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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Deletion
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DE(tonB-cysB)206
,
OCR68,69-1
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
trpD
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Related strains
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Strains Search
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Search strains by gene name:
trpD
Search strains by all related name:
trpD b1263 ECK1257 JW1255 trpGD
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General information (Go to Linear View: )
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Gene Name
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trpD
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Alternative name
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b1263,ECK1257,JW1255,trpGD
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Location, Length
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1,317,813 - 1,319,408
(
-
)
;
28.40
min
;
1596
(bp) ,
531
(aa)
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Product
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fused glutamine amidotransferase (component II)of anthranilate synthase/anthranilate phosphoribosyl transferase
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Operon Name
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trpLEDCBA
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Note
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anthranilate synthase component II, glutamine amidotransferase and phosphoribosylanthranilate transferase; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0000162 - tryptophan biosynthetic process
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Function
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enzyme; Amino acid biosynthesis: Tryptophan
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Gene Ontology
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GO:0000162
;
tryptophan biosynthetic process ( trpD )
GO:0003824
;
catalytic activity ( trpD )
GO:0004048
;
anthranilate phosphoribosyltransferase activity ( trpD )
GO:0004049
;
anthranilate synthase activity ( trpD )
GO:0006541
;
glutamine metabolic process ( trpD )
GO:0008152
;
metabolic process ( trpD )
GO:0008652
;
amino acid biosynthetic process ( trpD )
GO:0009058
;
biosynthetic process ( trpD )
GO:0009073
;
aromatic amino acid family biosynthetic process ( trpD )
GO:0016740
;
transferase activity ( trpD )
GO:0016757
;
transferase activity, transferring glycosyl groups ( trpD )
GO:0016829
;
lyase activity ( trpD )
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PID
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1787517
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EC number
(KEGG Pathway)
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2.4.2.18
4.1.3.27
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Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
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EcoGene
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trpD
(
EG11027
)
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Number of removed
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1 aa cleaved
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SWISS-PROT
(
Show details
[
2
more]
)
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Entry name(Acc.no)
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TRPG_ECOLI
(
P00904
;
P76833; P76835; P78302
)
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- Protein name
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Anthranilate synthase component II
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- Synonyms
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EC 4.1.3.27
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- Gene name
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Name=trpD; Synonyms=trpGD; OrderedLocusNames=b1263;
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MMBR References
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Gene. 1980;9(1-2):69-85.
Construction of new cloning vehicles with genes of the tryptophan operon of Escherichia coli as genetic markers.
Enger-Valk BE, Heyneker HL, Oosterbaan RA, Pouwels PH.
(
6247248
)
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J Mol Biol. 1969;44(1):117-27.
Directed transposition of the arabinose operon: a technique for the isolation of specialized transducing bacteriophages for any Escherichia coli gene.
Gottesman S, Beckwith JR.
(
4897798
)
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J Mol Biol. 1969;39(1):159-79.
Operator mutants of the tryptophan operon in Escherichia coli.
Hiraga S.
(
4938813
)
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J Mol Biol. 1982;156(2):245-56.
Nucleotide sequence of the trpD gene, encoding anthranilate synthetase component II of Escherichia coli.
Horowitz H, Christie GE, Platt T.
(
6283099
)
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J Mol Biol. 1982;156(2):257-67.
Identification of trp-p2, an internal promoter in the tryptophan operon of Escherichia coli.
Horowitz H, Platt T.
(
7045383
)
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J Bacteriol. 1971;107(1):8-15.
Regulation of tyrosine biosynthesis in Escherichia coli K-12: isolation and characterization of operator mutants.
Mattern IE, Pittard J.
(
4397929
)
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J Mol Biol. 1980;142(4):503-17.
Nucleotide sequences of the trpG regions of Escherichia coli, Shigella dysenteriae, Salmonella typhimurium and Serratia marcescens.
Nichols BP, Miozzari GF, van Cleemput M, Bennett GN, Yanofsky C.
(
7007652
)
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Nucleic Acids Res. 1981;9:6647-6668
The complete nucleotide sequence of the tryptophan operon of E. coli.
Yanofsky, C., T. Platt, I. P. Crawford, B. Nichols, G. E. Christie, H. Horowitz, M. VanCleemput, and A. M. Wu.
