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PEC Original Annotations
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Essentiality
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Class
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essential
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References (PMID)
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Biochemistry. 1990;29(25):5881-9.
Initiation of mRNA translation in prokaryotes.
Gualerzi CO, Pon CL.
(
2200518
)
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Deletion
|
OCL85,86-8 (AK4-4 / BK6-4)
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
infC
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Related strains
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Strains Search
|
Search strains by gene name:
infC
Search strains by all related name:
infC b1718 ECK1716 fit JW5829 srjA
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General information (Go to Linear View: )
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Gene Name
|
infC
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Alternative name
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b1718,ECK1716,fit,JW5829,srjA
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Location, Length
|
1,798,120 - 1,798,662
(
-
)
;
38.76
min
;
543
(bp) ,
180
(aa)
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Product
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protein chain initiation factor IF-3
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Operon Name
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thrS-infC-rpmI-rplT-pheMST-ihfA
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Note
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GO_component: GO:0005737 - cytoplasm; GO_process: GO:0006412 - translation
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Function
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factor; Proteins - translation and modification
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Gene Ontology
|
GO:0003723
;
RNA binding ( infC )
GO:0003743
;
translation initiation factor activity ( infC )
GO:0005737
;
cytoplasm ( infC )
GO:0006412
;
translation ( infC )
GO:0006413
;
translational initiation ( infC )
GO:0006417
;
regulation of translation ( infC )
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PID
|
1788012
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EC number
(KEGG Pathway)
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Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
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EcoGene
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infC
(
EG10506
)
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Number of removed
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0 aa cleaved
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SWISS-PROT
(
Show details
)
|
Entry name(Acc.no)
|
IF3_ECOLI
(
P02999
;
P76905
)
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- Protein name
|
Translation initiation factor IF-3.
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- Synonyms
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- Gene name
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OrderedLocusNames=b1718, c2115, z2747, ECs2425;
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Homology Analysis
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BLAST
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Bacteria
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GTOP
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infC
(
homologous genes of other bacterias
)
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PDB
(database updated :
2007.02.20
)
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PSI-BLAST
|
Chain , Translation Initiation Factor 3 C-Terminal Domain
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SWISS-PROT
(database updated :
2007.02.20
)
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BLAST
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Translation initiation factor IF-3 [Contains: IF-3L; IF-3S]
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PSI-BLAST
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Translation initiation factor IF-3
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nr
(database updated :
2007.02.20
)
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BLAST
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translation initiation factor IF-3 [Escherichia coli O157:H7 str. Sakai]
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Pfam 28.0
(database updated :
2015-05
)
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Pfam
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PROSITE
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PROSITE
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PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
TYR_PHOSPHO_SITE
MYRISTYL
AMIDATION
IF3
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MMBR References
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J Bacteriol. 1982;152(1):357-62.
Molecular cloning and regulation of expression of the genes for initiation factor 3 and two aminoacyl-tRNA synthetases.
Elseviers D, Gallagher P, Hoffman A, Weinberg B, Schwartz I.
(
6749810
)
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J Bacteriol. 1993;175:6118-6125
Suppression of recJ mutations of Escherichia coli by mutations in translation initiation factor IF3.
Haggerty, T. J., and S. T. Lovett.
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J Mol Biol. 1992;228(2):366-86.
Messenger RNA secondary structure and translational coupling in the Escherichia coli operon encoding translation initiation factor IF3 and the ribosomal proteins, L35 and L20.
Lesage P, Chiaruttini C, Graffe M, Dondon J, Milet M, Springer M.
(
1453449
)
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J Bacteriol. 1991;173(12):3888-93.
Growth rate regulation of translation initiation factor IF3 biosynthesis in Escherichia coli.
Liveris D, Klotsky RA, Schwartz I.
(
2050639
)
|
Proc Natl Acad Sci U S A. 1983;80:6152-6156
Structural and transcriptional evidence for related thrS and infC expression.
Mayaux, J.-F., G. Fayat, M. Fromant, M. Springer, and M. Grunberg-Manago.
|
Gene. 1989;80(2):369-74.
Inducible high expression of the Escherichia coli infC gene subcloned behind a bacteriophage T7 promoter.
Muralikrishna P, Wickstrom E.
(
2684768
)
|
Gene. 1980;11(1-2):33-42.
Physical localisation and cloning of the structural gene for E. coli initiation factor IF3 from a group of genes concerned with translation.
Plumbridge JA, Springer M, Graffe M, Goursot R, Grunberg-Manago M.
