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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Protein Sci. 1998;7(5):1221-32.
Mutational analysis of the active site of indoleglycerol phosphate synthase from Escherichia coli.
Darimont B, Stehlin C, Szadkowski H, Kirschner K.
(
9605328
)
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Deletion
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DE(tonB-cysB)206
,
OCR68,69-1
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
trpC
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Related strains
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Strains Search
|
Search strains by gene name:
trpC
Search strains by all related name:
trpC b1262 ECK1256 JW1254 trpF
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General information (Go to Linear View: )
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Gene Name
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trpC
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Alternative name
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b1262,ECK1256,JW1254,trpF
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Location, Length
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1,316,451 - 1,317,809
(
-
)
;
28.37
min
;
1359
(bp) ,
452
(aa)
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Product
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fused indole-3-glycerolphosphatesynthetase/N-(5-phosphoribosyl)anthranilate isomerase
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Operon Name
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trpLEDCBA
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Note
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N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0000162 - tryptophan biosynthetic process
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Function
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enzyme; Amino acid biosynthesis: Tryptophan
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Gene Ontology
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GO:0000162
;
tryptophan biosynthetic process ( trpC )
GO:0003824
;
catalytic activity ( trpC )
GO:0004425
;
indole-3-glycerol-phosphate synthase activity ( trpC )
GO:0004640
;
phosphoribosylanthranilate isomerase activity ( trpC )
GO:0006568
;
tryptophan metabolic process ( trpC )
GO:0008152
;
metabolic process ( trpC )
GO:0008652
;
amino acid biosynthetic process ( trpC )
GO:0009073
;
aromatic amino acid family biosynthetic process ( trpC )
GO:0016829
;
lyase activity ( trpC )
GO:0016831
;
carboxy-lyase activity ( trpC )
GO:0016853
;
isomerase activity ( trpC )
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PID
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87081863
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EC number
(KEGG Pathway)
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4.1.1.48
5.3.1.24
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SWISS-PROT
(
Show details
[
1
more]
)
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Entry name(Acc.no)
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TRPC_ECOLI
(
P00909
;
P78059; P78234; P94704
)
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- Protein name
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Tryptophan biosynthesis protein trpCF
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- Synonyms
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- Gene name
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Name=trpC; OrderedLocusNames=b1262;
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MMBR References
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Gene. 1980;9(1-2):69-85.
Construction of new cloning vehicles with genes of the tryptophan operon of Escherichia coli as genetic markers.
Enger-Valk BE, Heyneker HL, Oosterbaan RA, Pouwels PH.
(
6247248
)
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J Mol Biol. 1969;44(1):117-27.
Directed transposition of the arabinose operon: a technique for the isolation of specialized transducing bacteriophages for any Escherichia coli gene.
Gottesman S, Beckwith JR.
(
4897798
)
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J Mol Biol. 1969;39(1):159-79.
Operator mutants of the tryptophan operon in Escherichia coli.
Hiraga S.
(
4938813
)
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J Mol Biol. 1982;156(2):257-67.
Identification of trp-p2, an internal promoter in the tryptophan operon of Escherichia coli.
Horowitz H, Platt T.
(
7045383
)
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J Bacteriol. 1971;107(1):8-15.
Regulation of tyrosine biosynthesis in Escherichia coli K-12: isolation and characterization of operator mutants.
Mattern IE, Pittard J.
(
4397929
)
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Nucleic Acids Res. 1981;9:6647-6668
The complete nucleotide sequence of the tryptophan operon of E. coli.
Yanofsky, C., T. Platt, I. P. Crawford, B. Nichols, G. E. Christie, H. Horowitz, M. VanCleemput, and A. M. Wu.
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J Mol Biol. 1980;142(4):519-30.
Gene structure in the tryptophan operon of Escherichia coli. Nucleotide sequence of trpC and the flanking intercistronic regions.
Christie GE, Platt T.
