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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Cell. 1983;32(3):783-8.
A control element within a structural gene: the gal operon of Escherichia coli.
Irani MH, Orosz L, Adhya S.
(
6299576
)
|
|
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Deletion
|
OCL44
(D)
|
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Related gene (W3110 PEC)
|
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Gene Search
|
Search MG1655 PEC by gene name:
galR
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Related strains
|
|
Strains Search
|
Search strains by gene name:
galR
Search strains by all related name:
galR b2837 ECK2835 JW2805
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General information (Go to Linear View: )
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Gene Name
|
galR
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Alternative name
|
b2837,ECK2835,JW2805
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Location, Length
|
2,974,621 - 2,975,652
(
+
)
;
64.11
min
;
1032
(bp) ,
343
(aa)
|
|
Product
|
DNA-binding transcriptional repressor
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Operon Name
|
galR
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Note
|
repressor of galETK operon; GO_component: GO:0005737 - cytoplasm; GO_function: GO:0016564 - transcription repressor activity; GO_process: GO:0016052 - carbohydrate catabolic process; GO_process: GO:0006350 - transcription
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Function
|
regulator; Degradation of small molecules: Carbon compounds
|
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Gene Ontology
|
GO:0003677
;
DNA binding ( galR )
GO:0003700
;
transcription factor activity ( galR )
GO:0005515
;
protein binding ( galR )
GO:0005622
;
intracellular ( galR )
GO:0005975
;
carbohydrate metabolic process ( galR )
GO:0006012
;
galactose metabolic process ( galR )
GO:0006350
;
transcription ( galR )
GO:0006355
;
regulation of transcription, DNA-dependent ( galR )
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PID
|
1789202
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EC number
(KEGG Pathway)
|
|
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SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
GALR_ECOLI
(
P03024
)
|
|
- Protein name
|
HTH-type transcriptional regulator galR
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- Synonyms
|
Galactose operon repressor
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- Gene name
|
Name=galR; OrderedLocusNames=b2837;
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Homology Analysis
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BLAST
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Bacteria
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GTOP
|
galR
(
homologous genes of other bacterias
)
|
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PDB
(database updated :
2007.02.20
)
|
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PSI-BLAST
|
Chain A, Crystal Structure Of A Ccpa-Crh-Dna Complex
|
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SWISS-PROT
(database updated :
2007.02.20
)
|
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BLAST
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HTH-type transcriptional regulator galR
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PSI-BLAST
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Ribose operon repressor
|
|
nr
(database updated :
2007.02.20
)
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BLAST
|
DNA-binding transcriptional repressor [Escherichia coli K12]
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Pfam 28.0
(database updated :
2015-05
)
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Pfam
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PROSITE
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PROSITE
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ASN_GLYCOSYLATION
CAMP_PHOSPHO_SITE
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
TYR_PHOSPHO_SITE
MYRISTYL
HTH_LACI_FAMILY
|
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MMBR References
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J Bacteriol. 1997;179:228-234
Functional characterization of roles of GalR and GalS as regulators of the gal regulon.
Geanacopoulos, M., and S. Adhya.
|
Mol Gen Genet. 1980;179(1):49-54.
Characterisation of mutants of Escherichia coli K12, selected by resistance to streptozotocin.
Lengeler J.
(
6450313
)
|
Biochem J. 1981;196(1):269-83.
Identification of the AraE transport protein of Escherichia coli.
MacPherson AJ, Jones-Mortimer MC, Henderson PJ.
(
7030324
)
|
Mol Gen Genet. 1968;102(1):79-88.
Negative control of the galactose operon in E. coli.
Saedler H, Gullon A, Fiethen L, Starlinger P.
(
4883532
)
|
Proc Natl Acad Sci U S A. 1982;79:2427-2431
Sequence of galR gene indicates a common evolutionary origin of lac and gal repressor in Escherichia coli.
von Wilcken-Bergmann, B., and B. Muller-Hill.
|
J Biol Chem. 1992;267:15869-15874
A family of bacterial regulators homologous to Gal and Lac repressors.
Weichert, M. J., and S. Adhya.
|
J Bacteriol. 1993;175:251-258
Control of transcription of Gal repressor and isorepressor genes in Escherichia coli.