(
6254853
)
|
J Bacteriol. 1986;168(2):746-51.
Expression of Escherichia coli infC: identification of a promoter in an upstream thrS coding sequence.
Pramanik A, Wertheimer SJ, Schwartz JJ, Schwartz I.
(
3536858
)
|
EMBO J. 1982;1(3):311-5.
Sequence of a 1.26-kb DNA fragment containing the structural gene for E.coli initiation factor IF3: presence of an AUU initiator codon.
Sacerdot C, Fayat G, Dessen P, Springer M, Plumbridge JA, Grunberg-Manago M, Blanquet S.
(
6325158
)
|
Mol Gen Genet. 1982;186(2):247-52.
Transcription units around the gene for E. coli translation initiation factor IF3 (infC).
Springer M, Plumbridge JA, Trudel M, Graffe M, Grunberg-Manago M.
(
7050631
)
|
Gene. 1988;63(2):309-20.
Transcriptional patterns for the thrS-infC-rplT operon of Escherichia coli.
Wertheimer SJ, Klotsky RA, Schwartz I.
(
2838394
)
|
J Mol Biol. 1984;173(2):177-209.
Transcription of a gene cluster coding for two aminoacyl-tRNA synthetases and an initiation factor in Escherichia coli.
Wu TH, Wood DL, Stein PL, Comer MM.
(
6368838
)
|
Mol Gen Genet. 1987;208(1-2):94-100.
The unusual translational initiation codon AUU limits the expression of the infC (initiation factor IF3) gene of Escherichia coli.
Brombach M, Pon CL.
(
3302616
)
|
J Mol Biol. 1986;192(4):767-80.
Escherichia coli protein synthesis initiation factor IF3 controls its own gene expression at the translational level in vivo.
Butler JS, Springer M, Dondon J, Graffe M, Grunberg-Manago M.
(
2438418
)
|
Proc Natl Acad Sci U S A. 1987;84:4022-4025
AUU-to-AUG mutation in the initiator codon of the translation initiation factor IF3 abolishes translational autocontrol of its own gene (infC) in vivo.
Butler, J. S., M. Springer, and M. Grunberg-Manago.
|
Proc Natl Acad Sci U S A. 1997;94:9208-9213
Translational coupling by modulation of feedback repression in the IF3 operon of Escherichia coli.
Chiaruttini, C., M. Milet, and M. Springer.
|
Mol Gen Genet. 1985;198(2):299-303.
Intragenic suppression of the temperature-sensitivity caused by a mutation in a gene controlling transcription (fit) in Escherichia coli.
Dass SB, Jayaraman R.
(
2580214
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MKGGKRVQTA RPNRINGEIR AQEVRLTGLE GEQLGIVSLR EALEKAEEAG VDLVEISPNA EPPVCRIMDY
0071 GKFLYEKSKS SKEQKKKQKV IQVKEIKFRP GTDEGDYQVK LRSLIRFLEE GDKAKITLRF RGREMAHQQI
0141 GMEVLNRVKD DLQELAVVES FPTKIEGRQM IMVLAPKKKQ
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 ccgtggtaaa gacctgggaa gcatggacgt
-070 aaatgaagtg atcgagaagc tgcaacaaga gattcgcagc cgcagtctta aacaattgga ggaataaggt
0001 attaaaggcg gaaaacgagt tcaaacggcg cgccctaacc gtatcaatgg cgaaattcgc gcccaggaag
0071 ttcgcttaac aggtctggaa ggcgagcagc ttggtattgt gagtctgaga gaagctctgg agaaagcaga
0141 agaagccgga gtagacttag tcgagatcag ccctaacgcc gagccgccgg tttgtcgtat aatggattac
0211 ggcaaattcc tctatgaaaa gagcaagtct tctaaggaac agaagaaaaa gcaaaaagtt atccaggtta
0281 aggaaattaa attccgtcct ggtacagatg aaggcgacta tcaggtaaaa ctccgcagcc tgattcgctt
0351 tctcgaagag ggtgataaag ccaaaatcac gctgcgtttc cgcggtcgtg agatggcgca ccagcaaatc
0421 ggtatggaag tgcttaatcg cgtgaaagac gatttgcaag aactggcagt ggtcgaatcc ttcccaacga
0491 agatcgaagg ccgccagatg atcatggtgc tcgctcctaa gaagaaacag taaggccttc aagtagcact
0561 gtctgtggag ccttcgggct tcacaggctt tgttcgcctt tgtttcgttt attaacaatg cgaagtggaa
0631 gttattaaaa tgc
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