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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
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Deletion
|
OCR26
(D)
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|
Related gene (W3110 PEC)
|
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Gene Search
|
Search MG1655 PEC by gene name:
deoC
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Related strains
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Strains Search
|
Search strains by gene name:
deoC
Search strains by all related name:
deoC b4381 dra ECK4373 JW4344 thyR tlr trl
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General information (Go to Linear View: )
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Gene Name
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deoC
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Alternative name
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b4381,dra,ECK4373,JW4344,thyR,tlr,trl
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Location, Length
|
4,615,346 - 4,616,125
(
+
)
;
99.48
min
;
780
(bp) ,
259
(aa)
|
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Product
|
2-deoxyribose-5-phosphate aldolase, NAD(P)-linked
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Operon Name
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deoCABD
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Note
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2-deoxyribose-5-phosphate aldolase; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0015949 - nucleobase, nucleoside and nucleotide interconversion
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Function
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enzyme; Salvage of nucleosides and nucleotides
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Gene Ontology
|
GO:0003824
;
catalytic activity ( deoC )
GO:0004139
;
deoxyribose-phosphate aldolase activity ( deoC )
GO:0005624
;
membrane fraction ( deoC )
GO:0005737
;
cytoplasm ( deoC )
GO:0008152
;
metabolic process ( deoC )
GO:0009264
;
deoxyribonucleotide catabolic process ( deoC )
GO:0016052
;
carbohydrate catabolic process ( deoC )
GO:0016829
;
lyase activity ( deoC )
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PID
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1790841
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EC number
(KEGG Pathway)
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4.1.2.4
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Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
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EcoGene
|
deoC
(
EG10221
)
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Number of removed
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1 aa cleaved
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SWISS-PROT
(
Show details
[
1
more]
)
|
Entry name(Acc.no)
|
DEOC_ECOLI
(
P00882
)
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- Protein name
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Deoxyribose-phosphate aldolase
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- Synonyms
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EC 4.1.2.4, Phosphodeoxyriboaldolase, Deoxyriboaldolase, DERA
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- Gene name
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Name=deoC; Synonyms=dra, thyR; OrderedLocusNames=b4381, c5465;
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MMBR References
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Gene. 1982;17(3):291-8.
The cloning of the Escherichia coli K-12 deoxyribonucleoside operon.
Fischer M, Short SA.
(
6286410
)
|
J Bacteriol. 1968;96(2):501-14.
Characteristics of the deo operon: role in thymine utilization and sensitivity to deoxyribonucleosides.
Lomax MS, Greenberg GR.
(
4877128
)
|
Mol Gen Genet. 1979;176(3):361-8.
Cloning the trpR gene.
Roeder W, Somerville RL.
(
160491
)
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EMBO J. 1982;1(9):1049-54.
Tandem CRP binding sites in the deo operon of Escherichia coli K-12.
Valentin-Hansen P.
(
6329724
)
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Eur J Biochem. 1982;125:561-566
The primary structure of Escherichia coli K12 2-deoxyribose 5-phosphate aldolase. Nucleotide sequence of the deoC gene and the amino acid sequence of the enzyme.
Valentin-Hansen, P., F. Boetius, K. Hammer-Jespersen, and I. Svendsen.
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EMBO J. 1982;1:317-322.
The structure of tandem regulatory regions in the deo operon of Escherichia coli K12.
Valentin-Hansen, P., H. Aiba, and D. Schumperli.
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J Mol Biol. 1979;133(1):1-17.
Evidence for the existence of three promoters for the deo operon of Escherichia coli K12 in vitro.
Valentin-Hansen P, Hammer-Jespersen K, Buxton RS.
(
231107
)
|
Mol Gen Genet. 1980;179(2):457-60.
Regulation of the synthesis of nucleoside catabolic enzymes in Escherichia coli: further analysis of a deo Oc mutant strain.
Albrechtsen H, Ahmad SI.
(
6780756
)
|
EMBO J. 1985;4:3333-3338
Two operator sites separated by 599 base pairs are required for deoR repression of the deo operon of Escherichia coli.
Dandanell, G., and K. Hammer.
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| Sequences |
Amino acid
FASTA format
|
0001 MTDLKASSLR ALKLMDLTTL NDDDTDEKVI ALCHQAKTPV GNTAAICIYP RFIPIARKTL KEQGTPEIRI
0071 ATVTNFPHGN DDIDIALAET RAAIAYGADE VDVVFPYRAL MAGNEQVGFD LVKACKEACA AANVLLKVII
0141 ETGELKDEAL IRKASEISIK AGADFIKTST GKVAVNATPE SARIMMEVIR DMGVEKTVGF KPAGGVRTAE
0211 DAQKYLAIAD ELFGADWADA RHYRFGASSL LASLLKALGH GDGKSASSY
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 CCTTAATTGT GATGTGTATC GAAGTGTGTT
-070 GCGGAGTAGA TGTTAGAATA CTAACAAACT CGCAAGGTGA ATTTTATTGG CGACAAGCCA GGAGAATGAA
0001 atgactgatc tgaaagcaag cagcctgcgt gcactgaaat tgatggacct gaccaccctg aatgacgacg
0071 acaccgacga gaaagtgatc gccctgtgtc atcaggccaa aactccggtc ggcaataccg ccgctatctg
0141 tatctatcct cgctttatcc cgattgctcg caaaactctg aaagagcagg gcaccccgga aatccgtatc
0211 gctacggtaa ccaacttccc acacggtaac gacgacatcg acatcgcgct ggcagaaacc cgtgcggcaa
0281 tcgcctacgg tgctgatgaa gttgacgttg tgttcccgta ccgcgcgctg atggcgggta acgagcaggt
0351 tggttttgac ctggtgaaag cctgtaaaga ggcttgcgcg gcagcgaatg tactgctgaa agtgatcatc
0421 gaaaccggcg aactgaaaga cgaagcgctg atccgtaaag cgtctgaaat ctccatcaaa gcgggtgcgg
0491 acttcatcaa aacctctacc ggtaaagtgg ctgtgaacgc gacgccggaa agcgcgcgca tcatgatgga
0561 agtgatccgt gatatgggcg tagaaaaaac cgttggtttc aaaccggcgg gcggcgtgcg tactgcggaa
0631 gatgcgcaga aatatctcgc cattgcagat gaactgttcg gtgctgactg ggcagatgcg cgtcactacc
0701 gctttggcgc ttccagcctg ctggcaagcc tgctgaaagc gctgggtcac ggcgacggta agagcgccag
0771 cagctactaa GTAAGATGCT TTACGCCTGA TGCGCTGCGC TTATCAGGCC TACGAGACGT ATCTACCCGT
0841 AGGCCGGATA AGGCGTAGAC GCATCCGGCA AAAGCCGCCT
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