Yanofsky C.
(
7021857
)
|
Proc Natl Acad Sci U S A. 1979;76:5524-5528
Attenuation in the Escherichia coli tryptophan operon: role of RNA secondary structure involving the tryptophan codon region.
Oxender, D. L., G. Zurawski, and C. Yanofsky.
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Nucleic Acids Res. 1981;9:6647-6668
The complete nucleotide sequence of the tryptophan operon of E. coli.
Yanofsky, C., T. Platt, I. P. Crawford, B. Nichols, G. E. Christie, H. Horowitz, M. VanCleemput, and A. M. Wu.
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| Sequences |
Amino acid
FASTA format
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0001 MQTQKPTLEL LTCEGAYRDN PTALFHQLCG DRPATLLLES ADIDSKDDLK SLLLVDSALR ITALGDTVTI
0071 QALSGNGEAL LALLDNALPA GVESEQSPNC RVLRFPPVSP LLDEDARLCS LSVFDAFRLL QNLLNVPKEE
0141 REAMFFGGLF SYDLVAGFED LPQLSAENNC PDFCFYLAET LMVIDHQKKS TRIQASLFAP NEEEKQRLTA
0211 RLNELRQQLT EAAPPLPVVS VPHMRCECNQ SDEEFGGVVR LLQKAIRAGE IFQVVPSRRF SLPCPSPLAA
0281 YYVLKKSNPS PYMFFMQDND FTLFGASPES SLKYDATSRQ IEIYPIAGTR PRGRRADGSL DRDLDSRIEL
0351 EMRTDHKELS EHLMLVDLAR NDLARICTPG SRYVADLTKV DRYSYVMHLV SRVVGELRHD LDALHAYRAC
0421 MNMGTLSGAP KVRAMQLIAE AEGRRRGSYG GAVGYFTAHG DLDTCIVIRS ALVENGIATV QAGAGVVLDS
0491 VPQSEADETR NKARAVLRAI ATAHHAQETF
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 acttcctgaa acgggcagtg tattcaccat
-070 gcgtaaagca atcagatacc cagcccgcct aatgagcggg cttttttttg aacaaaatta gagaataaca
0001 atgcaaacac aaaaaccgac tctcgaactg ctaacctgcg aaggcgctta tcgcgacaat cccaccgcgc
0071 tttttcacca gttgtgtggg gatcgtccgg caacgctgct gctggaatcc gcagatatcg acagcaaaga
0141 tgatttaaaa agcctgctgc tggtagacag tgcgctgcgc attacagctt taggtgacac tgtcacaatc
0211 caggcacttt ccggcaacgg cgaagccctc ctggcactac tggataacgc cctgcctgcg ggtgtggaaa
0281 gtgaacaatc accaaactgc cgtgtgctgc gcttcccccc tgtcagtcca ctgctggatg aagacgcccg
0351 cttatgctcc ctttcggttt ttgacgcttt ccgtttattg cagaatctgt tgaatgtacc gaaggaagaa
0421 cgagaagcca tgttcttcgg cggcctgttc tcttatgacc ttgtggcggg atttgaagat ttaccgcaac
0491 tgtcagcgga aaataactgc cctgatttct gtttttatct cgctgaaacg ctgatggtga ttgaccatca
0561 gaaaaaaagc acccgtattc aggccagcct gtttgctccg aatgaagaag aaaaacaacg tctcactgct
0631 cgcctgaacg aactacgtca gcaactgacc gaagccgcgc cgccgctgcc agtggtttcc gtgccgcata
0701 tgcgttgtga atgtaatcag agcgatgaag agttcggtgg cgtagtgcgt ttgttgcaaa aagcgattcg
0771 cgctggagaa attttccagg tggtgccatc tcgccgtttc tctctgccct gcccgtcacc gctggcggcc
0841 tattacgtgc tgaaaaagag taatcccagc ccgtacatgt tttttatgca ggataatgat ttcaccctat
0911 ttggcgcgtc gccggaaagc tcgctcaagt atgatgccac cagccgccag attgagatct acccgattgc
0981 cggaacacgc ccacgcggtc gtcgcgccga tggttcactg gacagagatc tcgacagccg tattgaactg
1051 gaaatgcgta ccgatcataa agagctgtct gaacatctga tgctggttga tctcgcccgt aatgatctgg
1121 cacgcatttg cacccccggc agccgctacg tcgccgatct caccaaagtt gaccgttatt cctatgtgat
1191 gcacctcgtc tctcgcgtag tcggcgaact gcgtcacgat cttgacgccc tgcacgctta tcgcgcctgt
1261 atgaatatgg ggacgttaag cggtgcgccg aaagtacgcg ctatgcagtt aattgccgag gcggaaggtc
1331 gtcgccgcgg cagctacggc ggcgcggtag gttatttcac cgcgcatggc gatctcgaca cctgcattgt
1401 gatccgctcg gcgctggtgg aaaacggtat cgccaccgtg caagcgggtg ctggtgtagt ccttgattct
1471 gttccgcagt cggaagccga cgaaacccgt aacaaagccc gcgctgtact gcgcgctatt gccaccgcgc
1541 atcatgcaca ggagactttc tgatggctga cattctgctg ctcgataata tcgactcttt tacgtacaac
1611 ctggcagatc agttgcgcag caatgggcat aacgtggtga tttaccgcaa cca
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