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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
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Deletion
|
OCL52,53-1
(D)
,
OCL52-3
(D)
|
|
Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
pheA
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Related strains
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Strains Search
|
Search strains by gene name:
pheA
Search strains by all related name:
pheA b2599 ECK2596 JW2580
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General information (Go to Linear View: )
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Gene Name
|
pheA
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Alternative name
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b2599,ECK2596,JW2580
|
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Location, Length
|
2,735,767 - 2,736,927
(
+
)
;
58.96
min
;
1161
(bp) ,
386
(aa)
|
|
Product
|
fused chorismate mutase P/prephenate dehydratase
|
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Operon Name
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pheLA
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Note
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chorismate mutase-P and prephenate dehydratase; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0009094 - L-phenylalanine biosynthetic process; GO_process: GO:0006571 - tyrosine biosynthetic process
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Function
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enzyme; Amino acid biosynthesis: Phenylalanine
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Gene Ontology
|
GO:0003824
;
catalytic activity ( pheA )
GO:0004106
;
chorismate mutase activity ( pheA )
GO:0004664
;
prephenate dehydratase activity ( pheA )
GO:0005515
;
protein binding ( pheA )
GO:0005737
;
cytoplasm ( pheA )
GO:0008652
;
amino acid biosynthetic process ( pheA )
GO:0009073
;
aromatic amino acid family biosynthetic process ( pheA )
GO:0009094
;
L-phenylalanine biosynthetic process ( pheA )
GO:0016829
;
lyase activity ( pheA )
GO:0016853
;
isomerase activity ( pheA )
|
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PID
|
1788951
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EC number
(KEGG Pathway)
|
4.2.1.51
5.4.99.5
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SWISS-PROT
(
Show details
[
1
more]
)
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Entry name(Acc.no)
|
PHEA_ECOLI
(
P07022
;
P78204
)
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- Protein name
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P-protein
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- Synonyms
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- Gene name
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Name=pheA; OrderedLocusNames=b2599, z3891, ECs3462, SF2659, S2836;
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MMBR References
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J Biol Chem. 1990;265:21532-21535
pheAo mutants of Escherichia coli have a defective pheA attenuator.
Gavini, N., and B. E. Davidson.
|
J Biol Chem. 1991;266:7750-7753
Regulation of pheA expression by the pheR product in Escherichia coli is mediated through attenuation of transcription.
Gavini, N., and B. E. Davidson.
|
J Gen Microbiol. 1991;137(3):679-84.
Role of ribosome release in the basal level of expression of the Escherichia coli gene pheA.
Gavini N, Pulakat L.
(
1709680
)
|
J Bacteriol. 1982;150(3):1122-9.
Construction from Mu d1 (lac Apr) lysogens of lambda bacteriophage bearing promoter-lac fusions: isolation of lambda ppheA-lac.
Gowrishankar J, Pittard J.
(
6281237
)
|
J Bacteriol. 1982;150(3):1130-7.
Regulation of phenylalanine biosynthesis in Escherichia coli K-12: control of transcription of the pheA operon.
Gowrishankar J, Pittard J.
(
7042684
)
|
J Mol Biol. 1984;180(4):1023-51.
Nucleotide sequence and transcription of the phenylalanine and tyrosine operons of Escherichia coli K12.
Hudson GS, Davidson BE.
(
6396419
)
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| Sequences |
Amino acid
FASTA format
|
0001 MTSENPLLAL REKISALDEK LLALLAERRE LAVEVGKAKL LSHRPVRDID RERDLLERLI TLGKAHHLDA
0071 HYITRLFQLI IEDSVLTQQA LLQQHLNKIN PHSARIAFLG PKGSYSHLAA RQYAARHFEQ FIESGCAKFA
0141 DIFNQVETGQ ADYAVVPIEN TSSGAINDVY DLLQHTSLSI VGEMTLTIDH CLLVSGTTDL STINTVYSHP
0211 QPFQQCSKFL NRYPHWKIEY TESTSAAMEK VAQAKSPHVA ALGSEAGGTL YGLQVLERIE ANQRQNFTRF
0281 VVLARKAINV SDQVPAKTTL LMATGQQAGA LVEALLVLRN HNLIMTRLES RPIHGNPWEE MFYLDIQANL
0351 ESAEMQKALK ELGEITRSMK VLGCYPSENV VPVDPT
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 GAATGGGAGG CGTTTCGTCG TGTGAAACAG
-070 AATGCGAAGA CGAACAATAA GGCCTCCCAA ATCGGGGGGC CTTTTTTATT GATAACAAAA AGGCAACACT
0001 atgacatcgg aaaacccgtt actggcgctg cgagagaaaa tcagcgcgct ggatgaaaaa ttattagcgt
0071 tactggcaga acggcgcgaa ctggccgtcg aggtgggaaa agccaaactg ctctcgcatc gcccggtacg
0141 tgatattgat cgtgaacgcg atttgctgga aagattaatt acgctcggta aagcgcacca tctggacgcc
0211 cattacatta ctcgcctgtt ccagctcatc attgaagatt ccgtattaac tcagcaggct ttgctccaac
0281 aacatctcaa taaaattaat ccgcactcag cacgcatcgc ttttctcggc cccaaaggtt cttattccca
0351 tcttgcggcg cgccagtatg ctgcccgtca ctttgagcaa ttcattgaaa gtggctgcgc caaatttgcc
0421 gatattttta atcaggtgga aaccggccag gccgactatg ccgtcgtacc gattgaaaat accagctccg
0491 gtgccataaa cgacgtttac gatctgctgc aacataccag cttgtcgatt gttggcgaga tgacgttaac
0561 tatcgaccat tgtttgttgg tctccggcac tactgattta tccaccatca atacggtcta cagccatccg
0631 cagccattcc agcaatgcag caaattcctt aatcgttatc cgcactggaa gattgaatat accgaaagta
0701 cgtctgcggc aatggaaaag gttgcacagg caaaatcacc gcatgttgct gcgttgggaa gcgaagctgg
0771 cggcactttg tacggtttgc aggtactgga gcgtattgaa gcaaatcagc gacaaaactt cacccgattt
0841 gtggtgttgg cgcgtaaagc cattaacgtg tctgatcagg ttccggcgaa aaccacgttg ttaatggcga
0911 ccgggcaaca agccggtgcg ctggttgaag cgttgctggt actgcgcaac cacaatctga ttatgacccg
0981 tctggaatca cgcccgattc acggtaatcc atgggaagag atgttctatc tggatattca ggccaatctt
1051 gaatcagcgg aaatgcaaaa agcattgaaa gagttagggg aaatcacccg ttcaatgaag gtattgggct
1121 gttacccaag tgagaacgta gtgcctgttg atccaacctg aTGAAAAGGT GCCGGATGAT GTGAATCATC
1191 CGGCACTGGA TTATTACTGG CGATTGTCAT TCGCCTGACG CAATAACACG CGGCTTTCAC TCTGAAAACG
1261 C
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