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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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J Biol Chem. 1992;267(9):5751-4.
The gene encoding Escherichia coli acyl carrier protein lies within a cluster of fatty acid biosynthetic genes.
Rawlings M, Cronan JE Jr.
(
1556094
)
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Deletion
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
fabF
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Related strains
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Strains Search
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Search strains by gene name:
fabF
Search strains by all related name:
fabF b1095 ctr cvc ECK1081 fabJ JW1081 vtr
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General information (Go to Linear View: )
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Gene Name
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fabF
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Alternative name
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b1095,ctr,cvc,ECK1081,fabJ,JW1081,vtr
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Location, Length
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1,151,162 - 1,152,403
(
+
)
;
24.81
min
;
1242
(bp) ,
413
(aa)
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Product
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3-oxoacyl-[acyl-carrier-protein] synthase II
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Operon Name
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yceD-rpmF-plsX-fabHDG-acpP-fabF
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Note
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GO_component: GO:0005737 - cytoplasm
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Function
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enzyme; Fatty acid and phosphatidic acid biosynthesis
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Gene Ontology
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GO:0003824
;
catalytic activity ( fabF )
GO:0004315
;
3-oxoacyl-[acyl-carrier-protein] synthase activity ( fabF )
GO:0005515
;
protein binding ( fabF )
GO:0006633
;
fatty acid biosynthetic process ( fabF )
GO:0008152
;
metabolic process ( fabF )
GO:0008415
;
acyltransferase activity ( fabF )
GO:0008610
;
lipid biosynthetic process ( fabF )
GO:0009058
;
biosynthetic process ( fabF )
GO:0016740
;
transferase activity ( fabF )
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PID
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1787337
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EC number
(KEGG Pathway)
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2.3.1.41
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Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
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EcoGene
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fabF
(
EG12606
)
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Number of removed
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1 aa cleaved
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SWISS-PROT
(
Show details
)
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Entry name(Acc.no)
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FABF_ECOLI
(
P39435
)
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- Protein name
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3-oxoacyl-[acyl-carrier-protein] synthase II
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- Synonyms
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EC 2.3.1.41, Beta- ketoacyl-ACP synthase II, KAS II
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- Gene name
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OrderedLocusNames=b1095, c1365, z1734, ECs1473, SF1099, S1179;
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MMBR References
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J Biol Chem. 1980;255:3263-3265
β-Ketoacyl-acyl carrier protein synthase II of Escherichia coli. Evidence for function in the thermal regulation of fatty acid synthesis.
Garwin, J. L., A. L. Klages, and J. E. Cronan, Jr.
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J Biol Chem. 1980;255:11949-11956
Structural, enzymatic, and genetic studies of beta-ketoacylacyl carrier protein synthases I and II of Escherichia coli.
Garwin, J. L., A. L. Klages, and J. E. Cronan, Jr.
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J Biol Chem. 1992;267:5751-5754
The gene encoding Escherichia coli acyl carrier protein lies within a cluster of fatty acid biosynthetic genes.
Rawlings, M., and J. E. Cronan, Jr.
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Proc Natl Acad Sci U S A. 1994;91:11027-11031
The fabJ-encoded beta-ketoacyl substrates.
Siggard-Andersen, M., M. Wissenbach, J.-A. Chuck, I. Svendsen, J. G. Olsen, and P. von Wettstein-Knowles.
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J Bacteriol. 1983;154(1):221-30.
Genetic and biochemical analyses of Escherichia coli mutants altered in the temperature-dependent regulation of membrane lipid composition.
Ulrich AK, de Mendoza D, Garwin JL, Cronan JE Jr.
(
6339472
)
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| Sequences |
Amino acid
FASTA format
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0001 MSKRRVVVTG LGMLSPVGNT VESTWKALLA GQSGISLIDH FDTSAYATKF AGLVKDFNCE DIISRKEQRK
0071 MDAFIQYGIV AGVQAMQDSG LEITEENATR IGAAIGSGIG GLGLIEENHT SLMNGGPRKI SPFFVPSTIV
0141 NMVAGHLTIM YGLRGPSISI ATACTSGVHN IGHAARIIAY GDADVMVAGG AEKASTPLGV GGFGAARALS
0211 TRNDNPQAAS RPWDKERDGF VLGDGAGMLV LEEYEHAKKR GAKIYAELVG FGMSSDAYHM TSPPENGAGA
0281 ALAMANALRD AGIEASQIGY VNAHGTSTPA GDKAEAQAVK TIFGEAASRV LVSSTKSMTG HLLGAAGAVE
0351 SIYSILALRD QAVPPTINLD NPDEGCDLDF VPHEARQVSG MEYTLCNSFG FGGTNGSLIF KKI
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 CCACCAGGCG TAAGTGAACA TCTCCAGGCG
-070 GTCGTTCGAC CGCCTGAGTT TTATCTTTTT GTCCCACTAG AATCATTTTT TCCCTCCCTG GAGGACAAAC
0001 gtgtctaagc gtcgtgtagt tgtgaccgga ctgggcatgt tgtctcctgt cggcaatacc gtagagtcta
0071 cctggaaagc tctgcttgcc ggtcagagtg gcatcagcct aatcgaccat ttcgatacta gcgcctatgc
0141 aacgaaattt gctggcttag taaaggattt taactgtgag gacattatct cgcgcaaaga acagcgcaag
0211 atggatgcct tcattcaata tggaattgtc gctggcgttc aggccatgca ggattctggc cttgaaataa
0281 cggaagagaa cgcaacccgc attggtgccg caattggctc cgggattggc ggcctcggac tgatcgaaga
0351 aaaccacaca tctctgatga acggtggtcc acgtaagatc agcccattct tcgttccgtc aacgattgtg
0421 aacatggtgg caggtcatct gactatcatg tatggcctgc gtggcccgag catctctatc gcgactgcct
0491 gtacttccgg cgtgcacaac attggccatg ctgcgcgtat tatcgcgtat ggcgatgctg acgtgatggt
0561 tgcaggtggc gcagagaaag ccagtacgcc gctgggcgtt ggtggttttg gcgcggcacg tgcattatct
0631 acccgcaatg ataacccgca agcggcgagc cgcccgtggg ataaagagcg tgatggtttc gtactgggcg
0701 atggtgccgg tatgctggta cttgaagagt acgaacacgc gaaaaaacgc ggtgcgaaaa tttacgctga
0771 actcgtcggc tttggtatga gcagcgatgc ttatcatatg acgtcaccgc cagaaaatgg cgcaggcgca
0841 gctctggcga tggcaaatgc tctgcgtgat gcaggcattg aagcgagtca gattggctac gttaacgcgc
0911 acggtacttc tacgccggct ggcgataaag ctgaagcgca ggcggtgaaa accatcttcg gtgaagctgc
0981 aagccgtgtg ttggtaagct ccacgaaatc tatgaccggt cacctgttag gtgcggcggg tgcagtagaa
1051 tctatctact ccatcctggc gctgcgcgat caggctgttc cgccaaccat caacctggat aacccggatg
1121 aaggttgcga tctggatttc gtaccgcacg aagcgcgtca ggttagcgga atggaataca ctctgtgtaa
1191 ctccttcggc ttcggtggca ctaatggttc tttgatcttt aaaaagatct aaGTTGTCAT TTTCCACCCT
1261 TATAAAAGGT CCGCTTGCGG GCCTTTTTTC TTAGCTTTTA TTCCGACTTG TTCCGTAGTG AACATGCTGC
1331 CACACTAACA AT
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