Weichert, M. J., and S. Adhya.
|
Mol Microbiol. 1993;10(2):245-51.
The galactose regulon of Escherichia coli.
Weickert MJ, Adhya S.
(
7934815
)
|
J Mol Biol. 1995;253(3):414-25.
The non-inducible nature of super-repressors of the gal operon in Escherichia coli.
Zhou YN, Chatterjee S, Roy S, Adhya S.
(
7473724
)
|
J Mol Biol. 1963;7:183-205.
Mecanismes regulateurs dans la biosynthese des enzymes du metabolisme du galactose chez Escherichia coli K12. II. Le determinisme genetique de la regulation.
Buttin, G.
|
| Sequences |
Amino acid
FASTA format
|
0001 MATIKDVARL AGVSVATVSR VINNSPKASE ASRLAVHSAM ESLSYHPNAN ARALAQQTTE TVGLVVGDVS
0071 DPFFGAMVKA VEQVAYHTGN FLLIGNGYHN EQKERQAIEQ LIRHRCAALV VHAKMIPDAD LASLMKQMPG
0141 MVLINRILPG FENRCIALDD RYGAWLATRH LIQQGHTRIG YLCSNHSISD AEDRLQGYYD ALAESGIAAN
0211 DRLVTFGEPD ESGGEQAMTE LLGRGRNFTA VACYNDSMAA GAMGVLNDNG IDVPGEISLI GFDDVLVSRY
0281 VRPRLTTVRY PIVTMATQAA ELALALADNR PLPEITNVFS PTLVRRHSVS TPSLEASHHA TSD
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 TGGCTCACAT TCCCACGATG AAAACACGCC
-070 ACCCCTTGAA CCAACGGGCG TTTTCCGTAA CACTGAAAGA ATGTAAGCGT TTACCCACTA AGGTATTTTC
0001 atggcgacca taaaggatgt agcccgactg gcaggcgttt cagtcgccac cgtttcccgc gtcattaata
0071 attcacccaa agccagcgaa gcttcccggc tggctgtgca tagtgcaatg gagtctctta gctatcaccc
0141 gaacgccaac gcccgtgcgc tggcgcagca gaccactgaa acggtcggtc tggtcgttgg tgatgtttcc
0211 gatccgtttt tcggtgcaat ggtgaaagcg gtcgaacagg tggcttatca caccggtaat tttttattga
0281 ttggcaacgg ttaccacaac gaacaaaaag agcgtcaggc cattgagcaa ctgatccgcc atcgctgtgc
0351 tgcgttggtc gtccatgcca aaatgatccc ggatgctgat ttagcctcat taatgaaaca aatgcccggt
0421 atggtgctga tcaaccgtat cctgcctggc tttgaaaacc gttgtattgc tctggacgat cgttacggtg
0491 cctggctggc aacgcgtcat ttaattcagc aaggtcatac ccgcattggt tatctgtgct ctaaccactc
0561 tatttctgac gccgaagatc gtctgcaagg gtattacgat gcccttgctg aaagtggtat tgcggccaat
0631 gaccggctgg tgacatttgg cgaaccagac gaaagcggcg gcgaacaggc aatgaccgag cttttgggac
0701 gaggaagaaa tttcactgcg gtagcctgtt ataacgattc aatggcggcg ggtgcgatgg gcgttctcaa
0771 tgataatggt attgatgtac cgggtgagat ttcgttaatt ggctttgatg atgtgctggt gtcacgctat
0841 gtgcgtccgc gcctgaccac cgtgcgttac ccaatcgtga cgatggcgac ccaggctgcc gaactggctt
0911 tggcgctggc ggataatcgc cctctcccgg aaatcactaa tgtctttagt ccgacgctgg tacgtcgtca
0981 ttcagtgtca actccgtcgc tggaggcaag tcatcatgca accagcgact aaCCGCAGTT AAAGCAATTC
1051 CAGCGCCAGT AATTCTTCGA TGGTCTGGCG ACGGCGAATC AACCGCGCCT GACCATTATC AAACAGAACT
1121 TCTGGTAACA GC
|
