|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
essential
|
|
References (PMID)
|
J Bacteriol. 1993;175(21):6881-9.
Organization and nucleotide sequences of the genes encoding the biotin carboxyl carrier protein and biotin carboxylase protein of Pseudomonas aeruginosa acetyl coenzyme A carboxylase.
Best EA, Knauf VC.
(
7693652
)
|
|
|
Deletion
|
OCR61,62-3
(D)
,
OCR61,62-4
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
fabG
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
fabG
Search strains by all related name:
fabG accC b1093 ECK1079 JW1079
|
General information (Go to Linear View: )
|
|
Gene Name
|
fabG
|
|
Alternative name
|
accC,b1093,ECK1079,JW1079
|
|
Location, Length
|
1,149,893 - 1,150,627
(
+
)
;
24.78
min
;
735
(bp) ,
244
(aa)
|
|
Product
|
3-oxoacyl-[acyl-carrier-protein] reductase
|
|
Operon Name
|
yceD-rpmF-plsX-fabHDG-acpP-fabF
|
|
Note
|
GO_component: GO:0005737 - cytoplasm
|
|
Function
|
enzyme; Fatty acid and phosphatidic acid biosynthesis
|
|
Gene Ontology
|
GO:0000166
;
nucleotide binding ( accC )
GO:0003824
;
catalytic activity ( accC )
GO:0003824
;
catalytic activity ( fabG )
GO:0003989
;
acetyl-CoA carboxylase activity ( accC )
GO:0004075
;
biotin carboxylase activity ( accC )
GO:0004316
;
3-oxoacyl-[acyl-carrier-protein] reductase activity ( fabG )
GO:0005488
;
binding ( fabG )
GO:0005524
;
ATP binding ( accC )
GO:0006633
;
fatty acid biosynthetic process ( accC )
GO:0006633
;
fatty acid biosynthetic process ( fabG )
GO:0008152
;
metabolic process ( accC )
GO:0008152
;
metabolic process ( fabG )
GO:0008610
;
lipid biosynthetic process ( accC )
GO:0008610
;
lipid biosynthetic process ( fabG )
GO:0009374
;
biotin binding ( accC )
GO:0016491
;
oxidoreductase activity ( fabG )
GO:0016874
;
ligase activity ( accC )
GO:0051287
;
NAD binding ( fabG )
|
|
PID
|
1787335
|
EC number
(KEGG Pathway)
|
1.1.1.100
|
|
SWISS-PROT
(
Show details
[
4
more]
)
|
Entry name(Acc.no)
|
ACCC_ECOLI
(
P24182
)
|
|
- Protein name
|
Biotin carboxylase
|
|
- Synonyms
|
EC 6.3.4.14, A subunit of acetyl-CoA carboxylase, EC 6.4.1.2, ACC
|
|
- Gene name
|
Name=accC; Synonyms=fabG; OrderedLocusNames=b3256;
|
|
Homology Analysis
|
|
BLAST
|
|
Bacteria
|
|
GTOP
|
fabG
(
homologous genes of other bacterias
)
accC
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Crystal Structure Of Beta-Ketoacyl [acyl Carrier Protein] Reductase From E. Coli.
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier protein reductase)
|
|
PSI-BLAST
|
3-oxoacyl-[acyl-carrier-protein] reductase
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
3-oxoacyl-[acyl-carrier-protein] reductase [Escherichia coli K12]
|
|
Pfam 28.0
(database updated :
2015-05
)
|
|
Pfam
|
|
|
PROSITE
|
|
PROSITE
|
ASN_GLYCOSYLATION
CK2_PHOSPHO_SITE
MYRISTYL
ADH_SHORT
|
|
MMBR References
|
Proc Natl Acad Sci U S A. 1991;88:9730-9733
Acetyl-CoA carboxylase from Escherichia coli: gene organization and nucleotide sequence of the biotin carboxylase subunit.
Kondo, H., K. Shiratsuchi, T. Yoshimoto, T. Masuda, A. Kitazono, D. Tsuru, M. Anai, M. Sekiguchi, and T. Tanabe.
|
J Bacteriol. 1992;174(23):7873-4.
Physical locations of genes in the rne (ams)-rpmF-plsX-fab region of the Escherichia coli K-12 chromosome.
Oh W, Larson TJ.
(
1447160
)
|
J Biol Chem. 1992;267:5751-5754
The gene encoding Escherichia coli acyl carrier protein lies within a cluster of fatty acid biosynthetic genes.
Rawlings, M., and J. E. Cronan, Jr.
|
| Sequences |
Amino acid
FASTA format
|
0001 MNFEGKIALV TGASRGIGRA IAETLAARGA KVIGTATSEN GAQAISDYLG ANGKGLMLNV TDPASIESVL
0071 EKIRAEFGEV DILVNNAGIT RDNLLMRMKD EEWNDIIETN LSSVFRLSKA VMRAMMKKRH GRIITIGSVV
0141 GTMGNGGQAN YAAAKAGLIG FSKSLAREVA SRGITVNVVA PGFIETDMTR ALSDDQRAGI LAQVPAGRLG
0211 GAQEIANAVA FLASDEAAYI TGETLHVNGG MYMV
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 TACTGGCCTG ACGAAACGCA TTGTCGACAC
-070 CCTGACCGCC TCGGCGCTGA ACGAACCTTC AGCGATGGCA GCGGCGCTCG AGCTTTAAAA GAGGAAAATC
0001 atgaattttg aaggaaaaat cgcactggta accggtgcaa gccgcggaat tggccgcgca attgctgaaa
0071 cgctcgcagc ccgtggcgcg aaagttattg gcactgcgac cagtgaaaat ggcgctcagg cgatcagtga
0141 ttatttaggt gccaacggca aaggtctgat gttgaatgtg accgacccgg catctatcga atctgttctg
0211 gaaaaaattc gcgcagaatt tggtgaagtg gatatcctgg tcaataatgc cggtatcact cgtgataacc
0281 tgttaatgcg aatgaaagat gaagagtgga acgatattat cgaaaccaac ctttcatctg ttttccgtct
0351 gtcaaaagcg gtaatgcgcg ctatgatgaa aaagcgtcat ggtcgtatta tcactatcgg ttctgtggtt
0421 ggtaccatgg gaaatggcgg tcaggccaac tacgctgcgg cgaaagcggg cttgatcggc ttcagtaaat
0491 cactggcgcg cgaagttgcg tcacgcggta ttactgtaaa cgttgttgct ccgggcttta ttgaaacgga
0561 catgacacgt gcgctgagcg atgaccagcg tgcgggtatc ctggcgcagg ttcctgcggg tcgcctcggc
0631 ggcgcacagg aaatcgccaa cgcggttgca ttcctggcat ccgacgaagc agcttacatc acgggtgaaa
0701 ctttgcatgt gaacggcggg atgtacatgg tctgaCCGCG ATTTGCACAA AATGCTCATG TTGCGCGCAG
0771 TCTGCGTGGT TATGAGTAAT AATTAGTGCA AAATGATTTG CGTTATTGGG GGGTAAGGCC TCAAA
|
