MG1655
W3110
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Gene Report : mltD
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
FEMS Microbiol Lett. 1991;67(2):205-11.
Molecular cloning and DNA sequence of dniR, a gene affecting anaerobic expression of the Escherichia coli hexaheme nitrite reductase.
Kajie S, Ideta R, Yamato I, Anraku Y. ( 1663890 )
     Deletion OCR36 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  mltD
Related strains
     Strains Search Search strains by gene name:  mltD   Search strains by all related name:  mltD b0211 dniR ECK0211 f452 JW5018 yafG

General information  (Go to Linear View:)
 Gene Name mltD  
 Alternative name b0211,dniR,ECK0211,f452,JW5018,yafG  
 Location, Length 232,597 - 233,955 (  -  ) ;   5.01 min ; 1359 (bp) ,   452 (aa) Go to Linear View
 Product putative membrane-bound lytic murein transglycosylase D  
 Operon Name mltD  
 Note GO_component: GO:0005737 - cytoplasm; GO_function: GO:0016563 - transcription activator activity; GO_process: GO:0009061 - anaerobic respiration; GO_process: GO:0017004 - cytochrome complex assembly; GO_process: GO:0006350 - transcription  
 Function regulator; Energy metabolism, carbon: Anaerobic respiration  
 Gene Ontology GO:0005576 ; extracellular region ( mltD )
GO:0005886 ; plasma membrane ( mltD )
GO:0007047 ; cell wall organization and biogenesis ( mltD )
GO:0008152 ; metabolic process ( mltD )
GO:0016020 ; membrane ( mltD )
GO:0016787 ; hydrolase activity ( mltD )
GO:0016798 ; hydrolase activity, acting on glycosyl bonds ( mltD )
GO:0016998 ; cell wall catabolic process ( mltD )
GO:0019867 ; outer membrane ( mltD )
 PID 1786405  
 EC number
  (KEGG Pathway)   		3.2.1.-  
SWISS-PROT  ( Show details [ 1 more] )
  botton Entry name(Acc.no) MLTD_ECOLI ( P23931 ; P32982; P77350 )
    -  Protein name Membrane-bound lytic murein transglycosylase D precursor  
    -  Synonyms EC 3.2.1.-, Murein hydrolase D, Regulatory protein dniR  
    -  Gene name Name=mltD; Synonyms=dniR; OrderedLocusNames=b0211, c0248;  

 Linear View (Whole Mode)
View Location
   220.0  –  245.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP mltD (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Crystal Structure Of The 70 Kda Soluble Lytic Transglycosylase Slt70 From Escherichia Coli At 1.65 Angstroms Resolution  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Membrane-bound lytic murein transglycosylase D precursor (Murein hydrolase D) (Regulatory protein dniR)  
         PSI-BLAST Membrane-bound lytic murein transglycosylase D precursor (Murein hydrolase D) (Regulatory protein dniR)
    nr     (database updated : 2007.02.20 )
         BLAST predicted membrane-bound lytic murein transglycosylase D [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    GLYCOSAMINOGLYCAN    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    PROKAR_LIPOPROTEIN    TRANSGLYCOSYLASE     

Other Cross-Reference
    COG COG0741M 
    EcoCyc mltD 

MMBR References
FEMS Microbiol Lett. 1991;67(2):205-11.
Molecular cloning and DNA sequence of dniR, a gene affecting anaerobic expression of the Escherichia coli hexaheme nitrite reductase.
Kajie S, Ideta R, Yamato I, Anraku Y. ( 1663890 )

