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PEC Original Annotations
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|
Essentiality
|
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Class
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non-essential
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|
References (PMID)
|
|
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Deletion
|
16-1-2
(LD)
,
DE(sbcB-rfb)202
,
DE(hisG-hisI)870
,
OCL74-2,75-5 (LD 16-1-2_CRS)
(D)
,
OCL74-2,75-6 (LD 16-1-2_P/O)
(D)
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Related gene (W3110 PEC)
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Gene Search
|
Search MG1655 PEC by gene name:
hisD
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Related strains
|
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Strains Search
|
Search strains by gene name:
hisD
Search strains by all related name:
hisD b2020 ECK2015 JW2002
|
General information (Go to Linear View: )
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Gene Name
|
hisD
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Alternative name
|
b2020,ECK2015,JW2002
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Location, Length
|
2,089,121 - 2,090,425
(
+
)
;
45.03
min
;
1305
(bp) ,
434
(aa)
|
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Product
|
bifunctional histidinal dehydrogenase/ histidinol dehydrogenase
|
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Operon Name
|
hisLGDCBHAFI
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Note
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L-histidinal:NAD+ oxidoreductase; L-histidinol:NAD+ oxidoreductase; GO_process: GO:0000105 - histidine biosynthetic process
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Function
|
enzyme; Amino acid biosynthesis: Histidine
|
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Gene Ontology
|
GO:0000105
;
histidine biosynthetic process ( hisD )
GO:0004399
;
histidinol dehydrogenase activity ( hisD )
GO:0008152
;
metabolic process ( hisD )
GO:0008270
;
zinc ion binding ( hisD )
GO:0008652
;
amino acid biosynthetic process ( hisD )
GO:0016491
;
oxidoreductase activity ( hisD )
GO:0046872
;
metal ion binding ( hisD )
GO:0051287
;
NAD binding ( hisD )
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PID
|
1788331
|
EC number
(KEGG Pathway)
|
1.1.1.23
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Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
hisD
(
EG10447
)
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Number of removed
|
1 aa cleaved
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SWISS-PROT
(
Show details
[
2
more]
)
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Entry name(Acc.no)
|
HISX_ECOLI
(
P06988
;
O08506; P78076; Q47254
)
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- Protein name
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Histidinol dehydrogenase
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- Synonyms
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EC 1.1.1.23, HDH
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- Gene name
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Name=hisD; OrderedLocusNames=b2020;
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MMBR References
|
J Bacteriol. 1980;142(1):32-42.
Structural and physiological studies of the Escherichia coli histidine operon inserted into plasmid vectors.
Bruni CB, Musti AM, Frunzio R, Blasi F.
(
6246067
)
|
J Bacteriol. 1992;174(11):3830-1.
Location of the hisGDCBHAFI operon on the physical map of Escherichia coli.
Alifano P, Carlomagno MS, Bruni CB.
(
1592835
)
|
Mol Gen Genet. 1986;203(3):382-8.
Nucleotide sequence of the Escherichia coli hisD gene and of the Escherichia coli and Salmonella typhimurium hisIE region.
Chiariotti L, Alifano P, Carlomagno MS, Bruni CB.
(
3018428
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MSFNTIIDWN SCTAEQQRQL LMRPAISASE SITRTVNDIL DNVKARGDEA LREYSAKFDK TTVTALKVSA
0071 EEIAAASERL SDELKQAMAV AVKNIETFHT AQKLPPVDVE TQPGVRCQQV TRPVASVGLY IPGGSAPLFS
0141 TVLMLATPAS IAGCKKVVLC SPPPIADEIL YAAQLCGVQD VFNVGGAQAI AALAFGTESV PKVDKIFGPG
0211 NAFVTEAKRQ VSQRLDGAAI DMPAGPSEVL VIADSGATPD FVASDLLSQA EHGPDSQVIL LTPAADMARR
0281 VAEAVERQLA ELPRAETARQ ALNASRLIVT KDLAQCVEIS NQYGPEHLII QTRNARELVD SITSAGSVFL
0351 GDWSPESAGD YASGTNHVLP TYGYTATCSS LGLADFQKRM TVQELSKEGF SALASTIETL AAAERLTAHK
0421 NAVTLRVNAL KEQA
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 GCAGCGAAAC CCTGTTCTGG GAAACCATGG
-070 AAAAACTGAA AGCGCTGGGT GCCAGTTCAA TTCTGGTCCT GCCGATTGAG AAGATGATGG AGTGATCGCC
0001 atgagcttta acacaatcat tgactggaat agctgtactg cggagcaaca acgccagctg ttaatgcgcc
0071 cggcgatttc cgcctctgaa agcattaccc gcactgttaa cgatattctc gataacgtga aagcacgcgg
0141 cgatgaggcc ctgcgggaat acagcgcgaa gtttgataaa accacggtta ccgcgctgaa ggtgtctgca
0211 gaggagatcg ccgccgccag cgaacgcctg agcgacgagc taaaacaggc gatggcggtg gcagtaaaga
0281 atattgaaac cttccacact gcgcaaaaac tgccgccggt agatgtagaa acgcagccag gcgtgcgttg
0351 ccagcaggtc acgcgtccgg tagcttcagt tgggttgtat attcctggcg gctccgcccc gctcttctca
0421 acggtattaa tgctggcgac tccggcgagt attgcgggct gtaaaaaagt ggtgctgtgc tcaccgccgc
0491 cgattgccga tgagatcctt tatgcggcgc agctgtgcgg tgtgcaggac gtgtttaacg tcggcggcgc
0561 acaggccatt gccgcactgg cgtttggtac ggaatctgtg ccaaaagtgg acaaaatctt cgggccgggt
0631 aacgcctttg tcaccgaagc gaaacgtcag gtgagccagc gtctggacgg tgcggcgatc gatatgcccg
0701 caggcccgtc ggaagtgctg gtgattgctg acagcggcgc tacgccggat ttcgtggctt ctgatttgct
0771 ctctcaggct gaacacggcc cggactcaca ggtgatttta ctgacgcccg ctgctgatat ggcgcgtcgc
0841 gttgccgagg ccgtcgaacg ccaactggca gaactgccgc gtgccgaaac cgcccgccag gcactgaacg
0911 ccagccgcct gatcgtgact aaagatttag cgcagtgcgt ggagatctcc aaccagtacg gcccggagca
0981 cctgatcatt cagacccgca acgcccgtga actggtcgat agcatcacca gcgccggttc ggtatttctt
1051 ggtgactggt caccggaatc ggcaggtgat tacgcctccg gcaccaacca cgttctaccg acttacggtt
1121 acaccgccac ctgttccagc ctcgggctgg cagatttcca gaagcgcatg accgtacagg aactgtcgaa
1191 agaggggttc tccgcgctgg cttcaaccat agaaacactg gccgccgccg agcgcctgac cgcccacaaa
1261 aatgccgtta ctttgcgtgt taacgccctt aaggagcaag catgaGCACC GTGACTATTA CCGATTTAGC
1331 GCGTGAAAAC GTCCGCAACC TGACGCCGTA TCAGTCGGCG CGTCGTCTGG GCGGTAACGG CGATGTCTGG
1401 CTGAA
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