MG1655
W3110
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Gene Report : gyrB
PEC Original Annotations
Essentiality
     Class essential
     References (PMID)
Cell. 1984;36(4):1081-8.
Bacterial chromosome segregation: evidence for DNA gyrase involvement in decatenation.
Steck TR, Drlica K. ( 6323018 )
     Deletion OCL04 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  gyrB
Related strains
     Strains Search Search strains by gene name:  gyrB   Search strains by all related name:  gyrB acrB b3699 Cou ECK3691 f804 himB hisU hopA JW5625 nalC nalD parA pcbA pcpA

General information  (Go to Linear View:)
 Gene Name gyrB  
 Alternative name acrB,b3699,Cou,ECK3691,f804,himB,hisU,hopA,JW5625,nalC,nalD,parA,pcbA,pcpA  
 Location, Length 3,875,728 - 3,878,142 (  -  ) ;   83.53 min ; 2415 (bp) ,   804 (aa) Go to Linear View
 Product DNA gyrase, subunit B  
 Operon Name gyrB  
 Note DNA gyrase subunit B, type II topoisomerase, ATPase activity; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0006261 - DNA-dependent DNA replication; GO_process: GO:0006350 - transcription  
 Function enzyme; DNA - replication, repair,restriction/modification  
 Gene Ontology GO:0000166 ; nucleotide binding ( gyrB )
GO:0003676 ; nucleic acid binding ( gyrB )
GO:0003677 ; DNA binding ( gyrB )
GO:0003916 ; DNA topoisomerase activity ( gyrB )
GO:0003918 ; DNA topoisomerase (ATP-hydrolyzing) activity ( gyrB )
GO:0005215 ; transporter activity ( acrB )
GO:0005524 ; ATP binding ( gyrB )
GO:0005694 ; chromosome ( gyrB )
GO:0005886 ; plasma membrane ( acrB )
GO:0006265 ; DNA topological change ( gyrB )
GO:0006304 ; DNA modification ( gyrB )
GO:0006810 ; transport ( acrB )
GO:0016020 ; membrane ( acrB )
GO:0016021 ; integral to membrane ( acrB )
GO:0016853 ; isomerase activity ( gyrB )
GO:0046677 ; response to antibiotic ( gyrB )
 PID 48994957  
 EC number
  (KEGG Pathway)
 
5.99.1.3  
Verified Protein Starts (data compiled from literature and appropriate citations are available from EcoGene)
     EcoGene gyrB ( EG10424 )  
    Number of removed 1 aa cleaved  
SWISS-PROT  ( Show details [ 1 more] )
  botton Entry name(Acc.no) GYRB_ECOLI ( P06982 ; O08438 )
    -  Protein name DNA gyrase subunit B  
    -  Synonyms EC 5.99.1.3  
    -  Gene name OrderedLocusNames=b3699, z5190, ECs4634, SF3765, S4006;  

 Linear View (Whole Mode)
View Location
   3865.0  –  3890.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP acrB (  homologous genes of other bacterias  )   gyrB (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Dimerization Of E. Coli Dna Gyrase B Provides A Structural Mechanism For Activating The Atpase Catalytic Center  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST DNA gyrase subunit B  
         PSI-BLAST DNA gyrase subunit B
    nr     (database updated : 2007.02.20 )
         BLAST DNA gyrase subunit B [Escherichia coli O157:H7 str. Sakai]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    TYR_PHOSPHO_SITE    MYRISTYL    TOPOISOMERASE_II     