Sequences
Amino acid
FASTA format 
0001 MKAKAILLAS VLLVGCQSTG NVQQHAQSLS AAGQGEAAKF TSQARWMDDG TSIAPDGDLW AFIGDELKMG 
0071 IPENDRIREQ KQKYLRNKSY LHDVTLRAEP YMYWIAGQVK KRNMPMELVL LPIVESAFDP HATSGANAAG 
0141 IWQIIPSTGR NYGLKQTRNY DARRDVVAST TAALNMMQRL NKMFDGDWLL TVAAYNSGEG RVMKAIKTNK 
0211 ARGKSTDFWS LPLPQETKQY VPKMLALSDI LKNSKRYGVR LPTTDESRAL ARVHLSSPVE MAKVADMAGI 
0281 SVSKLKTFNA GVKGSTLGAS GPQYVMVPKK HADQLRESLA SGEIAAVQST LVADNTPLNS RVYTVRSGDT 
0351 LSSIASRLGV STKDLQQWNK LRGSKLKPGQ SLTIGAGSSA QRLANNSDSI TYRVRKGDSL SSIAKRHGVN 
0421 IKDVMRWNSD TANLQPGDKL TLFVKNNNMP DS
Nucleotide
FASTA format

View sequence out neighbor 100bp 
-100                                             ggttaaggtc aaagaaagat aggttctgat 
-070 aaaactttct tgtcatcggc tccgttcgcc gttatgatcg gtcgtctttt aagcaactat tgacacacac 
0001 atgaaggcaa aagcgatatt actcgcctct gtcctgctcg tgggttgcca gagtaccggc aacgttcaac 
0071 agcacgcaca gagcctttct gcagctggtc aaggggaagc agcaaagttt acaagtcagg cacgatggat 
0141 ggacgatggg acgtctatcg cgccagatgg tgacttgtgg gctttcattg gcgacgagct aaagatggga 
0211 attccggaaa atgaccggat tcgcgaacag aaacagaaat atttacgcaa taagagctat ctccacgatg 
0281 taactttacg ggcagagccg tatatgtact ggatagcagg gcaagttaaa aaacgtaaca tgcctatgga 
0351 actggtacta ctacccatag tggagagcgc ttttgatcct cacgcaacgt ctggcgccaa tgccgcaggc 
0421 atctggcaga tcattccgag cacggggcgc aattatggtt tgaaacagac ccgcaattat gacgcgcgtc 
0491 gcgatgttgt tgcttcaaca actgccgcgc tgaatatgat gcagcgtctg aacaaaatgt ttgacggcga 
0561 ctggcttctg accgtagcgg cttataacag cggcgaaggt cgggtcatga aggcaattaa aacgaacaaa 
0631 gcgcgtggga aatccacgga cttctggtcg ttaccgttgc cgcaggaaac gaagcagtac gtgcctaaaa 
0701 tgctggcatt gagtgatatt ctcaaaaaca gcaagcgtta tggcgtacgt ctgccaacga ccgatgaaag 
0771 ccgtgctctg gcgcgtgtgc acctgagcag cccggttgaa atggcgaagg tagcagatat ggcggggatt 
0841 tccgtcagca agctgaagac attcaacgct ggcgtaaaag gctccacgct gggcgcaagt ggcccgcagt 
0911 acgtgatggt gccaaagaag catgcagatc aactgcgtga atctctggct tcaggcgaaa ttgctgctgt 
0981 acagtcgacg ctggttgccg acaatacgcc gcttaacagc cgtgtttaca ccgtacgctc tggcgacacg 
1051 ctttcaagta tcgcttcacg tctcggcgta agcaccaaag atttgcagca gtggaacaaa ctgcgcggat 
1121 ctaagctgaa gccaggccaa agtttgacga ttggtgcagg cagtagcgca cagcgactgg caaacaacag 
1191 cgatagcatt acgtatcgtg tgcgcaaagg cgattcgctt tcaagcattg ctaaacgcca cggcgtgaac 
1261 atcaaagatg tgatgcgctg gaacagcgac actgcgaatc tgcaaccagg cgataagctg acgttgtttg 
1331 tgaaaaacaa caacatgcca gattcctgac aaaccagata ataaaaaggc accgattccc ccggtgcctt 
1401 ttttatttat gccgctttat gtgcatctac catgatgata tcactggtga aaaagccat