|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
essential
|
|
References (PMID)
|
FEBS Lett. 1994;348(3):311-6.
Molecular characterization of an Escherichia coli mutant with a temperature-sensitive malonyl coenzyme A-acyl carrier protein transacylase.
Verwoert II, Verhagen EF, van der Linden KH, Verbree EC, Nijkamp HJ, Stuitje AR.
(
8034061
)
|
|
|
Deletion
|
OCR61,62-3
(D)
,
OCR61,62-4
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
fabD
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
fabD
Search strains by all related name:
fabD b1092 ECK1078 JW1078 tfpA
|
General information (Go to Linear View: )
|
|
Gene Name
|
fabD
|
|
Alternative name
|
b1092,ECK1078,JW1078,tfpA
|
|
Location, Length
|
1,148,951 - 1,149,880
(
+
)
;
24.76
min
;
930
(bp) ,
309
(aa)
|
|
Product
|
malonyl-CoA-[acyl-carrier-protein] transacylase
|
|
Operon Name
|
yceD-rpmF-plsX-fabHDG-acpP-fabF
|
|
Note
|
GO_component: GO:0005737 - cytoplasm
|
|
Function
|
enzyme; Fatty acid and phosphatidic acid biosynthesis
|
|
Gene Ontology
|
GO:0003824
;
catalytic activity ( fabD )
GO:0004314
;
[acyl-carrier-protein] S-malonyltransferase activity ( fabD )
GO:0005488
;
binding ( fabD )
GO:0005737
;
cytoplasm ( fabD )
GO:0006633
;
fatty acid biosynthetic process ( fabD )
GO:0008152
;
metabolic process ( fabD )
GO:0008610
;
lipid biosynthetic process ( fabD )
GO:0016740
;
transferase activity ( fabD )
|
|
PID
|
1787334
|
EC number
(KEGG Pathway)
|
2.3.1.39
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
fabD
(
EG11317
)
|
|
Number of removed
|
1 aa cleaved
|
|
SWISS-PROT
(
Show details
[
1
more]
)
|
Entry name(Acc.no)
|
FABD_ECOLI
(
P25715
)
|
|
- Protein name
|
Malonyl CoA-acyl carrier protein transacylase
|
|
- Synonyms
|
EC 2.3.1.39, MCT
|
|
- Gene name
|
Name=fabD; Synonyms=tfpA; OrderedLocusNames=b1092, c1361;
|
|
MMBR References
|
J Biol Chem. 1980;255:11949-11956
Structural, enzymatic, and genetic studies of beta-ketoacylacyl carrier protein synthases I and II of Escherichia coli.
Garwin, J. L., A. L. Klages, and J. E. Cronan, Jr.
|
FEBS Lett. 1992;299(3):262-6.
Cloning and nucleotide sequence of the fabD gene encoding malonyl coenzyme A-acyl carrier protein transacylase of Escherichia coli.
Magnuson K, Oh W, Larson TJ, Cronan JE Jr.
(
1339356
)
|
J Bacteriol. 1992;174:2851-2857
Cloning, nucleotide sequence, and expression of the Escherichia coli fabD gene, encoding malonyl coenzyme A-acyl carrier protein transacylase.
Verwoert, I., E. C. Verbree, K. H. van der Linden, H. J. Nijkamp, and A. R. Stuitje.
|
| Sequences |
Amino acid
FASTA format
|
0001 MTQFAFVFPG QGSQTVGMLA DMAASYPIVE ETFAEASAAL GYDLWALTQQ GPAEELNKTW QTQPALLTAS
0071 VALYRVWQQQ GGKAPAMMAG HSLGEYSALV CAGVIDFADA VRLVEMRGKF MQEAVPEGTG AMAAIIGLDD
0141 ASIAKACEEA AEGQVVSPVN FNSPGQVVIA GHKEAVERAG AACKAAGAKR ALPLPVSVPS HCALMKPAAD
0211 KLAVELAKIT FNAPTVPVVN NVDVKCETNG DAIRDALVRQ LYNPVQWTKS VEYMAAQGVE HLYEVGPGKV
0281 LTGLTKRIVD TLTASALNEP SAMAAALEL
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 CGGGCGCATT AAGCCGGGGC AGTTGGTTCT
-070 GCTTGAAGCC TTTGGCGGTG GATTCACCTG GGGCTCCGCG CTGGTTCGTT TCTAGGATAA GGATTAAAAC
0001 atgacgcaat ttgcatttgt gttccctgga cagggttctc aaaccgttgg aatgctggct gatatggcgg
0071 cgagctatcc aattgtcgaa gaaacgtttg ctgaagcttc tgcggcgctg ggctacgacc tgtgggcgct
0141 gacccagcag gggccagctg aagaactgaa taaaacctgg caaactcagc ctgcgctgtt gactgcatct
0211 gttgcgctgt atcgcgtatg gcagcagcag ggcggtaaag caccggcaat gatggccggt cacagcctgg
0281 gggaatactc cgcgctggtt tgcgctggtg tgattgattt cgctgatgcg gtgcgtctgg ttgagatgcg
0351 cggcaagttc atgcaagaag ccgtaccgga aggcacgggc gctatggcgg caatcatcgg tctggatgat
0421 gcgtctattg cgaaagcgtg tgaagaagct gcagaaggtc aggtcgtttc tccggtaaac tttaactctc
0491 cgggacaggt ggttattgcc ggtcataaag aagcggttga gcgtgctggc gctgcctgta aagcggcggg
0561 cgcaaaacgc gcgctgccgt taccagtgag cgtaccgtct cactgtgcgc tgatgaaacc agcagccgac
0631 aaactggcag tagaattagc gaaaatcacc tttaacgcac caacagttcc tgttgtgaat aacgttgatg
0701 tgaaatgcga aaccaatggt gatgccatcc gtgacgcact ggtacgtcag ttgtataacc cggttcagtg
0771 gacgaagtct gttgagtaca tggcagcgca aggcgtagaa catctctatg aagtcggccc gggcaaagtg
0841 cttactggcc tgacgaaacg cattgtcgac accctgaccg cctcggcgct gaacgaacct tcagcgatgg
0911 cagcggcgct cgagctttaa AAGAGGAAAA TCATGAATTT TGAAGGAAAA ATCGCACTGG TAACCGGTGC
0981 AAGCCGCGGA ATTGGCCGCG CAATTGCTGA AACGCTCGCA GCCCGTGGCG
|