Other Cross-Reference
    COG COG0187L 
    EcoCyc gyrB 

MMBR References
Nucleic Acids Res. 1987;15:771-784
DNA sequence of the E. coli gyrB gene: application of a new sequencing strategy.
Adachi, T., M. Mizuuchi, A. Robinson, E. Appella, M. H. O'Dea, M. Gellert, and K. Mizuuchi.
Cell. 1982;31(1):43-51.
Escherichia coli DNA topoisomerase I mutants have compensatory mutations in DNA gyrase genes.
DiNardo S, Voelkel KA, Sternglanz R, Reynolds AE, Wright A. ( 6297752 )
Nucleic Acids Res. 1984;12:6389-6395
DNA sequence and transcription of the region upstream of the E. coli gyrB gene.
Adachi, T., R. Mizuuchi, R. Menzel, and M. Gellert.
Proc Natl Acad Sci U S A. 1976;73:4474-4478
Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.
Gellert, M., M. H. O'Dea, A. Itoh, and J.-I. Tomizawa.
J Biol Chem. 1996;271:24806-24810
Heat shock-induced DNA relaxation in vitro by DNA gyrase of Escherichia coli in the presence of ATP.
Kataoka, K., T. Mizushima, Y. Ogata, T. Miki, and K. Sekimizu.
J Bacteriol. 1987;169(3):1272-8.
Fusions of the Escherichia coli gyrA and gyrB control regions to the galactokinase gene are inducible by coumermycin treatment.
Menzel R, Gellert M. ( 3029031 )
Proc Natl Acad Sci U S A. 1987;84:4185-4189
Modulation of transcription by DNA supercoiling: a deletion analysis of the Escherichia coli gyrA and gyrB promoters.
Menzel, R., and M. Gellert.
Cold Spring Harbor Symp. Quant. Biol. 1978;43:1121-1126.
Site-specific recombination of bacteriophage lambda : the role of host gene products.
Miller, H. I., Y. Kikuchi, H. A. Nash, R. Weisberg, and D. I. Friedman.
Antimicrob Agents Chemother. 1989;33(2):254-5.
gyrA and gyrB mutations in quinolone-resistant strains of Escherichia coli.
Nakamura S, Nakamura M, Kojima T, Yoshida H. ( 2655532 )
Mol Gen Genet. 1979;177(1):103-12.
Isolation and characterisation of a strain carrying a conditional lethal mutation in the cou gene of Escherichia coli K12.
Orr E, Fairweather NF, Holland IB, Pritchard RH. ( 94144 )
J Bacteriol. 1992;174:5479-5481
Mutations causing aminotriazole resistance and temperature sensitivity reside in gyrB, which encodes the B subunit of DNA gyrase.
Toone, W. M., K. E. Rudd, and J. D. Friesen.
Res Microbiol. 1991;142(2-3):223-7.
DNA replication in Escherichia coli gyrB(Ts) mutants analysed by flow cytometry.
von Freiesleben U, Rasmussen KV. ( 1656495 )
ICN-UCLA Symp. Mol. Cell. Biol. 1980;19:137-159.
The origin of replication, oriC, of the Escherichia coli chromosome: genes near oriC and construction of oriC deletion mutations.
von Meyenburg, K., F. G. Hansen, E. Riise, H. E. N. Bergmans, M. Meijer, and W. Messer.
Mol Gen Genet. 1986;204(3):367-73.
Nalidixic acid-resistant mutations of the gyrB gene of Escherichia coli.
Yamagishi J, Yoshida H, Yamayoshi M, Nakamura S. ( 3020376 )
FEBS Lett. 1987;226(1):150-4.
A water-soluble form of penicillin-binding protein 2 of Escherichia coli constructed by site-directed mutagenesis.
Adachi H, Ohta T, Matsuzawa H. ( 2826251 )

Sequences
Amino acid
FASTA format
0001 MSNSYDSSSI KVLKGLDAVR KRPGMYIGDT DDGTGLHHMV FEVVDNAIDE ALAGHCKEII VTIHADNSVS 
0071 VQDDGRGIPT GIHPEEGVSA AEVIMTVLHA GGKFDDNSYK VSGGLHGVGV SVVNALSQKL ELVIQREGKI 
0141 HRQIYEHGVP QAPLAVTGET EKTGTMVRFW PSLETFTNVT EFEYEILAKR LRELSFLNSG VSIRLRDKRD 
0211 GKEDHFHYEG GIKAFVEYLN KNKTPIHPNI FYFSTEKDGI GVEVALQWND GFQENIYCFT NNIPQRDGGT 
0281 HLAGFRAAMT RTLNAYMDKE GYSKKAKVSA TGDDAREGLI AVVSVKVPDP KFSSQTKDKL VSSEVKSAVE 
0351 QQMNELLAEY LLENPTDAKI VVGKIIDAAR AREAARRARE MTRRKGALDL AGLPGKLADC QERDPALSEL 
0421 YLVEGDSAGG SAKQGRNRKN QAILPLKGKI LNVEKARFDK MLSSQEVATL ITALGCGIGR DEYNPDKLRY 
0491 HSIIIMTDAD VDGSHIRTLL LTFFYRQMPE IVERGHVYIA QPPLYKVKKG KQEQYIKDDE AMDQYQISIA 
0561 LDGATLHTNA SAPALAGEAL EKLVSEYNAT QKMINRMERR YPKAMLKELI YQPTLTEADL SDEQTVTRWV 
0631 NALVSELNDK EQHGSQWKFD VHTNAEQNLF EPIVRVRTHG VDTDYPLDHE FITGGEYRRI CTLGEKLRGL 
0701 LEEDAFIERG ERRQPVASFE QALDWLVKES RRGLSIQRYK GLGEMNPEQL WETTMDPESR RMLRVTVKDA 
0771 IAADQLFTTL MGDAVEPRRA FIEENALKAA NIDI