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| Sequences |
Amino acid
FASTA format
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0001 MADILLLDNI DSFTYNLADQ LRSNGHNVVI YRNHIPAQTL IERLATMSNP VLMLSPGPGV PSEAGCMPEL
0071 LTRLRGKLPI IGICLGHQAI VEAYGGYVGQ AGEILHGKAS SIEHDGQAMF AGLTNPLPVA RYHSLVGSNI
0141 PAGLTINAHF NGMVMAVRHD ADRVCGFQFH PESILTTQGA RLLEQTLAWA QQKLEPANTL QPILEKLYQA
0211 QTLSQQESHQ LFSAVVRGEL KPEQLAAALV SMKIRGEHPN EIAGAATALL ENAAPFPRPD YLFADIVGTG
0281 GDGSNSINIS TASAFVAAAC GLKVAKHGNR SVSSKSGSSD LLAAFGINLD MNADKSRQAL DELGVCFLFA
0351 PKYHTGFRHA MPVRQQLKTR TLFNVLGPLI NPAHPPLALI GVYSPELVLP IAETLRVLGY QRAAVVHSGG
0421 MDEVSLHAPT IVAELHDGEI KSYQLTAEDF GLTPYHQEQL AGGTPEENRD ILTRLLQGKG DAAHEAAVAA
0491 NVAMLMRLHG HEDLQANAQT VLEVLRSGSA YDRVTALAAR G
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Nucleotide
FASTA format
View sequence out neighbor 100bp
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-100 ttgattctgt tccgcagtcg gaagccgacg
-070 aaacccgtaa caaagcccgc gctgtactgc gcgctattgc caccgcgcat catgcacagg agactttctg
0001 atggctgaca ttctgctgct cgataatatc gactctttta cgtacaacct ggcagatcag ttgcgcagca
0071 atgggcataa cgtggtgatt taccgcaacc atattccggc gcaaacctta attgaacgcc tggcgaccat
0141 gagcaatccg gtgctgatgc tttctcctgg ccccggtgtg ccgagcgaag ccggttgtat gccggaactc
0211 ctcacccgct tgcgtggcaa gctgcccatt attggcattt gcctcggaca tcaggcgatt gtcgaagctt
0281 acgggggcta tgtcggtcag gcgggcgaaa ttctccacgg taaagcctcc agcattgaac atgacggtca
0351 ggcgatgttt gccggattaa caaacccgct gccggtggcg cgttatcact cgctggttgg cagtaacatt
0421 ccggccggtt taaccatcaa cgcccatttt aatggcatgg tgatggcagt acgtcacgat gcggatcgcg
0491 tttgtggatt ccagttccat ccggaatcca ttctcaccac ccagggcgct cgcctgctgg aacaaacgct
0561 ggcctgggcg cagcagaaac tagagccagc caacacgctg caaccgattc tggaaaaact gtatcaggcg
0631 cagacgctta gccaacaaga aagccaccag ctgttttcag cggtggtgcg tggcgagctg aagccggaac
0701 aactggcggc ggcgctggtg agcatgaaaa ttcgcggtga gcacccgaac gagatcgccg gggcagcaac
0771 cgcgctactg gaaaacgcag cgccgttccc gcgcccggat tatctgtttg ctgatatcgt cggtactggc
0841 ggtgacggca gcaacagtat caatatttct accgccagtg cgtttgtcgc cgcggcctgt gggctgaaag
0911 tggcgaaaca cggcaaccgt agcgtctcca gtaaatctgg ttcgtccgat ctgctggcgg cgttcggtat
0981 taatcttgat atgaacgccg ataaatcgcg ccaggcgctg gatgagttag gtgtatgttt cctctttgcg
1051 ccgaagtatc acaccggatt ccgccacgcg atgccggttc gccagcaact gaaaacccgc accctgttca
1121 atgtgctggg gccattgatt aacccggcgc atccgccgct ggcgttaatt ggtgtttata gtccggaact
1191 ggtgctgccg attgccgaaa ccttgcgcgt gctggggtat caacgcgcgg cggtggtgca cagcggcggg
1261 atggatgaag tttcattaca cgcgccgaca atcgttgccg aactgcatga cggcgaaatt aaaagctatc
1331 agctcaccgc agaagacttt ggcctgacac cctaccacca ggagcaactg gcaggcggaa caccggaaga
1401 aaaccgtgac attttaacac gtttgttaca aggtaaaggc gacgccgccc atgaagcagc cgtcgctgcg
1471 aacgtcgcca tgttaatgcg cctgcatggc catgaagatc tgcaagccaa tgcgcaaacc gttcttgagg
1541 tactgcgcag tggttccgct tacgacagag tcaccgcact ggcggcacga gggtaaatga tgcaaaccgt
1611 tttagcgaaa atcgtcgcag acaaggcgat ttgggtagaa gcccgcaaac agcagcaacc gctggccagt
1681 tttcagaatg aggttc
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