|
PEC Original Annotations
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|
Essentiality
|
|
Class
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non-essential
|
|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
|
Deletion
|
OCR60
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
pyrC
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
pyrC
Search strains by all related name:
pyrC b1062 ECK1047 JW1049
|
General information (Go to Linear View: )
|
|
Gene Name
|
pyrC
|
|
Alternative name
|
b1062,ECK1047,JW1049
|
|
Location, Length
|
1,120,784 - 1,121,830
(
-
)
;
24.16
min
;
1047
(bp) ,
348
(aa)
|
|
Product
|
dihydro-orotase
|
|
Operon Name
|
pyrC
|
|
Note
|
GO_component: GO:0005737 - cytoplasm; GO_process: GO:0006221 - pyrimidine nucleotide biosynthetic process
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Function
|
enzyme; Pyrimidine ribonucleotide biosynthesis
|
|
Gene Ontology
|
GO:0004151
;
dihydroorotase activity ( pyrC )
GO:0006221
;
pyrimidine nucleotide biosynthetic process ( pyrC )
GO:0008270
;
zinc ion binding ( pyrC )
GO:0016787
;
hydrolase activity ( pyrC )
GO:0016812
;
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides ( pyrC )
GO:0019856
;
pyrimidine base biosynthetic process ( pyrC )
GO:0046872
;
metal ion binding ( pyrC )
|
|
PID
|
1787301
|
EC number
(KEGG Pathway)
|
3.5.2.3
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
pyrC
(
EG10806
)
|
|
Number of removed
|
1 aa cleaved
|
|
SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
PYRC_ECOLI
(
P05020
)
|
|
- Protein name
|
Dihydroorotase
|
|
- Synonyms
|
EC 3.5.2.3, DHOase
|
|
- Gene name
|
Name=pyrC; OrderedLocusNames=b1062;
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Homology Analysis
|
|
BLAST
|
|
Bacteria
|
|
GTOP
|
pyrC
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Dihydroorotase From Escherichia Coli: Loop Movement And Cooperativity Between Subunits
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Dihydroorotase
|
|
PSI-BLAST
|
Urease alpha subunit
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
dihydroorotase [Escherichia coli K12]
|
|
Pfam 28.0
(database updated :
2015-05
)
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Pfam
|
|
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PROSITE
|
|
PROSITE
|
ASN_GLYCOSYLATION
CAMP_PHOSPHO_SITE
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
DIHYDROOROTASE_1
DIHYDROOROTASE_2
|
|
MMBR References
|
Eur J Biochem. 1986;160:77-82
Nucleotide sequence of the structural gene for dihydroorotase of Escherichia coli K-12.
Backstrom, D., R.-M. Sjoberg, and L. G. Lundberg.
|
Eur J Biochem. 1984;140:343-352
Studies on the structure and expression of Escherichia coli pyrC, pyrD and pyrF using the cloned genes.
Jensen, K. F., J. N. Larsen, L. Schack, and A. Sivertsen.
|
J Bacteriol. 1987;169(7):3051-8.
Nucleotide sequence and expression of the pyrC gene of Escherichia coli K-12.
Wilson HR, Chan PT, Turnbough CL Jr.
(
2885307
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MTAPSQVLKI RRPDDWHLHL RDGDMLKTVV PYTSEIYGRA IVMPNLAPPV TTVEAAVAYR QRILDAVPAG
0071 HDFTPLMTCY LTDSLDPNEL ERGFNEGVFT AAKLYPANAT TNSSHGVTSI DAIMPVLERM EKIGMPLLVH
0141 GEVTHADIDI FDREARFIES VMEPLRQRLT ALKVVFEHIT TKDAADYVRD GNERLAATIT PQHLMFNRNH
0211 MLVGGVRPHL YCLPILKRNI HQQALRELVA SGFNRVFLGT DSAPHARHRK ESSCGCAGCF NAPTALGSYA
0281 TVFEEMNALQ HFEAFCSVNG PQFYGLPVND TFIELVREEQ QVAESIALTD DTLVPFLAGE TVRWSVKQ
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 agggcgcatt cgcgcccttt atttttcgtg
-070 caaaggaaaa cgtttccgct tatcctttgt gtccggcaaa aacatccctt cagccggagc atagagatta
0001 atgactgcac catcccaggt attaaagatc cgccgcccag acgactggca ccttcacctc cgcgatggcg
0071 acatgttaaa aactgtcgtg ccatatacca gcgaaattta tggacgggct atcgtaatgc ccaatctggc
0141 tccgcccgtg accaccgttg aggctgccgt ggcgtatcgc cagcgtattc ttgacgccgt acctgccggg
0211 cacgatttca ccccattgat gacctgttat ttaacagatt cgctggatcc taatgagctg gagcgcggat
0281 ttaacgaagg cgtgttcacc gctgcaaaac tttacccggc aaacgcaacc actaactcca gccacggcgt
0351 gacgtcaatt gacgcaatca tgccggtact tgagcgcatg gaaaaaatcg gtatgccgct actggtgcat
0421 ggtgaagtga cacatgcaga tatcgacatt tttgatcgtg aagcgcgctt tatagaaagc gtgatggaac
0491 ctctgcgcca gcgcctgact gcgctgaaag tcgtttttga gcacatcacc accaaagatg ctgccgacta
0561 tgtccgtgac ggaaatgaac ggctggctgc caccatcact ccgcagcatc tgatgtttaa ccgcaaccat
0631 atgctggttg gaggcgtgcg tccgcacctg tattgtctac ccatcctcaa acgtaatatt caccaacagg
0701 cattgcgtga actggtcgcc agcggtttta atcgagtatt cctcggtacg gattctgcgc cacatgcacg
0771 tcatcgcaaa gagagcagtt gcggctgcgc gggctgcttc aacgccccaa ccgcgctggg cagttacgct
0841 accgtctttg aagaaatgaa tgctttgcag cactttgaag cattctgttc tgtaaacggc ccgcagttct
0911 atgggttgcc ggtcaacgac acattcatcg aactggtacg tgaagagcaa caggttgctg aaagcatcgc
0981 actgactgat gacacgctgg tgccattcct cgccggggaa acggtacgct ggtccgttaa acaataaaaa
1051 tcgtagcttc ctgttgtcat taggttattt tacctgtata aataaccagt atattcaaca gggggctatt
1121 atgcgaattg aagtcaccat agcgaaa
|