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             gaacacgtta tagacatgtc ggacgaaaat 
-070 tcgaagatgt ttaccgtgga aaagggtaaa ataacggatt aacccaagta taaatgagcg agaaacgttg 
0001 atgtcgaatt cttatgactc ctccagtatc aaagtcctga aagggctgga tgcggtgcgt aagcgcccgg 
0071 gtatgtatat cggcgacacg gatgacggca ccggtctgca ccacatggta ttcgaggtgg tagataacgc 
0141 tatcgacgaa gcgctcgcgg gtcactgtaa agaaattatc gtcaccattc acgccgataa ctctgtctct 
0211 gtacaggatg acgggcgcgg cattccgacc ggtattcacc cggaagaggg cgtatcggcg gcggaagtga 
0281 tcatgaccgt tctgcacgca ggcggtaaat ttgacgataa ctcctataaa gtgtccggcg gtctgcacgg 
0351 cgttggtgtt tcggtagtaa acgccctgtc gcaaaaactg gagctggtta tccagcgcga gggtaaaatt 
0421 caccgtcaga tctacgaaca cggtgtaccg caggccccgc tggcggttac cggcgagact gaaaaaaccg 
0491 gcaccatggt gcgtttctgg cccagcctcg aaaccttcac caatgtgacc gagttcgaat atgaaattct 
0561 ggcgaaacgt ctgcgtgagt tgtcgttcct caactccggc gtttccattc gtctgcgcga caagcgcgac 
0631 ggcaaagaag accacttcca ctatgaaggc ggcatcaagg cgttcgttga atatctgaac aagaacaaaa 
0701 cgccgatcca cccgaatatc ttctacttct ccactgaaaa agacggtatt ggcgtcgaag tggcgttgca 
0771 gtggaacgat ggcttccagg aaaacatcta ctgctttacc aacaacattc cgcagcgtga cggcggtact 
0841 cacctggcag gcttccgtgc ggcgatgacc cgtaccctga acgcctacat ggacaaagaa ggctacagca 
0911 aaaaagccaa agtcagcgcc accggtgacg atgcgcgtga aggcctgatt gcggtcgttt ccgtgaaagt 
0981 gccggacccg aaattctcct cccagaccaa agacaaactg gtttcttctg aggtgaaatc ggcggttgaa 
1051 cagcagatga acgaactgct ggcagaatac ctgctggaaa acccaaccga cgcgaaaatc gtggttggca 
1121 aaattatcga tgctgcccgt gcccgtgaag cggcgcgtcg cgcgcgtgaa atgacccgcc gtaaaggtgc 
1191 gctcgactta gcgggcctgc cgggcaaact ggcagactgc caggaacgcg atccggcgct ttccgaactg 
1261 tacctggtgg aaggggactc cgcgggcggc tctgcgaagc aggggcgtaa ccgcaagaac caggcgattc 
1331 tgccgctgaa gggtaaaatc ctcaacgtcg agaaagcgcg cttcgataag atgctctctt ctcaggaagt 
1401 ggcgacgctt atcaccgcgc ttggctgtgg tatcggtcgt gacgagtaca acccggacaa actgcgttat 
1471 cacagcatca tcatcatgac cgatgcggac gtcgacggct cgcacattcg tacgctgctg ttgaccttct 
1541 tctatcgtca gatgccggaa atcgttgaac gcggtcacgt ctacatcgct cagccgccgc tgtacaaagt 
1611 gaagaaaggc aagcaggaac agtacattaa agacgacgaa gcgatggatc agtaccagat ctctatcgcg 
1681 ctggacggcg caacgctgca caccaacgcc agtgcaccgg cattggctgg cgaagcgtta gagaaactgg 
1751 tatctgagta caacgcgacg cagaaaatga tcaatcgtat ggagcgtcgt tatccgaaag caatgctgaa 
1821 agagcttatc tatcagccga cgttgacgga agctgacctt tctgatgagc agaccgttac ccgctgggtg 
1891 aacgcgctgg tcagcgaact gaacgacaaa gaacagcacg gcagccagtg gaagtttgat gttcacacca 
1961 atgctgagca aaacctgttc gagccgattg ttcgcgtgcg tacccacggt gtggatactg actatccgct 
2031 ggatcacgag tttatcaccg gtggcgaata tcgtcgtatc tgcacgctgg gtgagaaact gcgtggcttg 
2101 ctggaagaag atgcgtttat cgaacgtggc gagcgtcgtc agccggtagc cagcttcgag caggcgctgg 
2171 actggctggt gaaagagtcc cgtcgcggcc tctccatcca gcgttataaa ggtctgggcg agatgaaccc 
2241 ggaacagctg tgggaaacca ctatggaccc ggaaagtcgt cgtatgctgc gcgttaccgt taaagatgcg 
2311 attgctgccg accagttgtt caccacgctg atgggcgacg ccgttgaacc gcgccgtgcg tttattgaag 
2381 agaacgccct gaaagcggcg aatatcgata tttaatggcg ctaaccatgc gagcgtgcct gatgcgctac 
2451 gcttatcagg cctacgaaaa tcttgcaatg tattgaattt tcatgatttt gtaggccgga taagg