(
7007653
)
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| Sequences |
Amino acid
FASTA format
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0001 MQTVLAKIVA DKAIWVEARK QQQPLASFQN EVQPSTRHFY DALQGARTAF ILECKKASPS KGVIRDDFDP
0071 ARIAAIYKHY ASAISVLTDE KYFQGSFNFL PIVSQIAPQP ILCKDFIIDP YQIYLARYYQ ADACLLMLSV
0141 LDDDQYRQLA AVAHSLEMGV LTEVSNEEEQ ERAIALGAKV VGINNRDLRD LSIDLNRTRE LAPKLGHNVT
0211 VISESGINTY AQVRELSHFA NGFLIGSALM AHDDLHAAVR RVLLGENKVC GLTRGQDAKA AYDAGAIYGG
0281 LIFVATSPRC VNVEQAQEVM AAAPLQYVGV FRNHDIADVV DKAKVLSLAA VQLHGNEEQL YIDTLREALP
0351 AHVAIWKALS VGETLPAREF QHVDKYVLDN GQGGSGQRFD WSLLNGQSLG NVLLAGGLGA DNCVEAAQTG
0421 CAGLDFNSAV ESQPGIKDAR LLASVFQTLR AY
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 ccatgaagat ctgcaagcca atgcgcaaac
-070 cgttcttgag gtactgcgca gtggttccgc ttacgacaga gtcaccgcac tggcggcacg agggtaaatg
0001 atgcaaaccg ttttagcgaa aatcgtcgca gacaaggcga tttgggtaga agcccgcaaa cagcagcaac
0071 cgctggccag ttttcagaat gaggttcagc cgagcacgcg acatttttat gatgcgctac agggtgcgcg
0141 cacggcgttt attctggagt gcaagaaagc gtcgccgtca aaaggcgtga tccgtgatga tttcgatcca
0211 gcacgcattg ccgccattta taaacattac gcttcggcaa tttcggtgct gactgatgag aaatattttc
0281 aggggagctt taatttcctc cccatcgtca gccaaatcgc cccgcagccg attttatgta aagacttcat
0351 tatcgaccct taccagatct atctggcgcg ctattaccag gccgatgcct gcttattaat gctttcagta
0421 ctggatgacg accaatatcg ccagcttgcc gccgtcgctc acagtctgga gatgggggtg ctgaccgaag
0491 tcagtaatga agaggaacag gagcgcgcca ttgcattggg agcaaaggtc gttggcatca acaaccgcga
0561 tctgcgtgat ttgtcgattg atctcaaccg tacccgcgag cttgcgccga aactggggca caacgtgacg
0631 gtaatcagcg aatccggcat caatacttac gctcaggtgc gcgagttaag ccacttcgct aacggttttc
0701 tgattggttc ggcgttgatg gcccatgacg atttgcacgc cgccgtgcgc cgggtgttgc tgggtgagaa
0771 taaagtatgt ggcctgacgc gtgggcaaga tgctaaagca gcttatgacg cgggcgcgat ttacggtggg
0841 ttgatttttg ttgcgacatc accgcgttgc gtcaacgttg aacaggcgca ggaagtgatg gctgcggcac
0911 cgttgcagta tgttggcgtg ttccgcaatc acgatattgc cgatgtggtg gacaaagcta aggtgttatc
0981 gctggcggca gtgcaactgc atggtaatga agaacagctg tatatcgata cgctgcgtga agctctgcca
1051 gcacatgttg ccatctggaa agcattaagc gtcggtgaaa ccctgcccgc ccgcgagttt cagcacgttg
1121 ataaatatgt tttagacaac ggccagggtg gaagcgggca acgttttgac tggtcactat taaatggtca
1191 atcgcttggc aacgttctgc tggcgggggg cttaggcgca gataactgcg tggaagcggc acaaaccggc
1261 tgcgccggac ttgattttaa ttctgctgta gagtcgcaac cgggcatcaa agacgcacgt cttttggcct
1331 cggttttcca gacgctgcgc gcatattaag gaaaggaaca atgacaacat tacttaaccc ctattttggt
1401 gagtttggcg gcatgtacgt gccacaaatc ctgatgcctg ctctgcgcca gctggaaga
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